Today is

Department of

Cancer Biology

Photo of  Jun-lin Guan, PhD

Jun-lin Guan, PhD

Department Chair, Professor

Education/Credentials
  • Bachelor's Degree: University of Science and Technology of China
  • Doctoral Degree: University of California at San Diego

Research/Clinical Interests

The goals of our research program are to understand the fundamental principles of cell signaling in the regulation of basic cellular functions in normal cell and developmental processes and to determine how the disruption of normal signaling pathways lead to diseases such as cancer.

Contact Information
  • Vontz Center for Molecular Studies
  • Room 3324
  • 3125 Eden Ave
  • Cincinnati, Ohio 45267
  • Office 513-558-0114
  • Fax 513-558-1190
  • Email jun-lin.guan@uc.edu

Peer Reviewed Publications

Display All

Gao, Chenxi; Chen, Guangming; Zhang, Dennis Han; Zhang, Judy; Kuan, Shih-Fan; Hu, Wenhuo; Esni, Farzad; Gao, Xuan; Guan, Jun-Lin; Chu, Edward; Hu, Jing 2019. PYK2 is involved in premalignant acinar cell reprogramming and pancreatic ductal adenocarcinoma maintenance by phosphorylating ?-cateninY654. Cellular and molecular gastroenterology and hepatology, ,

Ho, Wan Yun; Tai, Yee Kit; Chang, Jer-Cherng; Liang, Jason; Tyan, Sheue-Houy; Chen, Song; Guan, Jun-Lin; Zhou, Huilin; Shen, Han-Ming; Koo, Edward; Ling, Shuo-Chien 2019. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy, , 1-16

Huang, Huilin; Weng, Hengyou; Zhou, Keren; Wu, Tong; Zhao, Boxuan Simen; Sun, Mingli; Chen, Zhenhua; Deng, Xiaolan; Xiao, Gang; Auer, Franziska; Klemm, Lars; Wu, Huizhe; Zuo, Zhixiang; Qin, Xi; Dong, Yunzhu; Zhou, Yile; Qin, Hanjun; Tao, Shu; Du, Juan; Liu, Jun; Lu, Zhike; Yin, Hang; Mesquita, Ana; Yuan, Celvie L; Hu, Yueh-Chiang; Sun, Wenju; Su, Rui; Dong, Lei; Shen, Chao; Li, Chenying; Qing, Ying; Jiang, Xi; Wu, Xiwei; Sun, Miao; Guan, Jun-Lin; Qu, Lianghu; Wei, Minjie; Müschen, Markus; Huang, Gang; He, Chuan; Yang, Jianhua; Chen, Jianjun 2019. Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature, 567 7748, 414-419

Jeong, Kyuho; Kim, Jung-Hyun; Murphy, James M; Park, Hyeonsoo; Kim, Su-Jeong; Rodriguez, Yelitza; Kong, Hyunkyung; Choi, Chungsik; Guan, Jun-Lin; Taylor, Joan M; Lincoln, Thomas M; Gerthoffer, William T; Kim, Jun-Sub; Ahn, Eun-Young Erin; Schlaepfer, David D; Lim, Ssang-Taek Steve 2019. Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription. Circulation research, ,

Thomas, Neil; Choi, Han Kyoung; Wei, Xiaoxi; Wang, Li; Mishina, Yuji; Guan, Jun-Lin; Liu, Fei 2019. Autophagy Regulates Craniofacial Bone Acquisition. Calcified tissue international, ,

Zachari, Maria; Gudmundsson, Sigurdur R; Li, Ziyue; Manifava, Maria; Shah, Ronak; Smith, Matthew; Stronge, James; Karanasios, Eleftherios; Piunti, Caterina; Kishi-Itakura, Chieko; Vihinen, Helena; Jokitalo, Eija; Guan, Jun-Lin; Buss, Folma; Smith, Andrew M; Walker, Simon A; Eskelinen, Eeva-Liisa; Ktistakis, Nicholas T 2019. Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform. Developmental cell, ,

Chen, Qixin; Jin, Chengzhi; Shao, Xintian; Guan, Ruilin; Tian, Zhiqi; Wang, Chenran; Liu, Fei; Ling, Peixue; Guan, Jun-Lin; Ji, Liangnian; Wang, Fengshan; Chao, Hui; Diao, Jiajie 2018. Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore. Small (Weinheim an der Bergstrasse, Germany), 14 41, e1802166

Choi, Han Kyoung; Yuan, Hebao; Fang, Fang; Wei, Xiaoxi; Liu, Lu; Li, Qing; Guan, Jun-Lin; Liu, Fei 2018. Tsc1 regulates the balance between osteoblast and adipocyte differentiation through autophagy/Notch1/β-catenin cascade. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,

