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Alvaro Puga

Research Interests

My laboratory investigates the impact of genetic diversity on the response of individuals or populations to toxic or carcinogenic environmental agents. The long-term objective of this work is to elucidate the molecular mechanisms that underlie this respon...

Education/Credentials
  • Ph.D.: Purdue University
Contact Information

Peer Reviewed Publications

Khanal, Tilak; Choi, Kwangmin; Leung, Yuet-Kin; Wang, Jiang; Kim, Dasom; Janakiram, Vinothini; Cho, Sung-Gook; Puga, Alvaro; Ho, Shuk-Mei; Kim, Kyounghyun 2017. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Scientific reports, 7 1, 10662

Ko, Chia-I; Puga, Alvaro 2017. Does the Aryl Hydrocarbon Receptor Regulate Pluripotency? Current opinion in toxicology, 2 , 1-7

Wang, Qin; Fan, Yunxia; Kurita, Hisaka; Jiang, Min; Koch, Sheryl; Rao, Marepalli B; Rubinstein, Jack; Puga, Alvaro 2017. Aryl Hydrocarbon Receptor Ablation in Cardiomyocytes Protects Male Mice from Heart Dysfunction Induced by NKX2.5 Haploinsufficiency. Toxicological sciences : an official journal of the Society of Toxicology, ,

Ko, Chia-I; Fan, Yunxia; de Gannes, Matthew; Wang, Qin; Xia, Ying; Puga, Alvaro 2016. Repression of the Aryl Hydrocarbon Receptor Is Required to Maintain Mitotic Progression and Prevent Loss of Pluripotency of Embryonic Stem Cells. Stem cells (Dayton, Ohio), 34 12, 2825-2839

Kurita, Hisaka; Carreira, Vinicius S; Fan, Yunxia; Jiang, Min; Naticchioni, Mindi; Koch, Sheryl; Rubinstein, Jack; Puga, Alvaro 2016. Ah receptor expression in cardiomyocytes protects adult female mice from heart dysfunction induced by TCDD exposure. Toxicology, 355-356 , 9-20

Li, Yue; Xie, Changchun; Murphy, Susan K; Skaar, David; Nye, Monica; Vidal, Adriana C; Cecil, Kim M; Dietrich, Kim N; Puga, Alvaro; Jirtle, Randy L; Hoyo, Cathrine 2016. Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. Environmental health perspectives, 124 5, 666-73

Wang, Qin; Kurita, Hisaka; Carreira, Vinicius; Ko, Chia-I; Fan, Yunxia; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Puga, Alvaro 2016. Ah Receptor Activation by Dioxin Disrupts Activin, BMP, and WNT Signals During the Early Differentiation of Mouse Embryonic Stem Cells and Inhibits Cardiomyocyte Functions. Toxicological sciences : an official journal of the Society of Toxicology, 149 2, 346-57

Carreira, Vinicius S; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult. PloS one, 10 11, e0142440

Carreira, Vinicius S; Fan, Yunxia; Wang, Qing; Zhang, Xiang; Kurita, Hisaka; Ko, Chia-I; Naticchioni, Mindi; Jiang, Min; Koch, Sheryl; Medvedovic, Mario; Xia, Ying; Rubinstein, Jack; Puga, Alvaro 2015. Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes. Toxicological sciences : an official journal of the Society of Toxicology, 147 2, 425-35

Cox, Timothy M; Drelichman, Guillermo; Cravo, Renata; Balwani, Manisha; Burrow, Thomas Andrew; Martins, Ana Maria; Lukina, Elena; Rosenbloom, Barry; Ross, Leorah; Angell, Jennifer; Puga, Ana Cristina 2015. Eliglustat compared with imiglucerase in patients with Gaucher's disease type 1 stabilised on enzyme replacement therapy: a phase 3, randomised, open-label, non-inferiority trial. Lancet (London, England), 385 9985, 2355-62

Lindquist, Diana M; Beckwith, Travis; Cecil, Kim M; Sánchez-Martín, Francisco Javier; Landero-Figueroa, Julio; Puga, Alvaro 2015. Prenatal and early postnatal lead exposure in mice: neuroimaging findings. Quantitative imaging in medicine and surgery, 5 4, 511-8

