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Department of

Surgery

Photo of  Erich Gulbins, MD, PhD

Erich Gulbins, MD, PhD

Volunteer Professor of Surgery

Education/Credentials
  • Medical Degree: University of Heidelberg
  • Doctoral Degree: University of Heidelberg
  • Postdoctoral Fellowship: La Jolla Institute for Allergy and Immunology

Contact Information
  • Medical Sciences Building
  • SRU Room G479
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-8673
  • Email erich.gulbins@uc.edu

Peer Reviewed Publications

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Becker, Katrin Anne; Fahsel, Björn; Kemper, Hannes; Mayeres, Joelina; Li, Cao; Wilker, Barbara; Keitsch, Simone; Soddemann, Matthias; Sehl, Carolin; Kohnen, Marcus; Edwards, Michael J; Grassmé, Heike; Caldwell, Charles C; Seitz, Aaron; Fraunholz, Martin; Gulbins, Erich 2018. Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide. Infection and immunity, 86 1,

Becker, Katrin Anne; Riethmüller, Joachim; Seitz, Aaron P; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C; Edwards, Michael J; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich 2018. Sphingolipids as targets for inhalation treatment of cystic fibrosis. Advanced drug delivery reviews, ,

Kalinichenko, Liubov S; Gulbins, Erich; Kornhuber, Johannes; Müller, Christian P 2018. The role of sphingolipids in psychoactive drug use and addiction. Journal of neural transmission (Vienna, Austria : 1996), 125 4, 651-672

Keitsch, Simone; Riethmüller, Joachim; Soddemann, Matthias; Sehl, Carolin; Wilker, Barbara; Edwards, Michael J; Caldwell, Charles C; Fraunholz, Martin; Gulbins, Erich; Becker, Katrin Anne 2018. Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-toxin. Biological chemistry, ,

Kim, Young; Abplanalp, William A; Jung, Andrew D; Schuster, Rebecca M; Lentsch, Alex B; Gulbins, Erich; Caldwell, Charles C; Pritts, Timothy A 2018. Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5. Shock (Augusta, Ga.), 49 3, 288-294

Li, Pin-Lan; Gulbins, Erich 2018. Bioactive Lipids and Redox Signaling: Molecular Mechanism and Disease Pathogenesis. Antioxidants & redox signaling, ,

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Kim, Young; Goetzman, Holly S; Veile, Rosalie E; Gulbins, Erich; Goodman, Michael D; Nomellini, Vanessa; Caldwell, Charles C 2018. Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. Shock (Augusta, Ga.), ,

Bao, Junxiang; Li, Guangbi; Yuan, Xinxu; Li, Pin-Lan; Gulbins, Erich 2017. Contribution of p62 to Phenotype Transition of Coronary Arterial Myocytes with Defective Autophagy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 41 2, 555-568

Bao, Jun-Xiang; Zhang, Qin-Fang; Wang, Mi; Xia, Min; Boini, Krishna M; Gulbins, Erich; Zhang, Yang; Li, Pin-Lan 2017. Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary arterial myocytes. Frontiers in bioscience (Landmark edition), 22 , 558-569

Becker, Katrin Anne; Beckmann, Nadine; Adams, Constantin; Hessler, Gabriele; Kramer, Melanie; Gulbins, Erich; Carpinteiro, Alexander 2017. Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets. Clinical & experimental metastasis, 34 1, 25-35

Becker, Katrin Anne; Halmer, Ramona; Davies, Laura; Henry, Brian D; Ziobro-Henry, Regan; Decker, Yann; Liu, Yang; Gulbins, Erich; Fassbender, Klaus; Walter, Silke 2017. Blockade of Experimental Multiple Sclerosis by Inhibition of the Acid Sphingomyelinase/Ceramide System. Neuro-Signals, 25 1, 88-97

Becker, Katrin Anne; Li, Xiang; Seitz, Aaron; Steinmann, Joerg; Koch, Anne; Schuchman, Edward; Kamler, Markus; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich 2017. Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43 4, 1603-1616

Beckmann, Nadine; Becker, Katrin Anne; Walter, Silke; Becker, Jan U; Kramer, Melanie; Hessler, Gabriele; Weber, Stefanie; Göthert, Joachim R; Fassbender, Klaus; Gulbins, Erich; Carpinteiro, Alexander 2017. Regulation of Arthritis Severity by the Acid Sphingomyelinase. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43 4, 1460-1471

Chami, Marwan; Halmer, Ramona; Schnoeder, Laura; Anne Becker, Katrin; Meier, Carola; Fassbender, Klaus; Gulbins, Erich; Walter, Silke 2017. Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination. PloS one, 12 6, e0178622

Fayyaz, Susann; Japtok, Lukasz; Schumacher, Fabian; Wigger, Dominik; Schulz, Tim Julius; Haubold, Kathrin; Gulbins, Erich; Völler, Heinz; Kleuser, Burkhard 2017. Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43 2, 445-456

Folkesson, Maggie; Vorkapic, Emina; Gulbins, Erich; Japtok, Lukasz; Kleuser, Burkhard; Welander, Martin; Länne, Toste; Wågsäter, Dick 2017. Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms. Journal of vascular surgery, 65 4, 1171-1179.e1

Grassmé, Heike; Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Riethmüller, Joachim; Gardner, Aaron; Seitz, Aaron P; Steinmann, Joerg; Lang, Stephan; Ward, Christopher; Schuchman, Edward H; Caldwell, Charles C; Kamler, Markus; Edwards, Michael J; Brodlie, Malcolm; Gulbins, Erich 2017. ?1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections. Cell host & microbe, 21 6, 707-718.e8

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A 2017. Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation. Annals of surgery, 265 1, 218-226

Item, Flurin; Wueest, Stephan; Lemos, Vera; Stein, Sokrates; Lucchini, Fabrizio C; Denzler, Rémy; Fisser, Muriel C; Challa, Tenagne D; Pirinen, Eija; Kim, Youngsoo; Hemmi, Silvio; Gulbins, Erich; Gross, Atan; O'Reilly, Lorraine A; Stoffel, Markus; Auwerx, Johan; Konrad, Daniel 2017. Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function. Nature communications, 8 1, 480