Huang, Huilin; Weng, Hengyou; Sun, Wenju; Qin, Xi; Shi, Hailing; Wu, Huizhe; Zhao, Boxuan Simen; Mesquita, Ana; Liu, Chang; Yuan, Celvie L; Hu, Yueh-Chiang; Hüttelmaier, Stefan; Skibbe, Jennifer R; Su, Rui; Deng, Xiaolan; Dong, Lei; Sun, Miao; Li, Chenying; Nachtergaele, Sigrid; Wang, Yungui; Hu, Chao; Ferchen, Kyle; Greis, Kenneth D; Jiang, Xi; Wei, Minjie; Qu, Lianghu; Guan, Jun-Lin; He, Chuan; Yang, Jianhua; Chen, Jianjun 2018. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nature cell biology, 20 3, 285-295

Liu, Bingjie; Du, Ruikai; Zhou, Lei; Xu, Jiahui; Chen, Song; Chen, Ji; Yang, Xiaoli; Liu, Dong-Xu; Shao, Zhi-Ming; Zhang, Lixing; Yu, Zuoren; Xie, Ni; Guan, Jun-Lin; Liu, Suling 2018. miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/?-Catenin Axis. Theranostics, 8 21, 5801-5813

Nwadike, Chinwendu; Williamson, Leon E; Gallagher, Laura E; Guan, Jun-Lin; Chan, Edmond Y W 2018. AMPK inhibits ULK1-dependent autophagosome formation and lysosomal acidification via distinct mechanisms. Molecular and cellular biology, ,

Ogawa, Michinaga; Matsuda, Ryuta; Takada, Naoki; Tomokiyo, Mikado; Yamamoto, Shouji; Shizukusihi, Sayaka; Yamaji, Toshiyuki; Yoshikawa, Yuko; Yoshida, Mitsutaka; Tanida, Isei; Koike, Masato; Murai, Miyo; Morita, Hidetoshi; Takeyama, Haruko; Ryo, Akihide; Guan, Jun-Lin; Yamamoto, Masahiro; Inoue, Jun-Ichiro; Yanagawa, Toru; Fukuda, Mitsunori; Kawabe, Hiroshi; Ohnishi, Makoto 2018. Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1 mediated K63-linked ubiquitination. Cellular microbiology, , e12846

Sun, Shaogang; Wu, Hsin-Jung; Guan, Jun-Lin 2018. Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice. Scientific reports, 8 1, 2550

Thiagarajan, Praveena S; Sinyuk, Maksim; Turaga, Soumya M; Mulkearns-Hubert, Erin E; Hale, James S; Rao, Vinay; Demelash, Abeba; Saygin, Caner; China, Arnab; Alban, Tyler J; Hitomi, Masahiro; Torre-Healy, Luke A; Alvarado, Alvaro G; Jarrar, Awad; Wiechert, Andrew; Adorno-Cruz, Valery; Fox, Paul L; Calhoun, Benjamin C; Guan, Jun-Lin; Liu, Huiping; Reizes, Ofer; Lathia, Justin D 2018. Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase. Nature communications, 9 1, 578

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin 2018. Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer. Autophagy, ,

Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi 2017. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy, 13 5, 955-966

He, Yun; Sun, Xiumei; Wang, Li; Mishina, Yuji; Guan, Jun-Lin; Liu, Fei 2017. Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene. Genesis (New York, N.Y. : 2000), ,

Martin, E E; Huang, W; Anwar, T; Arellano-Garcia, C; Burman, B; Guan, J-L; Gonzalez, M E; Kleer, C G 2017. MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas. Oncogene, 36 16, 2275-2285

Ruiz-Torres, Sasha J; Benight, Nancy M; Karns, Rebekah A; Lower, Elyse E; Guan, Jun-Lin; Waltz, Susan E 2017. HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling. Oncotarget, 8 35, 58918-58933

Wacker, Rahel; Eickel, Nina; Schmuckli-Maurer, Jacqueline; Annoura, Takeshi; Niklaus, Livia; Khan, Shahid M; Guan, Jun-Lin; Heussler, Volker T 2017. LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway. Cellular microbiology, ,

Wang, Bo; Iyengar, Rekha; Li-Harms, Xiujie; Joo, Joung Hyuck; Wright, Christopher; Lavado, Alfonso; Horner, Linda; Yang, Mao; Guan, Jun-Lin; Frase, Sharon; Green, Douglas R; Cao, Xinwei; Kundu, Mondira 2017. The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy, , 1-16

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin 2017. Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia. The Journal of cell biology, 216 8, 2581-2596

Xia, Houjun; Wang, Wei; Crespo, Joel; Kryczek, Ilona; Li, Wei; Wei, Shuang; Bian, Zhaoqun; Maj, Tomasz; He, Mingxiao; Liu, Rebecca J; He, Youwen; Rattan, Ramandeep; Munkarah, Adnan; Guan, Jun-Lin; Zou, Weiping 2017. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Science immunology, 2 17,