Mongan, Maureen; Meng, Qinghang; Wang, Jingjing; Kao, Winston W-Y; Puga, Alvaro; Xia, Ying 2015. Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis. The Journal of biological chemistry, 290 32, 19770-9

Sánchez-Martín, Francisco Javier; Fan, Yunxia; Carreira, Vinicius; Ovesen, Jerald L; Vonhandorf, Andrew; Xia, Ying; Puga, Alvaro 2015. Long-term Coexposure to Hexavalent Chromium and B[a]P Causes Tissue-Specific Differential Biological Effects in Liver and Gastrointestinal Tract of Mice. Toxicological sciences : an official journal of the Society of Toxicology, 146 1, 52-64

Sánchez-Martín, Francisco Javier; Lindquist, Diana M; Landero-Figueroa, Julio; Zhang, Xiang; Chen, Jing; Cecil, Kim M; Medvedovic, Mario; Puga, Alvaro 2015. Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead. Neurotoxicology, 46 , 92-100

Winans, Bethany; Nagari, Anusha; Chae, Minho; Post, Christina M; Ko, Chia-I; Puga, Alvaro; Kraus, W Lee; Lawrence, B Paige 2015. Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses. Journal of immunology (Baltimore, Md. : 1950), 194 9, 4446-57

Ko, Chia-I; Wang, Qin; Fan, Yunxia; Xia, Ying; Puga, Alvaro 2014. Pluripotency factors and Polycomb Group proteins repress aryl hydrocarbon receptor expression in murine embryonic stem cells. Stem cell research, 12 1, 296-308

Kurita, Hisaka; Schnekenburger, Michael; Ovesen, Jerald L; Xia, Ying; Puga, Alvaro 2014. The Ah receptor recruits IKK? to its target binding motifs to phosphorylate serine-10 in histone H3 required for transcriptional activation. Toxicological sciences : an official journal of the Society of Toxicology, 139 1, 121-32

Ovesen, Jerald L; Fan, Yunxia; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyrene. Toxicology, 316 , 14-24

Ovesen, Jerald L; Fan, Yunxia; Zhang, Xiang; Chen, Jing; Medvedovic, Mario; Xia, Ying; Puga, Alvaro 2014. Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure. PloS one, 9 5, e97849

Sánchez-Martín, Francisco Javier; Fan, Yunxia; Lindquist, Diana M; Xia, Ying; Puga, Alvaro 2013. Lead induces similar gene expression changes in brains of gestationally exposed adult mice and in neurons differentiated from mouse embryonic stem cells. PloS one, 8 11, e80558

Fan, Yunxia; Ovesen, Jerald L; Puga, Alvaro 2012. Long-term exposure to hexavalent chromium inhibits expression of tumor suppressor genes in cultured cells and in mice. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 26 2-3, 188-91

Wang, Jingcai; Chen, Liang; Ko, Chia-I; Zhang, Lin; Puga, Alvaro; Xia, Ying 2012. Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation. The Journal of biological chemistry, 287 4, 2787-97

Geh, Esmond; Meng, Qinghang; Mongan, Maureen; Wang, Jingcai; Takatori, Atsushi; Zheng, Yi; Puga, Alvaro; Lang, Richard A; Xia, Ying 2011. Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proceedings of the National Academy of Sciences of the United States of America, 108 42, 17349-54

Ovesen, Jerald L; Schnekenburger, Michael; Puga, Alvaro 2011. Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin. Toxicological sciences : an official journal of the Society of Toxicology, 121 1, 123-31

Puga, Alvaro 2011. Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease. Toxicological sciences : an official journal of the Society of Toxicology, 120 2, 256-61

Fan, Yunxia; Boivin, Gregory P; Knudsen, Erik S; Nebert, Daniel W; Xia, Ying; Puga, Alvaro 2010. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer research, 70 1, 212-20

Peng, Zhimin; Geh, Esmond; Chen, Liang; Meng, Qinghang; Fan, Yunxia; Sartor, Maureen; Shertzer, Howard G; Liu, Zheng-Gang; Puga, Alvaro; Xia, Ying 2010. Inhibitor of kappaB kinase beta regulates redox homeostasis by controlling the constitutive levels of glutathione. Molecular pharmacology, 77 5, 784-92

