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Susanne Wells, PhD

Associate Professor, Department of Pediatrics, UC College of Medicine; Director, Epithelial Carcinogenesis and Stem Cell Program; Cancer Biology

Contact Information
  • Cincinnati Children's Hospital Medical Center
  • 3333 Burnet Avenue
  • Cincinnati, Ohio
  • Office 513-636-5986
  • Email Susanne.Wells@cchmc.org
  • UC Institute Member Seal

Peer Reviewed Publications

Nowrouzi, Ali; Sertorio, Mathieu G; Akbarpour, Mahdi; Knoll, Maximillian; Krunic, Damir; Kuhar, Matthew; Schwager, Christian; Brons, Stephan; Debus, Jürgen; Wells, Susanne I; Wells, James M; Abdollahi, Amir 2020. Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids. Cancers, 12 2,

van Harten, Anne M; Poell, Jos B; Buijze, Marijke; Brink, Arjen; Wells, Susanne I; René Leemans, C; Wolthuis, Rob M F; Brakenhoff, Ruud H 2019. Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass. Oral oncology, 98 , 53-61

Khoury, Ruby; Sauter, Sharon; Butsch Kovacic, Melinda; Nelson, Adam S; Myers, Kasiani C; Mehta, Parinda A; Davies, Stella M; Wells, Susanne I 2018. Risk of Human Papillomavirus Infection in Cancer-Prone Individuals: What We Know. Viruses, 10 1,

Matrka, Marie C; Cimperman, Katherine A; Haas, Sarah R; Guasch, Geraldine; Ehrman, Lisa A; Waclaw, Ronald R; Komurov, Kakajan; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2018. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. PLoS genetics, 14 3, e1007227

Nicol, Alcina F; de Andrade, Cecilia Vianna; Gomes, Saint Clair; Brusadelli, Marion G; Lodin, Hannah M; Wells, Susanne I; Nuovo, Gerard J 2018. The distribution of novel biomarkers in carcinoma-in-situ, microinvasive, and squamous cell carcinoma of the uterine cervix. Annals of diagnostic pathology, 38 , 115-122

Nuovo, Gerard J; de Andrade, Cecilia Vianna; Wells, Susanne I; Brusadelli, Marion; Nicol, Alcina F 2018. New biomarkers of human papillomavirus infection in acute cervical intraepithelial neoplasia. Annals of diagnostic pathology, 36 , 21-27

Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M 2018. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors. Experimental hematology, 59 , 40-50.e3

Sertorio, Mathieu; Perentesis, John P; Vatner, Ralph E; Mascia, Anthony E; Zheng, Yi; Wells, Susanne I 2018. Cancer Cell Metabolism: Implications for X-ray and Particle Radiation Therapy. International journal of particle therapy, 5 1, 40-48

Smith, Eric A; Krumpelbeck, Eric F; Jegga, Anil G; Prell, Malte; Matrka, Marie M; Kappes, Ferdinand; Greis, Kenneth D; Ali, Abdullah M; Meetei, Amom R; Wells, Susanne I 2018. The nuclear DEK interactome supports multi-functionality. Proteins, 86 1, 88-97

Toptan, Tuna; Brusadelli, Marion G; Turpin, Brian; Witte, David P; Surrallés, Jordi; Velleuer, Eunike; Schramm, Martin; Dietrich, Ralf; Brakenhoff, Ruud H; Moore, Patrick S; Chang, Yuan; Wells, Susanne I 2018. Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma. PloS one, 13 12, e0209235

Trisno, Stephen L; Philo, Katherine E D; McCracken, Kyle W; Catá, Emily M; Ruiz-Torres, Sonya; Rankin, Scott A; Han, Lu; Nasr, Talia; Chaturvedi, Praneet; Rothenberg, Marc E; Mandegar, Mohammad A; Wells, Susanne I; Zorn, Aaron M; Wells, James M 2018. Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification. Cell stem cell, 23 4, 501-515.e7

Zhao, Xueheng; Brusadelli, Marion G; Sauter, Sharon L; Butsch Kovacic, Melinda; Zhang, Wujuan; Romick-Rosendale, Lindsey E; Lambert, Paul F; Setchell, Kenneth D; Wells, Susanne I 2018. Lipidomic profiling links the Fanconi anemia pathway to glycosphingolipid metabolism in head and neck cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research, ,