Kovacic, Barbara; Sehl, Carolin; Wilker, Barbara; Kamler, Markus; Gulbins, Erich; Becker, Katrin Anne 2017. Glucosylceramide Critically Contributes to the Host Defense of Cystic Fibrosis Lungs. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 41 3, 1208-1218

Leanza, Luigi; Romio, Matteo; Becker, Katrin Anne; Azzolini, Michele; Trentin, Livio; Managò, Antonella; Venturini, Elisa; Zaccagnino, Angela; Mattarei, Andrea; Carraretto, Luca; Urbani, Andrea; Kadow, Stephanie; Biasutto, Lucia; Martini, Veronica; Severin, Filippo; Peruzzo, Roberta; Trimarco, Valentina; Egberts, Jan-Hendrik; Hauser, Charlotte; Visentin, Andrea; Semenzato, Gianpietro; Kalthoff, Holger; Zoratti, Mario; Gulbins, Erich; Paradisi, Cristina; Szabo, Ildiko 2017. Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo. Cancer cell, 31 4, 516-531.e10

Li, Cao; Wu, Yuqing; Riehle, Andrea; Ma, Jie; Kamler, Markus; Gulbins, Erich; Grassmé, Heike 2017. Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia. Infection and immunity, 85 5,

Li, Cao; Wu, Yuqing; Riehle, Andrea; Orian-Rousseau, Véronique; Zhang, Yang; Gulbins, Erich; Grassmé, Heike 2017. Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase. Antioxidants & redox signaling, ,

Ma, Jie; Gulbins, Erich; Edwards, Michael J; Caldwell, Charles C; Fraunholz, Martin; Becker, Katrin Anne 2017. Staphylococcus aureus ?-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43 6, 2170-2184

Martin, Grace E; Boudreau, Ryan M; Couch, Caroline; Becker, Katrin Anne; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Seitz, Aaron 2017. Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic. Biochimie, 141 , 91-96

Müller, Christian P; Kalinichenko, Liubov S; Tiesel, Jens; Witt, Matthias; Stöckl, Thomas; Sprenger, Eva; Fuchser, Jens; Beckmann, Janine; Praetner, Marc; Huber, Sabine E; Amato, Davide; Mühle, Christiane; Büttner, Christian; Ekici, Arif B; Smaga, Irena; Pomierny-Chamiolo, Lucyna; Pomierny, Bartosz; Filip, Malgorzata; Eulenburg, Volker; Gulbins, Erich; Lourdusamy, Anbarasu; Reichel, Martin; Kornhuber, Johannes 2017. Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis. Acta neuropathologica, 133 3, 463-483

Rhein, Cosima; Reichel, Martin; Kramer, Marcel; Rotter, Andrea; Lenz, Bernd; Mühle, Christiane; Gulbins, Erich; Kornhuber, Johannes 2017. Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression. Journal of affective disorders, 209 , 10-15

Rice, Teresa C; Armocida, Stephanie M; Kuethe, Joshua W; Midura, Emily F; Jain, Ayushi; Hildeman, David A; Healy, Daniel P; Gulbins, Erich; Caldwell, Charles C 2017. Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner. Cellular immunology, 313 , 25-31

Rice, Teresa C; Pugh, Amanda M; Seitz, Aaron P; Gulbins, Erich; Nomellini, Vanessa; Caldwell, Charles C 2017. Sphingosine rescues aged mice from pulmonary pseudomonas infection. The Journal of surgical research, 219 , 354-359

Rice, Teresa C; Pugh, Amanda M; Xia, Brent T; Seitz, Aaron P; Whitacre, Brynne E; Gulbins, Erich; Caldwell, Charles C 2017. Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection. Journal of the American College of Surgeons, 225 4, 538-547

Schneider, Miriam; Levant, Beth; Reichel, Martin; Gulbins, Erich; Kornhuber, Johannes; Müller, Christian P 2017. Lipids in psychiatric disorders and preventive medicine. Neuroscience and biobehavioral reviews, 76 Pt B, 336-362

Schumacher, Fabian; Neuber, Corinna; Finke, Hannah; Nieschalke, Kai; Baesler, Jessica; Gulbins, Erich; Kleuser, Burkhard 2017. The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. Journal of lipid research, 58 8, 1648-1660

Sydor, Svenja; Sowa, Jan-Peter; Megger, Dominik A; Schlattjan, Martin; Jafoui, Sami; Wingerter, Lena; Carpinteiro, Alexander; Baba, Hideo A; Bechmann, Lars P; Sitek, Barbara; Gerken, Guido; Gulbins, Erich; Canbay, Ali 2017. Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis. Molecular metabolism, 6 5, 416-427

Venturini, Elisa; Leanza, Luigi; Azzolini, Michele; Kadow, Stephanie; Mattarei, Andrea; Weller, Michael; Tabatabai, Ghazaleh; Edwards, Michael J; Zoratti, Mario; Paradisi, Cristina; Szabò, Ildikò; Gulbins, Erich; Becker, Katrin Anne 2017. Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells. Neuro-Signals, 25 1, 26-38

Wu, Yuqing; Gulbins, Erich; Grassmé, Heike 2017. Crosstalk Between Sphingomyelinases and Reactive Oxygen Species in Mycobacterial Infection. Antioxidants & redox signaling, ,

Adams, Constantin; Icheva, Vanya; Deppisch, Caroline; Lauer, Josefine; Herrmann, Gloria; Graepler-Mainka, Ute; Heyder, Susanne; Gulbins, Erich; Riethmueller, Joachim 2016. Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39 2, 565-72

Carpinteiro, Alexander; Beckmann, Nadine; Seitz, Aaron; Hessler, Gabriele; Wilker, Barbara; Soddemann, Matthias; Helfrich, Iris; Edelmann, Bärbel; Gulbins, Erich; Becker, Katrin Anne 2016. Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 38 1, 1-14