Yeo, Syn Kok; Guan, Jun-Lin 2017. Breast Cancer: Multiple Subtypes within a Tumor? Trends in cancer, 3 11, 753-760

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin 2016. Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes & development, 30 7, 856-69

Park, Sunmin; Buck, Michael D; Desai, Chandni; Zhang, Xin; Loginicheva, Ekaterina; Martinez, Jennifer; Freeman, Michael L; Saitoh, Tatsuya; Akira, Shizuo; Guan, Jun-Lin; He, You-Wen; Blackman, Marcia A; Handley, Scott A; Levine, Beth; Green, Douglas R; Reese, Tiffany A; Artyomov, Maxim N; Virgin, Herbert W 2016. Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation. Cell host & microbe, 19 1, 91-101

Santeford, Andrea; Wiley, Luke A; Park, Sunmin; Bamba, Sonya; Nakamura, Rei; Gdoura, Abdelaziz; Ferguson, Thomas A; Rao, P Kumar; Guan, Jun-Lin; Saitoh, Tatsuya; Akira, Shizuo; Xavier, Ramnik; Virgin, Herbert W; Apte, Rajendra S 2016. Impaired autophagy in macrophages promotes inflammatory eye disease. Autophagy, 12 10, 1876-1885

Sun, Chunhui; Yuan, Hebao; Wang, Li; Wei, Xiaoxi; Williams, Linford; Krebsbach, Paul H; Guan, Jun-Lin; Liu, Fei 2016. FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation By Enhancing Wnt Signaling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, ,

Sun, Shaogang; Guan, Jun-Lin 2016. Modeling lymphangiosarcoma in mice. Cell cycle (Georgetown, Tex.), , 0

Wagener, Brant M; Hu, Meng; Zheng, Anni; Zhao, Xueke; Che, Pulin; Brandon, Angela; Anjum, Naseem; Snapper, Scott; Creighton, Judy; Guan, Jun-Lin; Han, Qimei; Cai, Guo-Qiang; Han, Xiaosi; Pittet, Jean-Francois; Ding, Qiang 2016. Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 7, 2557-69

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin 2016. Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of cell biology, 212 5, 545-60

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin 2016. Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of cell biology, 212 7, 879

Yeo, Syn Kok; Guan, Jun-Lin 2016. Hierarchical heterogeneity in mammary tumors and its regulation by autophagy. Autophagy, 12 10, 1960-1961

Yeo, Syn Kok; Wen, Jian; Chen, Song; Guan, Jun-Lin 2016. Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling. Cancer research, 76 11, 3397-410

Fang, Fang; Sun, Shaogang; Wang, Li; Guan, Jun-Lin; Giovannini, Marco; Zhu, Yuan; Liu, Fei 2015. Neural Crest-Specific TSC1 Deletion in Mice Leads to Sclerotic Craniofacial Bone Lesion. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30 7, 1195-205

Martinez, Jennifer; Malireddi, R K Subbarao; Lu, Qun; Cunha, Larissa Dias; Pelletier, Stephane; Gingras, Sebastien; Orchard, Robert; Guan, Jun-Lin; Tan, Haiyan; Peng, Junmin; Kanneganti, Thirumala-Devi; Virgin, Herbert W; Green, Douglas R 2015. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nature cell biology, 17 7, 893-906

Sun, Shaogang; Chen, Song; Liu, Fei; Wu, Haige; McHugh, Jonathan; Bergin, Ingrid L; Gupta, Anita; Adams, Denise; Guan, Jun-Lin 2015. Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling. Cancer cell, 28 6, 758-72

Tai, Yu-Ling; Chu, Pei-Yu; Lai, I-Rue; Wang, Ming-Yang; Tseng, Hui-Yuan; Guan, Jun-Lin; Liou, Jun-Yang; Shen, Tang-Long 2015. An EGFR/Src-dependent beta-4 integrin/FAK complex contributes to malignancy of breast cancer. Scientific reports, 5 , 16408

Wei, Huijun; Guan, Jun-Lin 2015. Blocking tumor growth by targeting autophagy and SQSTM1 in vivo. Autophagy, 11 5, 854-5

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin 2015. Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis. Breast cancer research and treatment, 149 3, 619-29

Yao, Jingyu; Jia, Lin; Khan, Naheed; Lin, Chengmao; Mitter, Sayak K; Boulton, Michael E; Dunaief, Joshua L; Klionsky, Daniel J; Guan, Jun-Lin; Thompson, Debra A; Zacks, David N 2015. Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium. Autophagy, 11 6, 939-53