Reichard, John F; Puga, Alvaro 2010. Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics, 2 1, 87-104

Wang, Ying; Fan, Yunxia; Puga, Alvaro 2010. Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes. Toxicological sciences : an official journal of the Society of Toxicology, 115 1, 225-37

Chen, Liang; Ovesen, Jerald L; Puga, Alvaro; Xia, Ying 2009. Distinct contributions of JNK and p38 to chromium cytotoxicity and inhibition of murine embryonic stem cell differentiation. Environmental health perspectives, 117 7, 1124-30

Ma, Ci; Marlowe, Jennifer L; Puga, Alvaro 2009. The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways. EXS, 99 , 231-57

Puga, Alvaro; Ma, Ci; Marlowe, Jennifer L 2009. The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways. Biochemical pharmacology, 77 4, 713-22

Sartor, Maureen A; Schnekenburger, Michael; Marlowe, Jennifer L; Reichard, John F; Wang, Ying; Fan, Yunxia; Ma, Ci; Karyala, Saikumar; Halbleib, Danielle; Liu, Xiangdong; Medvedovic, Mario; Puga, Alvaro 2009. Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs. Environmental health perspectives, 117 7, 1139-46

Marlowe, Jennifer L; Fan, Yunxia; Chang, Xiaoqing; Peng, Li; Knudsen, Erik S; Xia, Ying; Puga, Alvaro 2008. The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Molecular biology of the cell, 19 8, 3263-71

Peng, Li; Mayhew, Christopher N; Schnekenburger, Michael; Knudsen, Erik S; Puga, Alvaro 2008. Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors. Toxicology, 246 2-3, 242-7

Reichard, John F; Sartor, Maureen A; Puga, Alvaro 2008. BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. The Journal of biological chemistry, 283 33, 22363-70

Chang, Xiaoqing; Fan, Yunxia; Karyala, Saikumar; Schwemberger, Sandy; Tomlinson, Craig R; Sartor, Maureen A; Puga, Alvaro 2007. Ligand-independent regulation of transforming growth factor beta1 expression and cell cycle progression by the aryl hydrocarbon receptor. Molecular and cellular biology, 27 17, 6127-39

Reichard, John F; Motz, Gregory T; Puga, Alvaro 2007. Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1. Nucleic acids research, 35 21, 7074-86

Reichard, John F; Schnekenburger, Michael; Puga, Alvaro 2007. Long term low-dose arsenic exposure induces loss of DNA methylation. Biochemical and biophysical research communications, 352 1, 188-92

Schnekenburger, Michael; Talaska, Glenn; Puga, Alvaro 2007. Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. Molecular and cellular biology, 27 20, 7089-101

Genter, Mary Beth; Marlowe, Jennifer; Kevin Kerzee, J; Dragin, Nadine; Puga, Alvaro; Dalton, Timothy P; Nebert, Daniel W 2006. Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochemical and biophysical research communications, 348 1, 120-3

Reichard, John F; Dalton, Timothy P; Shertzer, Howard G; Puga, Alvaro 2006. Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor. Dose-response : a publication of International Hormesis Society, 3 3, 306-31

Singleton, David W; Feng, Yuxin; Yang, Jun; Puga, Alvaro; Lee, Adrian V; Khan, Sohaib A 2006. Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environmental research, 100 1, 86-92

Talaska, Glenn; Ginsburg, David; LaDow, Kathy; Puga, Alvaro; Dalton, Timothy; Warshawsky, David 2006. Impact of Cyp1a2 or Ahr gene knockout in mice: implications for biomonitoring studies. Toxicology letters, 162 2-3, 246-9

Kann, Simone; Estes, Cameron; Reichard, John F; Huang, Ming-Ya; Sartor, Maureen A; Schwemberger, Sandy; Chen, Ying; Dalton, Timothy P; Shertzer, Howard G; Xia, Ying; Puga, Alvaro 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicological sciences : an official journal of the Society of Toxicology, 87 2, 365-84

