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Department of

Surgery

Photo of  Ambikaipakan Balasubramaniam, PhD

Ambikaipakan Balasubramaniam, PhD

Professor Emeritus

Education/Credentials
  • Bachelor's Degree: University of Sri Lanka
  • Doctoral Degree: University of Exeter
  • Postdoctoral Research: University of Iowa
  • Postdoctoral Research: University of Illinois
  • Postdoctoral Research: University of Cincinnati

Contact Information
  • Medical Sciences Building
  • Department of Surgery
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-3819
  • Email ambi.bala@uc.edu

Peer Reviewed Publications

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Balasubramaniam, Ambikaipakan; Sheriff, Sulaiman; Friend, Lou Ann; James, J Howard 2018. Phosphodiesterase (PDE) 4B Knock-out Prevents Skeletal Muscle Atrophy in Rats with Burn Injury. American journal of physiology. Regulatory, integrative and comparative physiology, ,

Parker, Michael S; Balasubramaniam, Ambikaipakan; Parker, Steven L 2018. The Expansion Segments of Human 28S rRNA Match MicroRNAs Much Above 18S rRNA or Core Segments. MicroRNA (Shariqah, United Arab Emirates), 7 2, 128-137

Parker, Michael S; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Parker, Steven L 2018. The Expansion Segments of 28S Ribosomal RNA Extensively Match Human Messenger RNAs. Frontiers in genetics, 9 , 66

Parker, Michael S; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Parker, Steven L 2017. Canonical microRNA matching differs greatly across groups of G-protein coupled receptor mRNAs. MicroRNA (Shariqah, United Arab Emirates), ,

Portelli, Jeanelle; Meurs, Alfred; Bihel, Frederic; Hammoud, Hassan; Schmitt, Martine; De Kock, Joery; Utard, Valerie; Humbert, Jean-Paul; Bertin, Isabelle; Buffel, Ine; Coppens, Jessica; Tourwe, Dirk; Maes, Veronique; De Prins, An; Vanhaecke, Tamara; Massie, Ann; Balasubramaniam, Ambikaipakan; Boon, Paul; Bourguignon, Jean-Jacques; Simonin, Frederic; Smolders, Ilse 2015. Neuropeptide FF receptors as novel targets for limbic seizure attenuation. Neuropharmacology, 95 , 415-23

Joshi, Rashika; Kadeer, Nijiati; Sheriff, Sulaiman; Friend, Lou Ann; James, J Howard; Balasubramaniam, Ambikaipakan 2014. Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Molecular and cellular endocrinology, 393 1-2, 152-63

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Park, Edwards A; Sallee, Floyd R; Parker, Steven L 2014. Dimers of G-protein coupled receptors as versatile storage and response units. International journal of molecular sciences, 15 3, 4856-77

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Park, Edwards A; Parker, Steven L 2014. On the expansion of ribosomal proteins and RNAs in eukaryotes. Amino acids, 46 7, 1589-604

Sheriff, Sulaiman; Kadeer, Nijiati; Friend, Lou Ann; James, J Howard; Alexander, J Wesley; Balasubramaniam, Ambikaipakan 2014. Des-acyl-ghrelin (DAG) normalizes hyperlactacidemia and improves survival in a lethal rat model of burn trauma. Peptides, 60 , 1-7

Meurs, Alfred; Portelli, Jeanelle; Clinckers, Ralph; Balasubramaniam, Ambikaipakan; Michotte, Yvette; Smolders, Ilse 2012. Neuropeptide Y increases in vivo hippocampal extracellular glutamate levels through Y1 receptor activation. Neuroscience letters, 510 2, 143-7

Parker, Michael S; Balasubramaniam, Ambikaipakan; Parker, Steven L 2012. On the segregation of protein ionic residues by charge type. Amino acids, 43 6, 2231-47