Koncar, Robert F; Chu, Zhengtao; Romick-Rosendale, Lindsey E; Wells, Susanne I; Chan, Timothy A; Qi, Xiaoyang; Bahassi, El Mustapha 2017. PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas. Oncotarget, 8 9, 15827-15837

Matrka, Marie C; Watanabe, Miki; Muraleedharan, Ranjithmenon; Lambert, Paul F; Lane, Andrew N; Romick-Rosendale, Lindsey E; Wells, Susanne I 2017. Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis. PloS one, 12 5, e0177952

Mehta, Parinda A; Sauter, Sharon; Zhang, Xue; Davies, Stella M; Wells, Suzanne I; Myers, Kasiani C; Panicker, Gitika; Unger, Elizabeth R; Butsch Kovacic, Melinda 2017. Antibody response to human papillomavirus vaccination and natural exposure in individuals with Fanconi Anemia. Vaccine, 35 48 Pt B, 6712-6719

Myers, Kasiani C; Sauter, Sharon; Zhang, Xue; Bleesing, Jacob J; Davies, Stella M; Wells, Susanne I; Mehta, Parinda A; Kumar, Ashish; Marmer, Daniel; Marsh, Rebecca; Brown, Darron; Butsch Kovacic, Melinda 2017. Impaired immune function in children and adults with Fanconi anemia. Pediatric blood & cancer, 64 11,

Smith, Eric A; Gole, Boris; Willis, Nicholas A; Soria, Rebeca; Starnes, Linda M; Krumpelbeck, Eric F; Jegga, Anil G; Ali, Abdullah M; Guo, Haihong; Meetei, Amom R; Andreassen, Paul R; Kappes, Ferdinand; Vinnedge, Lisa M Privette; Daniel, Jeremy A; Scully, Ralph; Wiesmüller, Lisa; Wells, Susanne I 2017. DEK is required for homologous recombination repair of DNA breaks. Scientific reports, 7 , 44662

Smith, Eric A; Kumar, Bhavna; Komurov, Kakajan; Smith, Stephen M; Brown, Nicole V; Zhao, Songzhu; Kumar, Pawan; Teknos, Theodoros N; Wells, Susanne I 2017. DEK associates with tumor stage and outcome in HPV16 positive oropharyngeal squamous cell carcinoma. Oncotarget, 8 14, 23414-23426

Chlon, Timothy M; Ruiz-Torres, Sonya; Maag, Logan; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2016. Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Stem cell reports, 6 1, 44-54

Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I 2016. Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. Clinical cancer research : an official journal of the American Association for Cancer Research, 22 8, 2062-73

Tuttle, Traci R; Mierzwa, Michelle L; Wells, Susanne I; Fox, Sejal R; Ben-Jonathan, Nira 2016. The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma. Cancer letters, 370 2, 279-85

Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I 2015. DEK promotes HPV-positive and -negative head and neck cancer cell proliferation. Oncogene, 34 7, 868-77

Adams, Allie K; Bolanos, Lyndsey C; Dexheimer, Phillip J; Karns, Rebekah A; Aronow, Bruce J; Komurov, Kakajan; Jegga, Anil G; Casper, Keith A; Patil, Yash J; Wilson, Keith M; Starczynowski, Daniel T; Wells, Susanne I 2015. IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. Oncotarget, 6 41, 43395-407

Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D; Wikenheiser-Brokamp, Kathryn A; Wiesmueller, Lisa; Hanenberg, Helmut; Andreassen, Paul; Jacobs, Allison J; Olson, Susan B; Keeble, Winifred W; Hays, Laura; Wells, Susanne I 2015. Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 8, 1962-72

Matrka, Marie C; Hennigan, Robert F; Kappes, Ferdinand; DeLay, Monica L; Lambert, Paul F; Aronow, Bruce J; Wells, Susanne I 2015. DEK over-expression promotes mitotic defects and micronucleus formation. Cell cycle (Georgetown, Tex.), 14 24, 3939-53

Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I 2015. The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene, 34 18, 2325-36

Sauter, Sharon L; Wells, Susanne I; Zhang, Xue; Hoskins, Elizabeth E; Davies, Stella M; Myers, Kasiani C; Mueller, Robin; Panicker, Gitika; Unger, Elizabeth R; Sivaprasad, Umasundari; Brown, Darron R; Mehta, Parinda A; Butsch Kovacic, Melinda 2015. Oral human papillomavirus is common in individuals with Fanconi anemia. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 24 5, 864-72