Gulbins, Anne; Grassmé, Heike; Hoehn, Richard; Kohnen, Marcus; Edwards, Michael J; Kornhuber, Johannes; Gulbins, Erich 2016. Role of Janus-Kinases in Major Depressive Disorder. Neuro-Signals, 24 1, 71-80

Gulbins, Anne; Grassmé, Heike; Hoehn, Richard; Wilker, Barbara; Soddemann, Matthias; Kohnen, Marcus; Edwards, Michael J; Kornhuber, Johannes; Gulbins, Erich 2016. Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial Ceramide. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39 2, 790-801

Hoehn, Richard S; Jernigan, Peter L; Chang, Alex L; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Pritts, Timothy A 2016. Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39 1, 331-40

Hoehn, Richard S; Seitz, Aaron P; Jernigan, Peter L; Gulbins, Erich; Edwards, Michael J 2016. Ischemia/Reperfusion Injury Alters Sphingolipid Metabolism in the Gut. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39 4, 1262-70

Hoehn, Richard; Monse, Marlene; Pohl, Ella; Wranik, Sina; Wilker, Barbara; Keitsch, Simone; Soddemann, Matthias; Kornhuber, Johannes; Kohnen, Marcus; Edwards, Michael J; Grassmé, Heike; Gulbins, Erich 2016. Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System. Neuro-Signals, 24 1, 48-58

Hollmann, Claudia; Werner, Sandra; Avota, Elita; Reuter, Dajana; Japtok, Lukasz; Kleuser, Burkhard; Gulbins, Erich; Becker, Katrin Anne; Schneider-Schaulies, Jürgen; Beyersdorf, Niklas 2016. Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells. Journal of immunology (Baltimore, Md. : 1950), 197 8, 3130-3141

Huston, Joseph P; Kornhuber, Johannes; Mühle, Christiane; Japtok, Lukasz; Komorowski, Mara; Mattern, Claudia; Reichel, Martin; Gulbins, Erich; Kleuser, Burkhard; Topic, Bianca; De Souza Silva, Maria A; Müller, Christian P 2016. A sphingolipid mechanism for behavioral extinction. Journal of neurochemistry, 137 4, 589-603

Johnson, Bobby L; Rice, Teresa C; Xia, Brent T; Boone, Kirsten I; Green, Ellis A; Gulbins, Erich; Caldwell, Charles C 2016. Amitriptyline Usage Exacerbates the Immune Suppression Following Burn Injury. Shock (Augusta, Ga.), 46 5, 541-548

Leanza, Luigi; Managò, Antonella; Zoratti, Mario; Gulbins, Erich; Szabo, Ildiko 2016. Pharmacological targeting of ion channels for cancer therapy: In vivo evidences. Biochimica et biophysica acta, 1863 6 Pt B, 1385-97

Li, Cao; Peng, Huiming; Japtok, Lukasz; Seitz, Aaron; Riehle, Andrea; Wilker, Barbara; Soddemann, Matthias; Kleuser, Burkard; Edwards, Michael; Lammas, David; Zhang, Yang; Gulbins, Erich; Grassme, Heike 2016. Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosis. Frontiers in bioscience (Elite edition), 8 , 311-25

Makdessi, Samar Al; Sweidan, Hicham; Schmid, Evi; Weimar, Udo; Gulbins, Erich; Lang, Florian 2016. Quantitative Determination of Ceramide Molecular Species in Dendritic Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39 4, 1608-17

Nojima, Hiroyuki; Freeman, Christopher M; Schuster, Rebecca M; Japtok, Lukasz; Kleuser, Burkhard; Edwards, Michael J; Gulbins, Erich; Lentsch, Alex B 2016. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. Journal of hepatology, 64 1, 60-8

Nojima, Hiroyuki; Konishi, Takanori; Freeman, Christopher M; Schuster, Rebecca M; Japtok, Lukasz; Kleuser, Burkhard; Edwards, Michael J; Gulbins, Erich; Lentsch, Alex B 2016. Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. PloS one, 11 8, e0161443

Rice, Teresa C; Seitz, Aaron P; Edwards, Michael J; Gulbins, Erich; Caldwell, Charles C 2016. Frontline Science: Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection. Journal of leukocyte biology, 100 6, 1233-1237

Tavakoli Tabazavareh, Shaghayegh; Seitz, Aaron; Jernigan, Peter; Sehl, Carolin; Keitsch, Simone; Lang, Stephan; Kahl, Barbara C; Edwards, Michael; Grassmé, Heike; Gulbins, Erich; Becker, Katrin Anne 2016. Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic Fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 38 6, 2094-102

Wang, Lei; Chen, Yang; Li, Xiang; Zhang, Youzhi; Gulbins, Erich; Zhang, Yang 2016. Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation. Oncotarget, 7 45, 73229-73241

Zhou, Yuetao; Salker, Madhuri S; Walker, Britta; Münzer, Patrick; Borst, Oliver; Gawaz, Meinrad; Gulbins, Erich; Singh, Yogesh; Lang, Florian 2016. Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39 3, 985-95

Zoicas, Iulia; Reichel, Martin; Gulbins, Erich; Kornhuber, Johannes 2016. Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory. PloS one, 11 9, e0162498

Carpinteiro, Alexander; Becker, Katrin Anne; Japtok, Lukasz; Hessler, Gabriele; Keitsch, Simone; Požgajovà, Miroslava; Schmid, Kurt W; Adams, Constantin; Müller, Stefan; Kleuser, Burkhard; Edwards, Michael J; Grassmé, Heike; Helfrich, Iris; Gulbins, Erich 2015. Regulation of hematogenous tumor metastasis by acid sphingomyelinase. EMBO molecular medicine, 7 6, 714-34

Chen, Yang; Li, Xiang; Boini, Krishna M; Pitzer, Ashley L; Gulbins, Erich; Zhang, Yang; Li, Pin-Lan 2015. Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis. Biochimica et biophysica acta, 1853 2, 396-408