Sheriff, Sulaiman; Kadeer, Nijiati; Joshi, Rashika; Friend, Lou Ann; James, J Howard; Balasubramaniam, Ambikaipakan 2012. Des-acyl ghrelin exhibits pro-anabolic and anti-catabolic effects on C2C12 myotubes exposed to cytokines and reduces burn-induced muscle proteolysis in rats. Molecular and cellular endocrinology, 351 2, 286-95

Watanabe, Miki; Sheriff, Sulaiman; Lewis, Kenneth B; Cho, Junho; Tinch, Stuart L; Balasubramaniam, Ambikaipakan; Kennedy, Michael A 2012. Metabolic Profiling Comparison of Human Pancreatic Ductal Epithelial Cells and Three Pancreatic Cancer Cell Lines using NMR Based Metabonomics. Journal of molecular biomarkers & diagnosis, 3 2,

Watanabe, Miki; Sheriff, Sulaiman; Lewis, Kenneth B; Tinch, Stuart L; Cho, Junho; Balasubramaniam, Ambikaipakan; Kennedy, Michael A 2012. HMGA-targeted phosphorothioate DNA aptamers increase sensitivity to gemcitabine chemotherapy in human pancreatic cancer cell lines. Cancer letters, 315 1, 18-27

Estes, Anne-Marie; McAllen, Kathleen; Parker, Michael S; Sah, Renu; Sweatman, Trevor; Park, Edwards A; Balasubramaniam, Ambikaipakan; Sallee, Floyd R; Walker, Mary W; Parker, Steven L 2011. Maintenance of Y receptor dimers in epithelial cells depends on interaction with G-protein heterotrimers. Amino acids, 40 2, 371-80

Li, Jiang-Bo; Asakawa, Akihiro; Terashi, Mutsumi; Cheng, KaiChun; Chaolu, Huhe; Zoshiki, Takahiro; Ushikai, Miharu; Sheriff, Sulaiman; Balasubramaniam, Ambikaipakan; Inui, Akio 2010. Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake. Peptides, 31 9, 1706-10

Sheriff, Sulaiman; Ali, Marwan; Yahya, Ayesha; Haider, Khawaja H; Balasubramaniam, Ambikaipakan; Amlal, Hassane 2010. Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line. Molecular cancer research : MCR, 8 4, 604-14

Wang, Yigang; Zhang, Dongsheng; Ashraf, Muhammad; Zhao, Tiemin; Huang, Wei; Ashraf, Atif; Balasubramaniam, Ambikaipakan 2010. Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction. American journal of physiology. Heart and circulatory physiology, 298 1, H275-86

Balasubramaniam, Ambikaipakan; Joshi, Rashika; Friend, Lou Ann; James, J Howard 2009. GHRP-2 attenuates burn-induced dysfunctions in rodents. Advances in experimental medicine and biology, 611 , 571-2

Balasubramaniam, Ambikaipakan; Joshi, Rashika; Su, Chunhua; Friend, Lou Ann; Sheriff, Sulaiman; Kagan, Richard J; James, J Howard 2009. Ghrelin inhibits skeletal muscle protein breakdown in rats with thermal injury through normalizing elevated expression of E3 ubiquitin ligases MuRF1 and MAFbx. American journal of physiology. Regulatory, integrative and comparative physiology, 296 4, R893-901

Sheriff, Sulaiman; Joshi, Rashika; Friend, Lou Ann; James, J Howard; Balasubramaniam, Ambikaipakan 2009. Ghrelin receptor agonist, GHRP-2, attenuates burn injury-induced MuRF-1 and MAFbx expression and muscle proteolysis in rats. Peptides, 30 10, 1909-13

Parker, Steven L; Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd R 2008. Pertussis toxin induces parallel loss of neuropeptide Y Y1 receptor dimers and Gi alpha subunit function in CHO cells. European journal of pharmacology, 579 1-3, 13-25

Parker, Steven L; Parker, Michael S; Wong, Ying Y; Sah, Renu; Balasubramaniam, Ambikaipakan; Sallee, Floyd 2008. Importance of a N-terminal aspartate in the internalization of the neuropeptide Y Y2 receptor. European journal of pharmacology, 594 1-3, 26-31