Chen, Yongqiang; Wei, Huijun; Liu, Fei; Guan, Jun-Lin 2014. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling. The Journal of biological chemistry, 289 2, 1164-73

Kim, Edward; Wang, Yuan; Kim, Sun-Jung; Bornhorst, Miriam; Jecrois, Emmanuelle S; Anthony, Todd E; Wang, Chenran; Li, Yi E; Guan, Jun-Lin; Murphy, Geoffrey G; Zhu, Yuan 2014. Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1. eLife, 3 ,

Qu, Hong; Tu, Yizeng; Guan, Jun-Lin; Xiao, Guozhi; Wu, Chuanyue 2014. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. The Journal of biological chemistry, 289 45, 31001-13

Wei, Huijun; Wang, Chenran; Croce, Carlo M; Guan, Jun-Lin 2014. p62/SQSTM1 synergizes with autophagy for tumor growth in vivo Genes & development, 28 11, 1204-16

Chen, Song; Guan, Jun-Lin 2013. Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer. Cancer discovery, 3 11, 1225-7

Fan, Huaping; Zhao, Xiaofeng; Sun, Shaogang; Luo, Ming; Guan, Jun-Lin 2013. Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. The Journal of biological chemistry, 288 5, 3322-33

Fujita, Naonobu; Morita, Eiji; Itoh, Takashi; Tanaka, Atsushi; Nakaoka, Megumi; Osada, Yuki; Umemoto, Tetsuo; Saitoh, Tatsuya; Nakatogawa, Hitoshi; Kobayashi, Shouhei; Haraguchi, Tokuko; Guan, Jun-Lin; Iwai, Kazuhiro; Tokunaga, Fuminori; Saito, Kazunobu; Ishibashi, Koutaro; Akira, Shizuo; Fukuda, Mitsunori; Noda, Takeshi; Yoshimori, Tamotsu 2013. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. The Journal of cell biology, 203 1, 115-28

Guan, Jun-Lin; Simon, Anna Katharina; Prescott, Mark; Menendez, Javier A; Liu, Fei; Wang, Fen; Wang, Chenran; Wolvetang, Ernst; Vazquez-Martin, Alejandro; Zhang, Jue 2013. Autophagy in stem cells. Autophagy, 9 6, 830-49

Hsieh, Yu-Hua; van der Heyde, Henri; Oh, Eok-Soo; Guan, Jun-Lin; Chang, Pi-Ling 2013. Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: An Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis. Molecular carcinogenesis, 54 5, 379-92

Jin, Yixin; Liu, Yang; Lin, Qiong; Li, Jieli; Druso, Joseph E; Antonyak, Marc A; Meininger, Cynthia J; Zhang, Shenyuan L; Dostal, David E; Guan, Jun-Lin; Cerione, Richard A; Peng, Xu 2013. Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Molecular and cellular biology, 33 21, 4181-97

Kim, Myungjin; Park, Hae Li; Park, Hwan-Woo; Ro, Seung-Hyun; Nam, Samuel G; Reed, John M; Guan, Jun-Lin; Lee, Jun Hee 2013. Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging. Autophagy, 9 8, 1201-13

Liu, Fei; Fang, Fang; Yuan, Hebao; Yang, Dongye; Chen, Yongqiang; Williams, Linford; Goldstein, Steven A; Krebsbach, Paul H; Guan, Jun-Lin 2013. Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 28 11, 2414-30

Luo, Ming; Zhao, Xiaofeng; Chen, Song; Liu, Suling; Wicha, Max S; Guan, Jun-Lin 2013. Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer research, 73 17, 5591-602

Ma, Di; Molusky, Matthew M; Song, Jianrui; Hu, Chun-Rui; Fang, Fang; Rui, Crystal; Mathew, Anna V; Pennathur, Subramaniam; Liu, Fei; Cheng, Ji-Xin; Guan, Jun-Lin; Lin, Jiandie D 2013. Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD. Molecular endocrinology (Baltimore, Md.), 27 10, 1643-54

Monastyrska, Iryna; Ulasli, Mustafa; Rottier, Peter J M; Guan, Jun-Lin; Reggiori, Fulvio; de Haan, Cornelis A M 2013. An autophagy-independent role for LC3 in equine arteritis virus replication. Autophagy, 9 2, 164-74

Patel, Khushbu K; Miyoshi, Hiroyuki; Beatty, Wandy L; Head, Richard D; Malvin, Nicole P; Cadwell, Ken; Guan, Jun-Lin; Saitoh, Tatsuya; Akira, Shizuo; Seglen, Per O; Dinauer, Mary C; Virgin, Herbert W; Stappenbeck, Thaddeus S 2013. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. The EMBO journal, 32 24, 3130-44

Peng, Xu; Lin, Qiong; Liu, Yang; Jin, Yixin; Druso, Joseph E; Antonyak, Marc A; Guan, Jun-Lin; Cerione, Richard A 2013. Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein & cell, 4 3, 231-42