Kann, Simone; Huang, Ming-Ya; Estes, Cameron; Reichard, John F; Sartor, Maureen A; Xia, Ying; Puga, Alvaro 2005. Arsenite-induced aryl hydrocarbon receptor nuclear translocation results in additive induction of phase I genes and synergistic induction of phase II genes. Molecular pharmacology, 68 2, 336-46

Marlowe, Jennifer L; Puga, Alvaro 2005. Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. Journal of cellular biochemistry, 96 6, 1174-84

Puga, Alvaro; Tomlinson, Craig R; Xia, Ying 2005. Ah receptor signals cross-talk with multiple developmental pathways. Biochemical pharmacology, 69 2, 199-207

Barnes-Ellerbe, Sonya; Knudsen, Karen E; Puga, Alvaro 2004. 2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation. Molecular pharmacology, 66 3, 502-11

Guo, Junhai; Sartor, Maureen; Karyala, Saikumar; Medvedovic, Mario; Kann, Simone; Puga, Alvaro; Ryan, Patrick; Tomlinson, Craig R 2004. Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicology and applied pharmacology, 194 1, 79-89

Karyala, Saikumar; Guo, Junhai; Sartor, Maureen; Medvedovic, Mario; Kann, Simone; Puga, Alvaro; Ryan, Patrick; Tomlinson, Craig R 2004. Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice. Cardiovascular toxicology, 4 1, 47-73

Marlowe, Jennifer L; Knudsen, Erik S; Schwemberger, Sandy; Puga, Alvaro 2004. The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression. The Journal of biological chemistry, 279 28, 29013-22

Puga, Alvaro; Sartor, Maureen A; Huang, Ming-Ya; Kerzee, J Kevin; Wei, Yu-Dan; Tomlinson, Craig R; Baxter, C Stuart; Medvedovic, Mario 2004. Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet show common responses to dioxin exposure. Cardiovascular toxicology, 4 4, 385-404

Singleton, David W; Feng, Yuxin; Chen, Yangde; Busch, Steve J; Lee, Adrian V; Puga, Alvaro; Khan, Sohaib A 2004. Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Molecular and cellular endocrinology, 221 1-2, 47-55

Tan, Zongqing; Huang, Mingya; Puga, Alvaro; Xia, Ying 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicological sciences : an official journal of the Society of Toxicology, 82 1, 80-7

Vonderheide, Anne P; Meija, Juris; Tepperman, Katherine; Puga, Alvaro; Pinhas, Allan R; States, J Christopher; Caruso, Joseph A 2004. Retention of Cr(III) by high-performance chelation ion chromatography interfaced to inductively-coupled plasma mass spectrometric detection with collision cell. Journal of chromatography. A, 1024 1-2, 129-37

Wei, Yu-Dan; Tepperman, Katherine; Huang, Ming-ya; Sartor, Maureen A; Puga, Alvaro 2004. Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. The Journal of biological chemistry, 279 6, 4110-9

Dalton, Timothy P; Puga, Alvaro; Shertzer, Howard G 2002. Induction of cellular oxidative stress by aryl hydrocarbon receptor activation. Chemico-biological interactions, 141 1-2, 77-95

Maier, Andrew; Schumann, Brenda L; Chang, Xiaoqing; Talaska, Glenn; Puga, Alvaro 2002. Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity. Mutation research, 517 1-2, 101-11

Puga, Alvaro; Marlowe, Jennifer; Barnes, Sonya; Chang, Ching-yi; Maier, Andrew; Tan, Zongqing; Kerzee, J Kevin; Chang, Xaoqing; Strobeck, Matt; Knudsen, Erik S 2002. Role of the aryl hydrocarbon receptor in cell cycle regulation. Toxicology, 181-182 , 171-7

Puga, Alvaro; Xia, Ying; Elferink, Cornelis 2002. Role of the aryl hydrocarbon receptor in cell cycle regulation. Chemico-biological interactions, 141 1-2, 117-30

Senft, Albert P; Dalton, Timothy P; Nebert, Daniel W; Genter, Mary Beth; Puga, Alvaro; Hutchinson, Richard J; Kerzee, J Kevin; Uno, Shigeyuki; Shertzer, Howard G 2002. Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free radical biology & medicine, 33 9, 1268-78