Grassmé, Heike; Jernigan, Peter L; Hoehn, Richard S; Wilker, Barbara; Soddemann, Matthias; Edwards, Michael J; Müller, Christian P; Kornhuber, Johannes; Gulbins, Erich 2015. Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression. Neuro-Signals, 23 1, 84-92

Gulbins, Erich 2015. Highlight: molecular medicine of sphingolipids. Biological chemistry, 396 6-7, 569-71

Gulbins, Erich; Walter, Silke; Becker, Katrin Anne; Halmer, Ramona; Liu, Yang; Reichel, Martin; Edwards, Michael J; Müller, Christian P; Fassbender, Klaus; Kornhuber, Johannes 2015. A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression. Journal of neurochemistry, 134 2, 183-92

Henry, Brian D; Neill, Daniel R; Becker, Katrin Anne; Gore, Suzanna; Bricio-Moreno, Laura; Ziobro, Regan; Edwards, Michael J; Mühlemann, Kathrin; Steinmann, Jörg; Kleuser, Burkhard; Japtok, Lukasz; Luginbühl, Miriam; Wolfmeier, Heidi; Scherag, André; Gulbins, Erich; Kadioglu, Aras; Draeger, Annette; Babiychuk, Eduard B 2015. Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice. Nature biotechnology, 33 1, 81-8

Hilker, Rolf; Munder, Antje; Klockgether, Jens; Losada, Patricia Moran; Chouvarine, Philippe; Cramer, Nina; Davenport, Colin F; Dethlefsen, Sarah; Fischer, Sebastian; Peng, Huiming; Schönfelder, Torben; Türk, Oliver; Wiehlmann, Lutz; Wölbeling, Florian; Gulbins, Erich; Goesmann, Alexander; Tümmler, Burkhard 2015. Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment. Environmental microbiology, 17 1, 29-46

Jernigan, Peter L; Hoehn, Richard S; Grassmé, Heike; Edwards, Michael J; Müller, Christian P; Kornhuber, Johannes; Gulbins, Erich 2015. Sphingolipids in Major Depression. Neuro-Signals, 23 1, 49-58

Lang, Elisabeth; Bissinger, Rosi; Gulbins, Erich; Lang, Florian 2015. Ceramide in the regulation of eryptosis, the suicidal erythrocyte death. Apoptosis : an international journal on programmed cell death, 20 5, 758-67

Lang, Elisabeth; Gatidis, Sergios; Freise, Noemi F; Bock, Hans; Kubitz, Ralf; Lauermann, Christian; Orth, Hans Martin; Klindt, Caroline; Schuier, Maximilian; Keitel, Verena; Reich, Maria; Liu, Guilai; Schmidt, Sebastian; Xu, Haifeng C; Qadri, Syed M; Herebian, Diran; Pandyra, Aleksandra A; Mayatepek, Ertan; Gulbins, Erich; Lang, Florian; Häussinger, Dieter; Lang, Karl S; Föller, Michael; Lang, Philipp A 2015. Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology (Baltimore, Md.), 61 1, 275-84

Leanza, Luigi; Venturini, Elisa; Kadow, Stephanie; Carpinteiro, Alexander; Gulbins, Erich; Becker, Katrin Anne 2015. Targeting a mitochondrial potassium channel to fight cancer. Cell calcium, 58 1, 131-138

Lee, Hyunmi; Rotolo, Jimmy A; Mesicek, Judith; Penate-Medina, Tuula; Rimner, Andreas; Liao, Wen-Chieh; Yin, Xianglei; Ragupathi, Govind; Ehleiter, Desiree; Gulbins, Erich; Zhai, Dayong; Reed, John C; Haimovitz-Friedman, Adriana; Fuks, Zvi; Kolesnick, Richard 2015. Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation. PloS one, 10 12, e0146210

Managò, Antonella; Becker, Katrin Anne; Carpinteiro, Alexander; Wilker, Barbara; Soddemann, Matthias; Seitz, Aaron P; Edwards, Michael J; Grassmé, Heike; Szabò, Ildiko; Gulbins, Erich 2015. Pseudomonas aeruginosa pyocyanin induces neutrophil death via mitochondrial reactive oxygen species and mitochondrial acid sphingomyelinase. Antioxidants & redox signaling, 22 13, 1097-110

Merches, Katja; Khairnar, Vishal; Knuschke, Torben; Shaabani, Namir; Honke, Nadine; Duhan, Vikas; Recher, Mike; Navarini, Alexander A; Hardt, Cornelia; Häussinger, Dieter; Tümmler, Burkhard; Gulbins, Erich; Futerman, Anthony H; Hoffmann, Daniel; Lang, Florian; Lang, Philipp A; Westendorf, Astrid M; Lang, Karl S 2015. Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36 6, 2379-92

Müller, Christian P; Reichel, Martin; Mühle, Christiane; Rhein, Cosima; Gulbins, Erich; Kornhuber, Johannes 2015. Brain membrane lipids in major depression and anxiety disorders. Biochimica et biophysica acta, 1851 8, 1052-1065

Nojima, Hiroyuki; Freeman, Christopher M; Gulbins, Erich; Lentsch, Alex B 2015. Sphingolipids in liver injury, repair and regeneration. Biological chemistry, 396 6-7, 633-43

Peng, Huiming; Li, Cao; Kadow, Stephanie; Henry, Brian D; Steinmann, Jörg; Becker, Katrin Anne; Riehle, Andrea; Beckmann, Natalie; Wilker, Barbara; Li, Pin-Lan; Pritts, Timothy; Edwards, Michael J; Zhang, Yang; Gulbins, Erich; Grassmé, Heike 2015. Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis. Journal of molecular medicine (Berlin, Germany), 93 6, 675-89

Quillin, Ralph C; Wilson, Gregory C; Nojima, Hiroyuki; Freeman, Christopher M; Wang, Jiang; Schuster, Rebecca M; Blanchard, John A; Edwards, Michael J; Gandhi, Chandrashekhar R; Gulbins, Erich; Lentsch, Alex B 2015. Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice. Hepatology research : the official journal of the Japan Society of Hepatology, 45 3, 305-14