Ritt, Michael; Guan, Jun Lin; Sivaramakrishnan, Sivaraj 2013. Visualizing and manipulating focal adhesion kinase regulation in live cells. The Journal of biological chemistry, 288 13, 8875-86

Schmidt, Tracy Thennes; Tauseef, Mohammad; Yue, Lili; Bonini, Marcelo G; Gothert, Joachim; Shen, Tang-Long; Guan, Jun-Lin; Predescu, Sanda; Sadikot, Ruxana; Mehta, Dolly 2013. Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities. American journal of physiology. Lung cellular and molecular physiology, 305 4, L291-300

Seong, Jihye; Tajik, Arash; Sun, Jie; Guan, Jun-Lin; Humphries, Martin J; Craig, Susan E; Shekaran, Asha; García, Andrés J; Lu, Shaoying; Lin, Michael Z; Wang, Ning; Wang, Yingxiao 2013. Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins. Proceedings of the National Academy of Sciences of the United States of America, 110 48, 19372-7

Wang, Chenran; Liang, Chun-Chi; Bian, Z Christine; Zhu, Yuan; Guan, Jun-Lin 2013. FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nature neuroscience, 16 5, 532-42

Cai, Guo-Qiang; Chou, Chu-Fang; Hu, Meng; Zheng, Anni; Reichardt, Louis F; Guan, Jun-Lin; Fang, Haotian; Luckhardt, Tracy R; Zhou, Yong; Thannickal, Victor J; Ding, Qiang 2012. Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of ?-smooth muscle actin filaments during myofibroblast differentiation. American journal of physiology. Lung cellular and molecular physiology, 303 8, L692-702

Chen, Xi; Li, Min; Chen, Daohong; Gao, Wentao; Guan, Jun-Lin; Komatsu, Massaki; Yin, Xiao-Ming 2012. Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis. PloS one, 7 12, e52347

Chen, Xiao Lei; Nam, Ju-Ock; Jean, Christine; Lawson, Christine; Walsh, Colin T; Goka, Erik; Lim, Ssang-Taek; Tomar, Alok; Tancioni, Isabelle; Uryu, Sean; Guan, Jun-Lin; Acevedo, Lisette M; Weis, Sara M; Cheresh, David A; Schlaepfer, David D 2012. VEGF-induced vascular permeability is mediated by FAK. Developmental cell, 22 1, 146-57

Petridou, Nicoletta I; Stylianou, Panayiota; Christodoulou, Neophytos; Rhoads, Daniel; Guan, Jun-Lin; Skourides, Paris A 2012. Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos. PloS one, 7 8, e42577

Wei, Huijun; Guan, Jun-Lin 2012. Pro-tumorigenic function of autophagy in mammary oncogenesis. Autophagy, 8 1, 129-31

Bae, Heekyong; Guan, Jun-Lin 2011. Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents. Molecular cancer research : MCR, 9 9, 1232-41

Fan, Huaping; Guan, Jun-Lin 2011. Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. The Journal of biological chemistry, 286 21, 18573-82

Kageyama, Shun; Omori, Hiroko; Saitoh, Tatsuya; Sone, Takefumi; Guan, Jun-Lin; Akira, Shizuo; Imamoto, Fumio; Noda, Takeshi; Yoshimori, Tamotsu 2011. The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella. Molecular biology of the cell, 22 13, 2290-300

Li, Xiao-Yan; Zhou, Xiaoming; Rowe, R Grant; Hu, Yuexian; Schlaepfer, David D; Ili?, Dusko; Dressler, Gregory; Park, Ann; Guan, Jun-Lin; Weiss, Stephen J 2011. Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells. The Journal of cell biology, 195 5, 729-38

Liu, Fei; Guan, Jun-Lin 2011. FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis. Autophagy, 7 2, 229-30

Peng, Xu; Guan, Jun-Lin 2011. Focal adhesion kinase: from in vitro studies to functional analyses in vivo. Current protein & peptide science, 12 1, 52-67

Seong, Jihye; Ouyang, Mingxing; Kim, Taejin; Sun, Jie; Wen, Po-Chao; Lu, Shaoying; Zhuo, Yue; Llewellyn, Nicholas M; Schlaepfer, David D; Guan, Jun-Lin; Chien, Shu; Wang, Yingxiao 2011. Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nature communications, 2 , 406

Wang, Dongyan; Olman, Mitchell A; Stewart, Jerry; Tipps, Russell; Huang, Ping; Sanders, Paul W; Toline, Eric; Prayson, Richard A; Lee, Jeongwu; Weil, Robert J; Palmer, Cheryl A; Gillespie, G Yancey; Liu, Wei Michael; Pieper, Russell O; Guan, Jun-Lin; Gladson, Candece L 2011. Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity. PloS one, 6 5, e19629