Tan, Zongqing; Chang, Xiaoqing; Puga, Alvaro; Xia, Ying 2002. Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochemical pharmacology, 64 5-6, 771-80

Wetherill, Yelena B; Petre, Christin E; Monk, Kelly R; Puga, Alvaro; Knudsen, Karen E 2002. The xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells. Molecular cancer therapeutics, 1 7, 515-24

Dalton, T P; Kerzee, J K; Wang, B; Miller, M; Dieter, M Z; Lorenz, J N; Shertzer, H G; Nerbert, D W; Puga, A 2001. Dioxin exposure is an environmental risk factor for ischemic heart disease. Cardiovascular toxicology, 1 4, 285-98

Maier, A; Dalton, T P; Puga, A 2000. Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic. Molecular carcinogenesis, 28 4, 225-35

Puga, A; Barnes, S J; Chang, C; Zhu, H; Nephew, K P; Khan, S A; Shertzer, H G 2000. Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemical pharmacology, 59 8, 997-1005

Puga, A; Barnes, S J; Dalton, T P; Chang, C y; Knudsen, E S; Maier, M A 2000. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. The Journal of biological chemistry, 275 4, 2943-50

Puga, A; Maier, A; Medvedovic, M 2000. The transcriptional signature of dioxin in human hepatoma HepG2 cells. Biochemical pharmacology, 60 8, 1129-42

Strobeck, M W; Fribourg, A F; Puga, A; Knudsen, E S 2000. Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest. Oncogene, 19 15, 1857-67

Carvan, ; Ponomareva, ; Solis, ; Matlib, ; Puga, ; Nebert, 1999. Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins. Marine biotechnology (New York, N.Y.), 1 2, 155-166

Dalton, T P; Shertzer, H G; Puga, A 1999. Regulation of gene expression by reactive oxygen. Annual review of pharmacology and toxicology, 39 , 67-101

Shertzer, H G; Puga, A; Chang, C; Smith, P; Nebert, D W; Setchell, K D; Dalton, T P 1999. Inhibition of CYP1A1 enzyme activity in mouse hepatoma cell culture by soybean isoflavones. Chemico-biological interactions, 123 1, 31-49

Vasiliou, V; Reuter, S F; Williams, S; Puga, A; Nebert, D W 1999. Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression. Pharmacogenetics, 9 5, 569-80

Chang, C Y; Puga, A 1998. Constitutive activation of the aromatic hydrocarbon receptor. Molecular and cellular biology, 18 1, 525-35

Fitzgerald, C T; Nebert, D W; Puga, A 1998. Regulation of mouse Ah receptor (Ahr) gene basal expression by members of the Sp family of transcription factors. DNA and cell biology, 17 9, 811-22

Shertzer, H G; Nebert, D W; Puga, A; Ary, M; Sonntag, D; Dixon, K; Robinson, L J; Cianciolo, E; Dalton, T P 1998. Dioxin causes a sustained oxidative stress response in the mouse. Biochemical and biophysical research communications, 253 1, 44-8

Micka, J; Milatovich, A; Menon, A; Grabowski, G A; Puga, A; Nebert, D W 1997. Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility. Pharmacogenetics, 7 2, 95-101

Puga, A; Hoffer, A; Zhou, S; Bohm, J M; Leikauf, G D; Shertzer, H G 1997. Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin. Biochemical pharmacology, 54 12, 1287-96

Puga, A; Nebert, D W; McKinnon, R A; Menon, A G 1997. Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance. Critical reviews in toxicology, 27 2, 199-222

FitzGerald, C T; Fernandez-Salguero, P; Gonzalez, F J; Nebert, D W; Puga, A 1996. Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins. Archives of biochemistry and biophysics, 333 1, 170-8

Hoffer, A; Chang, C Y; Puga, A 1996. Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. Toxicology and applied pharmacology, 141 1, 238-47

Liang, H C; Li, H; McKinnon, R A; Duffy, J J; Potter, S S; Puga, A; Nebert, D W 1996. Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. Proceedings of the National Academy of Sciences of the United States of America, 93 4, 1671-6

Nebert, D W; McKinnon, R A; Puga, A 1996. Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer. DNA and cell biology, 15 4, 273-80