Reichel, Martin; Hönig, Stefanie; Liebisch, Gerhard; Lüth, Anja; Kleuser, Burkhard; Gulbins, Erich; Schmitz, Gerd; Kornhuber, Johannes 2015. Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. Biochimica et biophysica acta, 1851 11, 1501-10

Schumacher, Fabian; Chakraborty, Sudipta; Kleuser, Burkhard; Gulbins, Erich; Schwerdtle, Tanja; Aschner, Michael; Bornhorst, Julia 2015. Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans. Talanta, 144 , 71-9

Seitz, Aaron P; Grassmé, Heike; Edwards, Michael J; Pewzner-Jung, Yael; Gulbins, Erich 2015. Ceramide and sphingosine in pulmonary infections. Biological chemistry, 396 6-7, 611-20

Beckmann, Nadine; Sharma, Deepa; Gulbins, Erich; Becker, Katrin Anne; Edelmann, Bärbel 2014. Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons. Frontiers in physiology, 5 , 331

Brown, Mary Beth; Hunt, William R; Noe, Julie E; Rush, Natalia I; Schweitzer, Kelly S; Leece, Thomas C; Moldobaeva, Aigul; Wagner, Elizabeth M; Dudek, Steven M; Poirier, Christophe; Presson, Robert G; Gulbins, Erich; Petrache, Irina 2014. Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smoke. Pulmonary circulation, 4 2, 260-8

Grassmé, Heike; Carpinteiro, Alexander; Edwards, Michael J; Gulbins, Erich; Becker, Katrin Anne 2014. Regulation of the inflammasome by ceramide in cystic fibrosis lungs. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34 1, 45-55

Kornhuber, Johannes; Müller, Christian P; Becker, Katrin Anne; Reichel, Martin; Gulbins, Erich 2014. The ceramide system as a novel antidepressant target. Trends in pharmacological sciences, 35 6, 293-304

Li, Xiang; Zhang, Yang; Xia, Min; Gulbins, Erich; Boini, Krishna M; Li, Pin-Lan 2014. Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. PloS one, 9 1, e87552

Mühle, Christiane; Amova, Violina; Biermann, Teresa; Bayerlein, Kristina; Richter-Schmidinger, Tanja; Kraus, Thomas; Reichel, Martin; Gulbins, Erich; Kornhuber, Johannes 2014. Sex-dependent decrease of sphingomyelinase activity during alcohol withdrawal treatment. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34 1, 71-81

Münzer, Patrick; Borst, Oliver; Walker, Britta; Schmid, Evi; Feijge, Marion A H; Cosemans, Judith M E M; Chatterjee, Madhumita; Schmidt, Eva-Maria; Schmidt, Sebastian; Towhid, Syeda T; Leibrock, Christina; Elvers, Margitta; Schaller, Martin; Seizer, Peter; Ferlinz, Klaus; May, Andreas E; Gulbins, Erich; Heemskerk, Johan W M; Gawaz, Meinrad; Lang, Florian 2014. Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation. Arteriosclerosis, thrombosis, and vascular biology, 34 1, 61-71

Neuber, Corinna; Schumacher, Fabian; Gulbins, Erich; Kleuser, Burkhard 2014. Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. Analytical chemistry, 86 18, 9065-73

Pewzner-Jung, Yael; Tavakoli Tabazavareh, Shaghayegh; Grassmé, Heike; Becker, Katrin Anne; Japtok, Lukasz; Steinmann, Jörg; Joseph, Tammar; Lang, Stephan; Tuemmler, Burkhard; Schuchman, Edward H; Lentsch, Alex B; Kleuser, Burkhard; Edwards, Michael J; Futerman, Anthony H; Gulbins, Erich 2014. Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa. EMBO molecular medicine, 6 9, 1205-14

Reichel, Martin; Richter-Schmidinger, Tanja; Mühle, Christiane; Rhein, Cosima; Alexopoulos, Panagiotis; Schwab, Sibylle G; Gulbins, Erich; Kornhuber, Johannes 2014. The common acid sphingomyelinase polymorphism p.G508R is associated with self-reported allergy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34 1, 82-91

Siegmann, Nanna; Worbs, David; Effinger, Frauke; Bormann, Tobias; Gebhardt, Madlen; Ulrich, Martina; Wermeling, Fredrik; Müller-Hermelink, Eva; Biedermann, Tilo; Tighe, Mike; Edwards, Michael J; Caldwell, Charles; Leadbetter, Elizabeth; Karlsson, Mikael C I; Becker, Katrin Anne; Gulbins, Erich; Döring, Gerd 2014. Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34 1, 56-70

Simonis, Alexander; Hebling, Sabrina; Gulbins, Erich; Schneider-Schaulies, Sibylle; Schubert-Unkmeir, Alexandra 2014. Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cells. PLoS pathogens, 10 6, e1004160

Vidigal, Pedrina G; Müsken, Mathias; Becker, Katrin A; Häussler, Susanne; Wingender, Jost; Steinmann, Eike; Kehrmann, Jan; Gulbins, Erich; Buer, Jan; Rath, Peter Michael; Steinmann, Jörg 2014. Effects of green tea compound epigallocatechin-3-gallate against Stenotrophomonas maltophilia infection and biofilm. PloS one, 9 4, e92876

Zhang, Yang; Xu, Ming; Xia, Min; Li, Xiang; Boini, Krishna M; Wang, Mi; Gulbins, Erich; Ratz, Paul H; Li, Pin-Lan 2014. Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. Cardiovascular research, 102 1, 68-78

Abed, Majed; Towhid, Syeda T; Pakladok, Tatsiana; Alesutan, Ioana; Götz, Friedrich; Gulbins, Erich; Lang, Florian 2013. Effect of bacterial peptidoglycan on erythrocyte death and adhesion to endothelial cells. International journal of medical microbiology : IJMM, 303 4, 182-9