Wei, Huijun; Wei, Shuang; Gan, Boyi; Peng, Xu; Zou, Weiping; Guan, Jun-Lin 2011. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes & development, 25 14, 1510-27

Zhao, Xiaofeng; Guan, Jun-Lin 2011. Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Advanced drug delivery reviews, 63 8, 610-5

Ginestier, Christophe; Liu, Suling; Diebel, Mark E; Korkaya, Hasan; Luo, Ming; Brown, Marty; Wicinski, Julien; Cabaud, Olivier; Charafe-Jauffret, Emmanuelle; Birnbaum, Daniel; Guan, Jun-Lin; Dontu, Gabriela; Wicha, Max S 2010. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. The Journal of clinical investigation, 120 2, 485-97

Guan, Jun-Lin 2010. Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB life, 62 4, 268-76

Liang, Chun-Chi; Wang, Chenran; Peng, Xu; Gan, Boyi; Guan, Jun-Lin 2010. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. The Journal of biological chemistry, 285 5, 3499-509

Liu, Fei; Lee, Jae Y; Wei, Huijun; Tanabe, Osamu; Engel, James D; Morrison, Sean J; Guan, Jun-Lin 2010. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood, 116 23, 4806-14

Luo, Ming; Guan, Jun-Lin 2010. Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer letters, 289 2, 127-39

Ma, Hong; Togawa, Akashi; Soda, Keita; Zhang, Junhui; Lee, Sik; Ma, Ming; Yu, Zhiheng; Ardito, Thomas; Czyzyk, Jan; Diggs, Lonnette; Joly, Dominique; Hatakeyama, Shinji; Kawahara, Eiji; Holzman, Lawrence; Guan, Jun Lin; Ishibe, Shuta 2010. Inhibition of podocyte FAK protects against proteinuria and foot process effacement. Journal of the American Society of Nephrology : JASN, 21 7, 1145-56

Wang, Chenran; Yoo, Youngdong; Fan, Huaping; Kim, Eunjung; Guan, Kun-Liang; Guan, Jun-Lin 2010. Regulation of Integrin ? 1 recycling to lipid rafts by Rab1a to promote cell migration. The Journal of biological chemistry, 285 38, 29398-405

Yoo, Y; Ho, H J; Wang, C; Guan, J-L 2010. Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway. Oncogene, 29 2, 263-72

Zhao, Xiaofeng; Peng, Xu; Sun, Shaogang; Park, Ann Y J; Guan, Jun-Lin 2010. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. The Journal of cell biology, 189 6, 955-65

Chu, Pei-Yu; Huang, Ling-Ya; Hsu, Chun-Hua; Liang, Chun-Chi; Guan, Jun-Lin; Hung, Ting-Hsuan; Shen, Tang-Long 2009. Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis. The Journal of biological chemistry, 284 30, 20215-26

Hosokawa, Nao; Hara, Taichi; Kaizuka, Takeshi; Kishi, Chieko; Takamura, Akito; Miura, Yutaka; Iemura, Shun-ichiro; Natsume, Tohru; Takehana, Kenji; Yamada, Naoyuki; Guan, Jun-Lin; Oshiro, Noriko; Mizushima, Noboru 2009. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Molecular biology of the cell, 20 7, 1981-91

Luo, Ming; Fan, Huaping; Nagy, Tamas; Wei, Huijun; Wang, Chenran; Liu, Suling; Wicha, Max S; Guan, Jun-Lin 2009. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer research, 69 2, 466-74

Park, Ann Y J; Shen, Tang-Long; Chien, Shu; Guan, Jun-Lin 2009. Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis. The Journal of biological chemistry, 284 14, 9418-25

Wei, Huijun; Gan, Boyi; Wu, Xiaoyang; Guan, Jun-Lin 2009. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. The Journal of biological chemistry, 284 9, 6004-13

Zhao, Jihe; Guan, Jun-Lin 2009. Signal transduction by focal adhesion kinase in cancer. Cancer metastasis reviews, 28 1-2, 35-49

Bechara, Ahmad; Nawabi, Homaira; Moret, Frédéric; Yaron, Avraham; Weaver, Eli; Bozon, Muriel; Abouzid, Karima; Guan, Jun-Lin; Tessier-Lavigne, Marc; Lemmon, Vance; Castellani, Valérie 2008. FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. The EMBO journal, 27 11, 1549-62

Gan, Boyi; Guan, Jun-Lin 2008. FIP200, a key signaling node to coordinately regulate various cellular processes. Cellular signalling, 20 5, 787-94