Adams, Allie K; Wise-Draper, Trisha M; Wells, Susanne I 2014. Human papillomavirus induced transformation in cervical and head and neck cancers. Cancers, 6 3, 1793-820

Chlon, Timothy M; Hoskins, Elizabeth E; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2014. High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells. Journal of virology, 88 19, 11315-26

Bahassi, El Mustapha; Li, Ya-Qin; Wise-Draper, Trisha M; Deng, Li; Wang, Jiang; Darnell, Colleen N; Wilson, Keith M; Wells, Susanne I; Stambrook, Peter J; Rixe, Olivier 2013. A patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck cancer. European journal of cancer (Oxford, England : 1990), 49 10, 2345-55

Kim, Kui-Jin; Godarova, Alzbeta; Seedle, Kari; Kim, Min-Ho; Ince, Tan A; Wells, Susanne I; Driscoll, James J; Godar, Samuel 2013. Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner. PloS one, 8 12, e80590

Privette Vinnedge, Lisa M; Kappes, Ferdinand; Nassar, Nicolas; Wells, Susanne I 2013. Stacking the DEK: from chromatin topology to cancer stem cells. Cell cycle (Georgetown, Tex.), 12 1, 51-66

Yablonska, Svitlana; Hoskins, Elizabeth E; Wells, Susanne I; Khan, Saleem A 2013. Identification of miRNAs dysregulated in human foreskin keratinocytes (HFKs) expressing the human papillomavirus (HPV) Type 16 E6 and E7 oncoproteins. MicroRNA (Shariqah, United Arab Emirates), 2 1, 2-13

Hoskins, Elizabeth E; Morreale, Richard J; Werner, Stephen P; Higginbotham, Jennifer M; Laimins, Laimonis A; Lambert, Paul F; Brown, Darron R; Gillison, Maura L; Nuovo, Gerard J; Witte, David P; Kim, Mi-Ok; Davies, Stella M; Mehta, Parinda A; Butsch Kovacic, Melinda; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The fanconi anemia pathway limits human papillomavirus replication. Journal of virology, 86 15, 8131-8

Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PloS one, 7 10, e46985

Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. Future directions and treatment strategies for head and neck squamous cell carcinomas. Translational research : the journal of laboratory and clinical medicine, 160 3, 167-77

Kavanaugh, Gina M; Wise-Draper, Trisha M; Morreale, Richard J; Morrison, Monique A; Gole, Boris; Schwemberger, Sandy; Tichy, Elisia D; Lu, Lu; Babcock, George F; Wells, James M; Drissi, Rachid; Bissler, John J; Stambrook, Peter J; Andreassen, Paul R; Wiesmüller, Lisa; Wells, Susanne I 2011. The human DEK oncogene regulates DNA damage response signaling and repair. Nucleic acids research, 39 17, 7465-76

Morrison, Monique A; Morreale, Richard J; Akunuru, Shailaja; Kofron, Matthew; Zheng, Yi; Wells, Susanne I 2011. Targeting the human papillomavirus E6 and E7 oncogenes through expression of the bovine papillomavirus type 1 E2 protein stimulates cellular motility. Journal of virology, 85 20, 10487-98

Myers, Kasiani C; Bleesing, Jack J; Davies, Stella M; Zhang, Xue; Martin, Lisa J; Mueller, Robin; Harris, Richard E; Filipovich, Alexandra H; Kovacic, Melinda B; Wells, Susanne I; Mehta, Parinda A 2011. Impaired immune function in children with Fanconi anaemia. British journal of haematology, 154 2, 234-40

Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I 2011. The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene, 30 24, 2741-52

Spence, Jason R; Mayhew, Christopher N; Rankin, Scott A; Kuhar, Matthew F; Vallance, Jefferson E; Tolle, Kathryn; Hoskins, Elizabeth E; Kalinichenko, Vladimir V; Wells, Susanne I; Zorn, Aaron M; Shroyer, Noah F; Wells, James M 2011. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature, 470 7332, 105-9

Wald, Abigail I; Hoskins, Elizabeth E; Wells, Susanne I; Ferris, Robert L; Khan, Saleem A 2011. Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus. Head & neck, 33 4, 504-12

Blanchard, Carine; Stucke, Emily M; Burwinkel, Karen; Caldwell, Julie M; Collins, Margaret H; Ahrens, Annette; Buckmeier, Bridget K; Jameson, Sean C; Greenberg, Allison; Kaul, Ajay; Franciosi, James P; Kushner, Jonathan P; Martin, Lisa J; Putnam, Philip E; Abonia, J Pablo; Wells, Suzanne I; Rothenberg, Marc E 2010. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. Journal of immunology (Baltimore, Md. : 1950), 184 7, 4033-41