Puga, A; Micka, J; Chang, C Y; Liang, H C; Nebert, D W 1996. Role of molecular biology in risk assessment. Advances in experimental medicine and biology, 387 , 395-404

Duh, J L; Zhu, H; Shertzer, H G; Nebert, D W; Puga, A 1995. The Y-box motif mediates redox-dependent transcriptional activation in mouse cells. The Journal of biological chemistry, 270 51, 30499-507

Vasiliou, V; Puga, A; Chang, C Y; Tabor, M W; Nebert, D W 1995. Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression. Biochemical pharmacology, 50 12, 2057-68

Yao, Y; Hoffer, A; Chang, C Y; Puga, A 1995. Dioxin activates HIV-1 gene expression by an oxidative stress pathway requiring a functional cytochrome P450 CYP1A1 enzyme. Environmental health perspectives, 103 4, 366-71

Carrier, F; Chang, C Y; Duh, J L; Nebert, D W; Puga, A 1994. Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT). Biochemical pharmacology, 48 9, 1767-78

Liu, R M; Vasiliou, V; Zhu, H; Duh, J L; Tabor, M W; Puga, A; Nebert, D W; Sainsbury, M; Shertzer, H G 1994. Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines. Carcinogenesis, 15 10, 2347-52

Vasiliou, V; Theurer, M J; Puga, A; Reuter, S F; Nebert, D W 1994. Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels. Pharmacogenetics, 4 6, 341-8

Chang, C; Smith, D R; Prasad, V S; Sidman, C L; Nebert, D W; Puga, A 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics, 3 6, 312-21

Nebert, D W; Puga, A; Vasiliou, V 1993. Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction. Annals of the New York Academy of Sciences, 685 , 624-40

Pilon, A L; Kozak, C A; Nebert, D W; Puga, A 1993. Localization of the murine Hmg1 gene, encoding an HMG-box protein, to mouse chromosome 2. Mammalian genome : official journal of the International Mammalian Genome Society, 4 10, 612-4

Vasiliou, V; Puga, A; Nebert, D W 1993. Mouse class 3 aldehyde dehydrogenases: positive and negative regulation of gene expression. Advances in experimental medicine and biology, 328 , 131-9

Carrier, F; Owens, R A; Nebert, D W; Puga, A 1992. Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation. Molecular and cellular biology, 12 4, 1856-63

Puga, A; Nebert, D W; Carrier, F 1992. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. DNA and cell biology, 11 4, 269-81

Puga, A; Raychaudhuri, B; Nebert, D W 1992. Transcriptional derepression of the murine Cyp1a-1 gene by mevinolin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 6 2, 777-85

Vasiliou, V; Puga, A; Nebert, D W 1992. Negative regulation of the murine cytosolic aldehyde dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2 proteins. Biochemical and biophysical research communications, 187 1, 413-9

Nebert, D W; Petersen, D D; Puga, A 1991. Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin. Pharmacogenetics, 1 2, 68-78

Puga, A; Nebert, D W 1990. Evolution of the P450 gene superfamily and regulation of the murine Cyp1a1 gene. Biochemical Society transactions, 18 1, 7-10

RayChaudhuri, B; Nebert, D W; Puga, A 1990. The murine Cyp1a-1 gene negatively regulates its own transcription and that of other members of the aromatic hydrocarbon-responsive [Ah] gene battery. Molecular endocrinology (Baltimore, Md.), 4 12, 1773-81

Shibata, M; Puga, A; Salata, K F; Bachurski, C J; Lerman, M I; Notkins, A L 1989. Expression of a viral gene in insulin-producing cell lines renders them susceptible to immunological destruction. Diabetologia, 32 10, 709-15

Nebert, D W; Jones, J E; Owens, J; Puga, A 1988. Evolution of the P450 gene superfamily. Progress in clinical and biological research, 274 , 557-76

Puga, A; Oates, E L 1987. Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase cDNA clones. Free radical research communications, 3 6, 337-46

Puga, A; Raychaudhuri, B; Salata, K; Zhang, Y H; Nebert, D W . Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity. DNA and cell biology, 9 6, 425-36

Schnekenburger, Michael; Peng, Li; Puga, Alvaro . HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation. Biochimica et biophysica acta, 1769 9-10, 569-78