Hara, Taichi; Takamura, Akito; Kishi, Chieko; Iemura, Shun-Ichiro; Natsume, Tohru; Guan, Jun-Lin; Mizushima, Noboru 2008. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. The Journal of cell biology, 181 3, 497-510

Martin, Nadine; Schwamborn, Klaus; Urlaub, Henning; Gan, Boyi; Guan, Jun-Lin; Dejean, Anne 2008. Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity. Molecular and cellular biology, 28 8, 2771-81

Peng, Xu; Wu, Xiaoyang; Druso, Joseph E; Wei, Huijun; Park, Ann Yong-Jin; Kraus, Marc S; Alcaraz, Ana; Chen, Ju; Chien, Shu; Cerione, Richard A; Guan, Jun-Lin 2008. Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proceedings of the National Academy of Sciences of the United States of America, 105 18, 6638-43

Weis, Sara M; Lim, Ssang-Taek; Lutu-Fuga, Kimberly M; Barnes, Leo A; Chen, Xiao Lei; Göthert, Joachim R; Shen, Tang-Long; Guan, Jun-Lin; Schlaepfer, David D; Cheresh, David A 2008. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. The Journal of cell biology, 181 1, 43-50

Xie, Jianjun; Allen, Krystal H; Marguet, Amelia; Berghorn, Kathie A; Bliss, Stuart P; Navratil, Amy M; Guan, Jun Lin; Roberson, Mark S 2008. Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormone. Molecular endocrinology (Baltimore, Md.), 22 10, 2322-35

Liang, Chun-Chi; Park, Ann Y; Guan, Jun-Lin 2007. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nature protocols, 2 2, 329-33

Nagy, Tamas; Wei, Huijun; Shen, Tang-Long; Peng, Xu; Liang, Chun-Chi; Gan, Boyi; Guan, Jun-Lin 2007. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. The Journal of biological chemistry, 282 43, 31766-76

Rhoads, Daniel S; Guan, Jun-Lin 2007. Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules. Experimental cell research, 313 18, 3859-67

Yoo, Youngdong; Wu, Xiaoyang; Guan, Jun-Lin 2007. A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. The Journal of biological chemistry, 282 10, 7616-23

Feng, Qiyu; Baird, Dan; Peng, Xu; Wang, Jianbin; Ly, Thi; Guan, Jun-Lin; Cerione, Richard A 2006. Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nature cell biology, 8 9, 945-56

Gan, Boyi; Peng, Xu; Nagy, Tamas; Alcaraz, Ana; Gu, Hua; Guan, Jun-Lin 2006. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. The Journal of cell biology, 175 1, 121-33

Gan, Boyi; Yoo, Youngdong; Guan, Jun-Lin 2006. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. The Journal of biological chemistry, 281 49, 37321-9

Peng, Xu; Kraus, Marc S; Wei, Huijun; Shen, Tang-Long; Pariaut, Romain; Alcaraz, Ana; Ji, Guangju; Cheng, Lihong; Yang, Qinglin; Kotlikoff, Michael I; Chen, Ju; Chien, Kenneth; Gu, Hua; Guan, Jun-Lin 2006. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. The Journal of clinical investigation, 116 1, 217-27

Wei, Huijun; Wang, Xianhui; Gan, Boyi; Urvalek, Alison M; Melkoumian, Zara K; Guan, Jun-Lin; Zhao, Jihe 2006. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. The Journal of biological chemistry, 281 24, 16664-71

Wu, Xiaoyang; Yoo, Youngdong; Okuhama, Nataly N; Tucker, Philip W; Liu, Gang; Guan, Jun-Lin 2006. Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nature cell biology, 8 7, 756-63

Yoo, Youngdong; Wu, Xiaoyang; Egile, Coumaran; Li, Rong; Guan, Jun-Lin 2006. Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading. The Journal of biological chemistry, 281 22, 15352-60

Cohen, Lee Ann; Guan, Jun-Lin 2005. Mechanisms of focal adhesion kinase regulation. Current cancer drug targets, 5 8, 629-43

Cohen, Lee Ann; Guan, Jun-Lin 2005. Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation. The Journal of biological chemistry, 280 9, 8197-207

Ding, Qiang; Grammer, J Robert; Nelson, Mark A; Guan, Jun-Lin; Stewart, Jerry E; Gladson, Candece L 2005. p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. The Journal of biological chemistry, 280 8, 6802-15

Gan, Boyi; Melkoumian, Zara K; Wu, Xiaoyang; Guan, Kun-Liang; Guan, Jun-Lin 2005. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. The Journal of cell biology, 170 3, 379-89

Li, Song; Guan, Jun-Lin; Chien, Shu 2005. Biochemistry and biomechanics of cell motility. Annual review of biomedical engineering, 7 , 105-50

Melkoumian, Zara K; Peng, Xu; Gan, Boyi; Wu, Xiaoyang; Guan, Jun-Lin 2005. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer research, 65 15, 6676-84