Meyer, Sara E; Peace, Belinda E; Bahassi, El Mustapha; Kavanaugh, Gina M; Wagh, Purnima K; Robbins, Susan B; Yin, Moying; Wells, Susanne I; Zinser, Glendon M; Stambrook, Peter J; Waltz, Susan E 2010. Chk2*1100delC Acts in synergy with the Ron receptor tyrosine kinase to accelerate mammary tumorigenesis in mice. Cancer letters, 296 2, 186-93

Bourgo, Ryan J; Braden, Wesley A; Wells, Susanne I; Knudsen, Erik S 2009. Activation of the retinoblastoma tumor suppressor mediates cell cycle inhibition and cell death in specific cervical cancer cell lines. Molecular carcinogenesis, 48 1, 45-55

Hoskins, E E; Morris, T A; Higginbotham, J M; Spardy, N; Cha, E; Kelly, P; Williams, D A; Wikenheiser-Brokamp, K A; Duensing, S; Wells, S I 2009. Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture. Oncogene, 28 5, 674-85

Spardy, Nicole; Covella, Kathryn; Cha, Elliot; Hoskins, Elizabeth E; Wells, Susanne I; Duensing, Anette; Duensing, Stefan 2009. Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin. Cancer research, 69 17, 7022-9

Wise-Draper, Trisha M; Mintz-Cole, Rachael A; Morris, Teresa A; Simpson, David S; Wikenheiser-Brokamp, Kathryn A; Currier, Mark A; Cripe, Timothy P; Grosveld, Gerard C; Wells, Susanne I 2009. Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo. Cancer research, 69 5, 1792-9

Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I 2009. DEK proto-oncogene expression interferes with the normal epithelial differentiation program. The American journal of pathology, 174 1, 71-81

Hoskins, E E; Gunawardena, R W; Habash, K B; Wise-Draper, T M; Jansen, M; Knudsen, E S; Wells, S I 2008. Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway. Oncogene, 27 35, 4798-808

Spardy, Nicole; Duensing, Anette; Hoskins, Elizabeth E; Wells, Susanne I; Duensing, Stefan 2008. HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies. Cancer research, 68 23, 9954-63

Wise-Draper, Trisha M; Wells, Susanne I 2008. Papillomavirus E6 and E7 proteins and their cellular targets. Frontiers in bioscience : a journal and virtual library, 13 , 1003-17

Blanchard, Carine; Mingler, Melissa K; Vicario, Maria; Abonia, J Pablo; Wu, Yi Ying; Lu, Thomas X; Collins, Margaret H; Putnam, Philip E; Wells, Susanne I; Rothenberg, Marc E 2007. IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. The Journal of allergy and clinical immunology, 120 6, 1292-300

Jones, Elizabeth E; Wells, Susanne I 2006. Cervical cancer and human papillomaviruses: inactivation of retinoblastoma and other tumor suppressor pathways. Current molecular medicine, 6 7, 795-808

Wise-Draper, Trisha M; Allen, Hillary V; Jones, Elizabeth E; Habash, Kristen B; Matsuo, Hiroshi; Wells, Susanne I 2006. Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions. Molecular and cellular biology, 26 20, 7506-19

Wise-Draper, Trisha M; Allen, Hillary V; Thobe, Megan N; Jones, Elizabeth E; Habash, Kristen B; Münger, Karl; Wells, Susanne I 2005. The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7. Journal of virology, 79 22, 14309-17

Erturk, Ece; Ostapchuk, Philomena; Wells, Susanne I; Yang, Jihong; Gregg, Keqin; Nepveu, Alain; Dudley, Jaquelin P; Hearing, Patrick 2003. Binding of CCAAT displacement protein CDP to adenovirus packaging sequences. Journal of virology, 77 11, 6255-64

Wells, Susanne I; Aronow, Bruce J; Wise, Trisha M; Williams, Sarah S; Couget, Jennifer A; Howley, Peter M 2003. Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells. Proceedings of the National Academy of Sciences of the United States of America, 100 12, 7093-8

Romick-Rosendale, Lindsey E; Lui, Vivian W Y; Grandis, Jennifer R; Wells, Susanne I . The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. Mutation research, 743-744 , 78-88