Gramatzki, Dorothee; Herrmann, Caroline; Happold, Caroline; Becker, Katrin Anne; Gulbins, Erich; Weller, Michael; Tabatabai, Ghazaleh 2013. Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PloS one, 8 5, e63527

Grassmé, Heike; Riethmüller, Joachim; Gulbins, Erich 2013. Ceramide in cystic fibrosis. Handbook of experimental pharmacology, 216, 265-74

Gulbins, Erich; Kolesnick, Richard N 2013. It takes a CAD to kill a tumor cell with a LMP. Cancer cell, 24 3, 279-81

Gulbins, Erich; Palmada, Monica; Reichel, Martin; Lüth, Anja; Böhmer, Christoph; Amato, Davide; Müller, Christian P; Tischbirek, Carsten H; Groemer, Teja W; Tabatabai, Ghazaleh; Becker, Katrin A; Tripal, Philipp; Staedtler, Sven; Ackermann, Teresa F; van Brederode, Johannes; Alzheimer, Christian; Weller, Michael; Lang, Undine E; Kleuser, Burkhard; Grassmé, Heike; Kornhuber, Johannes 2013. Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nature medicine, 19 7, 934-8

Henry, Brian; Möller, Christina; Dimanche-Boitrel, Marie-Therese; Gulbins, Erich; Becker, Katrin Anne 2013. Targeting the ceramide system in cancer. Cancer letters, 332 2, 286-94

Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Kolesnick, Richard; Gulbins, Erich 2013. Acid sphingomyelinase. Handbook of experimental pharmacology, 215, 77-88

Kornhuber, Johannes; Tripal, Philipp; Gulbins, Erich; Muehlbacher, Markus 2013. Functional inhibitors of acid sphingomyelinase (FIASMAs). Handbook of experimental pharmacology, 215, 169-86

Leanza, Luigi; Biasutto, Lucia; Managò, Antonella; Gulbins, Erich; Zoratti, Mario; Szabò, Ildikò 2013. Intracellular ion channels and cancer. Frontiers in physiology, 4 , 227

Mühle, Christiane; Huttner, Hagen B; Walter, Silke; Reichel, Martin; Canneva, Fabio; Lewczuk, Piotr; Gulbins, Erich; Kornhuber, Johannes 2013. Characterization of acid sphingomyelinase activity in human cerebrospinal fluid. PloS one, 8 5, e62912

Nährlich, Lutz; Mainz, Jochen G; Adams, Constantin; Engel, Corinna; Herrmann, Gloria; Icheva, Vanya; Lauer, Josefine; Deppisch, Caroline; Wirth, Andreas; Unger, Katy; Graepler-Mainka, Ute; Hector, Andreas; Heyder, Susanne; Stern, Martin; Döring, Gerd; Gulbins, Erich; Riethmüller, Joachim 2013. Therapy of CF-patients with amitriptyline and placebo--a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 31 4-5, 505-12

Xu, Ming; Li, Xiao-Xue; Xiong, Jing; Xia, Min; Gulbins, Erich; Zhang, Yang; Li, Pin-Lan 2013. Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. Biochimica et biophysica acta, 1833 12, 3228-36

Ziobro, Regan; Henry, Brian; Edwards, Michael J; Lentsch, Alex B; Gulbins, Erich 2013. Ceramide mediates lung fibrosis in cystic fibrosis. Biochemical and biophysical research communications, 434 4, 705-9

Abed, Majed; Towhid, Syeda T; Mia, Sobuj; Pakladok, Tatsiana; Alesutan, Ioana; Borst, Oliver; Gawaz, Meinrad; Gulbins, Erich; Lang, Florian 2012. Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells. American journal of physiology. Cell physiology, 303 9, C991-9

Becker, Katrin Anne; Henry, Brian; Ziobro, Regan; Tümmler, Burkhard; Gulbins, Erich; Grassmé, Heike 2012. Role of CD95 in pulmonary inflammation and infection in cystic fibrosis. Journal of molecular medicine (Berlin, Germany), 90 9, 1011-23

Leanza, Luigi; Henry, Brian; Sassi, Nicola; Zoratti, Mario; Chandy, K George; Gulbins, Erich; Szabò, Ildikò 2012. Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO molecular medicine, 4 7, 577-93

Li, Xiang; Gulbins, Erich; Zhang, Yang 2012. Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injury. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30 4, 905-14

Li, Xiang; Gulbins, Erich; Zhang, Yang 2012. Oxidative stress triggers Ca-dependent lysosome trafficking and activation of acid sphingomyelinase. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30 4, 815-26

Rhein, Cosima; Tripal, Philipp; Seebahn, Angela; Konrad, Alice; Kramer, Marcel; Nagel, Christine; Kemper, Jonas; Bode, Jens; Mühle, Christiane; Gulbins, Erich; Reichel, Martin; Becker, Cord-Michael; Kornhuber, Johannes 2012. Functional implications of novel human acid sphingomyelinase splice variants. PloS one, 7 4, e35467

Szabò, Ildikò; Leanza, Luigi; Gulbins, Erich; Zoratti, Mario 2012. Physiology of potassium channels in the inner membrane of mitochondria. Pflügers Archiv : European journal of physiology, 463 2, 231-46

Avota, Elita; Gulbins, Erich; Schneider-Schaulies, Sibylle 2011. DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells. PLoS pathogens, 7 2, e1001290

Becker, Katrin Anne; Henry, Brian; Ziobro, Regan; Riethmüller, Joachim; Gulbins, Erich 2011. Lipids in cystic fibrosis. Expert review of respiratory medicine, 5 4, 527-35

Cheng, Yu; Gulbins, Erich; Siemen, Detlef 2011. Activation of the permeability transition pore by Bax via inhibition of the mitochondrial BK channel. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 27 3-4, 191-200

Dimanche-Boitrel, Marie-Thérèse; Rebillard, Amélie; Gulbins, Erich 2011. Ceramide in chemotherapy of tumors. Recent patents on anti-cancer drug discovery, 6 3, 284-93