Miao, Hui; Strebhardt, Klaus; Pasquale, Elena B; Shen, Tang-Long; Guan, Jun-Lin; Wang, Bingcheng 2005. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. The Journal of biological chemistry, 280 2, 923-32

Moon, James J; Matsumoto, Melissa; Patel, Shyam; Lee, Luke; Guan, Jun-Lin; Li, Song 2005. Role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransduction. Journal of cellular physiology, 203 1, 166-76

Pongchairerk, Urai; Guan, Jun-Lin; Leardkamolkarn, Vijittra 2005. Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1. World journal of gastroenterology : WJG, 11 37, 5845-52

Rhoads, Daniel S; Nadkarni, Sharvari M; Song, Loling; Voeltz, Camilla; Bodenschatz, Eberhard; Guan, Jun-Lin 2005. Using microfluidic channel networks to generate gradients for studying cell migration. Methods in molecular biology (Clifton, N.J.), 294 , 347-57

Rodriguez, Luis G; Guan, Jun-Lin 2005. 14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove. Journal of cellular physiology, 202 1, 285-94

Rodriguez, Luis G; Wu, Xiaoyang; Guan, Jun-Lin 2005. Wound-healing assay. Methods in molecular biology (Clifton, N.J.), 294 , 23-9

Shen, Tang-Long; Park, Ann Y-J; Alcaraz, Ana; Peng, Xu; Jang, Ihnkyung; Koni, Pandelakis; Flavell, Richard A; Gu, Hua; Guan, Jun-Lin 2005. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. The Journal of cell biology, 169 6, 941-52

Wu, Xiaoyang; Gan, Boyi; Yoo, Youngdong; Guan, Jun-Lin 2005. FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Developmental cell, 9 2, 185-96

Guan, Jun-Lin 2004. Cell biology. Integrins, rafts, Rac, and Rho. Science (New York, N.Y.), 303 5659, 773-4

Li, Weiquan; Lee, Jeeyong; Vikis, Haris G; Lee, Seung-Hee; Liu, Guofa; Aurandt, Jennifer; Shen, Tang-Long; Fearon, Eric R; Guan, Jun-Lin; Han, Min; Rao, Yi; Hong, Kyonsoo; Guan, Kun-Liang 2004. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nature neuroscience, 7 11, 1213-21

Peng, Xu; Ueda, Hiroki; Zhou, Hongming; Stokol, Tracy; Shen, Tang-Long; Alcaraz, Ana; Nagy, Tamas; Vassalli, Jean-Dominique; Guan, Jun-Lin 2004. Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovascular research, 64 3, 421-30

Shen, Tang-Long; Guan, Jun-Lin 2004. Grb7 in intracellular signaling and its role in cell regulation. Frontiers in bioscience : a journal and virtual library, 9 , 192-200

Wu, Xiaoyang; Suetsugu, Shiro; Cooper, Lee Ann; Takenawa, Tadaomi; Guan, Jun-Lin 2004. Focal adhesion kinase regulation of N-WASP subcellular localization and function. The Journal of biological chemistry, 279 10, 9565-76

Cooper, Lee Ann; Shen, Tang-Long; Guan, Jun-Lin 2003. Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Molecular and cellular biology, 23 22, 8030-41

Zhao, Jihe; Bian, Z Christine; Yee, Kristine; Chen, Benjamin P C; Chien, Shu; Guan, Jun-Lin 2003. Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Molecular cell, 11 6, 1503-15

Abbi, Smita; Ueda, Hiroki; Zheng, Chuanhai; Cooper, Lee Ann; Zhao, Jihe; Christopher, Renee; Guan, Jun-Lin 2002. Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. Molecular biology of the cell, 13 9, 3178-91

Goicoechea, Silvia M; Tu, Yizeng; Hua, Yun; Chen, Ka; Shen, Tang-Long; Guan, Jun-Lin; Wu, Chuanyue 2002. Nck-2 interacts with focal adhesion kinase and modulates cell motility. The international journal of biochemistry & cell biology, 34 7, 791-805

Han, Dong Cho; Shen, Tang-Long; Miao, Hui; Wang, Bingcheng; Guan, Jun-Lin 2002. EphB1 associates with Grb7 and regulates cell migration. The Journal of biological chemistry, 277 47, 45655-61

Li, Song; Butler, Peter; Wang, Yingxiao; Hu, Yingli; Han, Dong Cho; Usami, Shunichi; Guan, Jun-Lin; Chien, Shu 2002. The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proceedings of the National Academy of Sciences of the United States of America, 99 6, 3546-51

Shen, Tang-Long; Han, Dong Cho; Guan, Jun-Lin 2002. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. The Journal of biological chemistry, 277 32, 29069-77