Kornhuber, Johannes; Muehlbacher, Markus; Trapp, Stefan; Pechmann, Stefanie; Friedl, Astrid; Reichel, Martin; Mühle, Christiane; Terfloth, Lothar; Groemer, Teja W; Spitzer, Gudrun M; Liedl, Klaus R; Gulbins, Erich; Tripal, Philipp 2011. Identification of novel functional inhibitors of acid sphingomyelinase. PloS one, 6 8, e23852

Lang, Florian; Ullrich, Susanne; Gulbins, Erich 2011. Ceramide formation as a target in beta-cell survival and function. Expert opinion on therapeutic targets, 15 9, 1061-71

Lee, Hyunmi; Rotolo, Jimmy A; Mesicek, Judith; Penate-Medina, Tuula; Rimner, Andreas; Liao, Wen-Chieh; Yin, Xianglei; Ragupathi, Govind; Ehleiter, Desiree; Gulbins, Erich; Zhai, Dayong; Reed, John C; Haimovitz-Friedman, Adriana; Fuks, Zvi; Kolesnick, Richard 2011. Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PloS one, 6 6, e19783

Meyer zu Hörste, Melissa; Ströher, Elena; Berchner-Pfannschmidt, Utta; Schmitz-Spanke, Simone; Pink, Mario; Göthert, Joachim R; Fischer, Jens W; Gulbins, Erich; Eckstein, Anja K 2011. A novel mechanism involved in the pathogenesis of Graves ophthalmopathy (GO): clathrin is a possible targeting molecule for inhibiting local immune response in the orbit. The Journal of clinical endocrinology and metabolism, 96 11, E1727-36

Munder, Antje; Wölbeling, Florian; Kerber-Momot, Tanja; Wedekind, Dirk; Baumann, Ulrich; Gulbins, Erich; Tümmler, Burkhard 2011. Acute intratracheal Pseudomonas aeruginosa infection in cystic fibrosis mice is age-independent. Respiratory research, 12 , 148

Reichel, Martin; Beck, Johannes; Mühle, Christiane; Rotter, Andrea; Bleich, Stefan; Gulbins, Erich; Kornhuber, Johannes 2011. Activity of secretory sphingomyelinase is increased in plasma of alcohol-dependent patients. Alcoholism, clinical and experimental research, 35 10, 1852-9

Zhang, Yang; Li, Xiang; Carpinteiro, Alexander; Goettel, Jeremy A; Soddemann, Matthias; Gulbins, Erich 2011. Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections. Nature medicine, 17 3, 341-6

Becker, Katrin Anne; Grassmé, Heike; Zhang, Yang; Gulbins, Erich 2010. Ceramide in Pseudomonas aeruginosa infections and cystic fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 26 1, 57-66

Becker, Katrin Anne; Riethmüller, Joachim; Lüth, Anja; Döring, Gerd; Kleuser, Burkhard; Gulbins, Erich 2010. Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis. American journal of respiratory cell and molecular biology, 42 6, 716-24

Becker, Katrin Anne; Riethmüller, Joachim; Zhang, Yang; Gulbins, Erich 2010. The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis. The open respiratory medicine journal, 4 , 39-47

Becker, Katrin Anne; Tümmler, Burkhard; Gulbins, Erich; Grassmé, Heike 2010. Accumulation of ceramide in the trachea and intestine of cystic fibrosis mice causes inflammation and cell death. Biochemical and biophysical research communications, 403 3-4, 368-74

Grassmé, Heike; Becker, Katrin Anne; Zhang, Yang; Gulbins, Erich 2010. CFTR-dependent susceptibility of the cystic fibrosis-host to Pseudomonas aeruginosa. International journal of medical microbiology : IJMM, 300 8, 578-83

Gulbins, Erich 2010. Lipids control mucus production in cystic fibrosis. Nature medicine, 16 3, 267-8

Kornhuber, Johannes; Tripal, Philipp; Reichel, Martin; Mühle, Christiane; Rhein, Cosima; Muehlbacher, Markus; Groemer, Teja W; Gulbins, Erich 2010. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 26 1, 9-20

Lang, Elisabeth; Lang, Philipp A; Shumilina, Ekaterina; Qadri, Syed M; Kucherenko, Yuliya; Kempe, Daniela S; Föller, Michael; Capasso, Anna; Wieder, Thomas; Gulbins, Erich; Clemen, Christoph S; Herr, Claudia; Noegel, Angelika A; Huber, Stephan M; Lang, Florian 2010. Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7. Pflügers Archiv : European journal of physiology, 460 3, 667-76

Lang, Florian; Gulbins, Erich; Lang, Philipp A; Zappulla, Donatella; Föller, Michael 2010. Ceramide in suicidal death of erythrocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 26 1, 21-8

Perrotta, Cristiana; Bizzozero, Laura; Cazzato, Denise; Morlacchi, Sara; Assi, Emma; Simbari, Fabio; Zhang, Yang; Gulbins, Erich; Bassi, Maria Teresa; Rosa, Patrizia; Clementi, Emilio 2010. Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function. The Journal of biological chemistry, 285 51, 40240-51

Reichel, Martin; Greiner, Elisabeth; Richter-Schmidinger, Tanja; Yedibela, Ozlem; Tripal, Philipp; Jacobi, Andrea; Bleich, Stefan; Gulbins, Erich; Kornhuber, Johannes 2010. Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence. Alcoholism, clinical and experimental research, 34 1, 46-50

Szabò, Ildikò; Zoratti, Mario; Gulbins, Erich 2010. Contribution of voltage-gated potassium channels to the regulation of apoptosis. FEBS letters, 584 10, 2049-56

Ulrich, Martina; Worlitzsch, Dieter; Viglio, Simona; Siegmann, Nanna; Iadarola, Paolo; Shute, Janis K; Geiser, Marianne; Pier, Gerald B; Friedel, Godehard; Barr, Mark L; Schuster, Antje; Meyer, Keith C; Ratjen, Felix; Bjarnsholt, Thomas; Gulbins, Erich; Döring, Gerd 2010. Alveolar inflammation in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 9 3, 217-27

Verdurmen, Wouter P R; Thanos, Melissa; Ruttekolk, Ivo R; Gulbins, Erich; Brock, Roland 2010. Cationic cell-penetrating peptides induce ceramide formation via acid sphingomyelinase: implications for uptake. Journal of controlled release : official journal of the Controlled Release Society, 147 2, 171-9

Xuan, Nguyen Thi; Shumilina, Ekaterina; Gulbins, Erich; Gu, Shuchen; Götz, Friedrich; Lang, Florian 2010. Triggering of dendritic cell apoptosis by xanthohumol. Molecular nutrition & food research, 54 Suppl 2 , S214-24

Xuan, Nguyen Thi; Shumilina, Ekaterina; Kempe, Daniela S; Gulbins, Erich; Lang, Florian 2010. Sphingomyelinase dependent apoptosis of dendritic cells following treatment with amyloid peptides. Journal of neuroimmunology, 219 1-2, 81-9

Xuan, Nguyen Thi; Shumilina, Ekaterina; Schmid, Evi; Bhavsar, Shefalee K; Rexhepaj, Rexhep; Götz, Friedrich; Gulbins, Erich; Lang, Florian 2010. Role of acidic sphingomyelinase in thymol-mediated dendritic cell death. Molecular nutrition & food research, 54 12, 1833-41

Zhang, Yang; Li, Xiang; Grassmé, Heike; Döring, Gerd; Gulbins, Erich 2010. Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages on infection. Journal of immunology (Baltimore, Md. : 1950), 184 9, 5104-11

Banner, Katharine H; De Jonge, Hugo; Elborn, Stuart; Growcott, Ellena; Gulbins, Erich; Konstan, Mike; Moss, Rick; Poll, Chris; Randell, Scott H; Rossi, Adriano G; Thomas, Lorraine; Waltz, David 2009. Highlights of a workshop to discuss targeting inflammation in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 8 1, 1-8

Braun, Manuel; Föller, Michael; Gulbins, Erich; Lang, Florian 2009. Eryptosis triggered by bismuth. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 22 3, 453-60

Döring, Gerd; Gulbins, Erich 2009. Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease. Cellular microbiology, 11 2, 208-16

Dumitru, Claudia A; Sandalcioglu, Ibrahim E; Wagner, Marek; Weller, Michael; Gulbins, Erich 2009. Lysosomal ceramide mediates gemcitabine-induced death of glioma cells. Journal of molecular medicine (Berlin, Germany), 87 11, 1123-32

Dumitru, Claudia Alexandra; Weller, Michael; Gulbins, Erich 2009. Ceramide metabolism determines glioma cell resistance to chemotherapy. Journal of cellular physiology, 221 3, 688-95

Föller, Michael; Bobbala, Diwakar; Koka, Saisudha; Huber, Stephan M; Gulbins, Erich; Lang, Florian 2009. Suicide for survival--death of infected erythrocytes as a host mechanism to survive malaria. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 24 3-4, 133-40

Gassert, Evelyn; Avota, Elita; Harms, Harry; Krohne, Georg; Gulbins, Erich; Schneider-Schaulies, Sibylle 2009. Induction of membrane ceramides: a novel strategy to interfere with T lymphocyte cytoskeletal reorganisation in viral immunosuppression. PLoS pathogens, 5 10, e1000623

Kornhuber, Johannes; Reichel, Martin; Tripal, Philipp; Groemer, Teja W; Henkel, Andreas W; Mühle, Christiane; Gulbins, Erich 2009. The role of ceramide in major depressive disorder. European archives of psychiatry and clinical neuroscience, 259 Suppl 2 , S199-204

Lang, Philipp A; Kasinathan, Ravi S; Brand, Verena B; Duranton, Christophe; Lang, Camelia; Koka, Saisudha; Shumilina, Ekaterina; Kempe, Daniela S; Tanneur, Valerie; Akel, Ahmad; Lang, Karl S; Foller, Michael; Kun, Jurgen F J; Kremsner, Peter G; Wesselborg, Sebastian; Laufer, Stefan; Clemen, Christoph S; Herr, Claudia; Noegel, Angelika A; Wieder, Thomas; Gulbins, Erich; Lang, Florian; Huber, Stephan M 2009. Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 24 5-6, 415-28

Riethmüller, Joachim; Anthonysamy, Janina; Serra, Emilio; Schwab, Matthias; Döring, Gerd; Gulbins, Erich 2009. Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 24 1-2, 65-72

Zhang, Yang; Li, Xiang; Becker, Katrin Anne; Gulbins, Erich 2009. Ceramide-enriched membrane domains--structure and function. Biochimica et biophysica acta, 1788 1, 178-83

Zoratti, Mario; De Marchi, Umberto; Gulbins, Erich; Szabò, Ildikò 2009. Novel channels of the inner mitochondrial membrane. Biochimica et biophysica acta, 1787 5, 351-63

Carpinteiro, Alexander; Dumitru, Claudia; Schenck, Marcus; Gulbins, Erich 2008. Ceramide-induced cell death in malignant cells. Cancer letters, 264 1, 1-10

Gulbins, Erich 2008. Highlight: sphingolipids - signals and disease. Biological chemistry, 389 11, 1347-8

Kornhuber, Johannes; Tripal, Philipp; Reichel, Martin; Terfloth, Lothar; Bleich, Stefan; Wiltfang, Jens; Gulbins, Erich 2008. Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 51 2, 219-37

Lang, Florian; Gulbins, Erich; Lerche, Holger; Huber, Stephan M; Kempe, Daniela S; Foller, Michael 2008. Eryptosis, a window to systemic disease. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 22 5-6, 373-80

Möröy, Tarik; Zeng, Hui; Jin, Jianmin; Schmid, Kurt Werner; Carpinteiro, Alexander; Gulbins, Erich 2008. The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune response. Immunobiology, 213 3-4, 341-52