Balasubramaniam, Ambikaipakan; Joshi, Rashika; Su, Chunhua; Friend, Lou Ann; James, J Howard 2007. Neuropeptide Y (NPY) Y2 receptor-selective agonist inhibits food intake and promotes fat metabolism in mice: combined anorectic effects of Y2 and Y4 receptor-selective agonists. Peptides, 28 2, 235-40

Sah, Renu; Parker, Steven L; Sheriff, Sulaiman; Eaton, Katherine; Balasubramaniam, Ambikaipakan; Sallee, Floyd R 2007. Interaction of NPY compounds with the rat glucocorticoid-induced receptor (GIR) reveals similarity to the NPY-Y2 receptor. Peptides, 28 2, 302-9

Amlal, Hassane; Faroqui, Somia; Balasubramaniam, Ambikaipakan; Sheriff, Sulaiman 2006. Estrogen up-regulates neuropeptide Y Y1 receptor expression in a human breast cancer cell line. Cancer research, 66 7, 3706-14

Balasubramaniam, Ambikaipakan; Mullins, Deborra E; Lin, Shu; Zhai, Wexiu; Tao, Zhiyong; Dhawan, Vikas C; Guzzi, Mario; Knittel, James J; Slack, Katy; Herzog, Herbert; Parker, Eric M 2006. Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity. Journal of medicinal chemistry, 49 8, 2661-5

Balasubramaniam, Ambikaipakan; Wood, Steve; Joshi, Rashika; Su, Chunhua; Friend, Lou Ann; Sheriff, Sulaiman; James, J Howard 2006. Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: synthesis of ghrelin. Peptides, 27 7, 1624-31

Chance, William T; Sheriff, Sulaiman; Dayal, Ramesh; Friend, Lou Ann; Thomas, Ingrid; Balasubramaniam, Ambikaipakan 2006. The role of polyamines in glucagon-like peptide-2 prevention of TPN-induced gut hypoplasia. Peptides, 27 4, 883-92

Parker, Michael S; Sah, Renu; Balasubramaniam, Ambikaipakan; Parker, Steven L 2005. Lithium inhibits internalization and endosomal processing of both neuropeptide Y (NPY) Y1 and transferrin receptors. Neuroscience letters, 374 1, 43-6

Sah, Renu; Balasubramaniam, Ambikaipakan; Parker, Michael S; Sallee, Floyd; Parker, Steven L 2005. Neuropeptide Y as a partial agonist of the Y1 receptor. European journal of pharmacology, 525 1-3, 60-8

Balasubramaniam, Ambikaipakan 2003. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Current pharmaceutical design, 9 15, 1165-75

Chance, William T; Sheriff, Sulaiman; Dayal, Rameshewar; Balasubramaniam, Ambikaipakan 2003. Refractory hypothalamic alpha-mSH satiety and AGRP feeding systems in rats bearing MCA sarcomas. Peptides, 24 12, 1909-19

Jois, Seetharama D S; Balasubramaniam, Ambikaipakan 2003. Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides, 24 7, 1035-43

Parker, Steven L; Parker, Michael S; Buschauer, Armin; Balasubramaniam, Ambikaipakan 2003. Ligand internalization by cloned neuropeptide Y Y5 receptors excludes Y2 and Y4 receptor-selective peptides. European journal of pharmacology, 474 1, 31-42

Balasubramaniam, Ambikaipakan 2002. Clinical potentials of neuropeptide Y family of hormones. American journal of surgery, 183 4, 430-4

Balasubramaniam, Ambikaipakan; Sheriff, Sulaiman; Zhai, Weixu; Chance, William T 2002. Bis(31/31')[[Cys(31), Nva(34)]NPY(27-36)-NH(2)]: a neuropeptide Y (NPY) Y(5) receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides, 23 8, 1485-90

Bell, David; Allen, Adrian R; Kelso, Elizabeth J; Balasubramaniam, Ambikaipakan; McDermott, Barbara J 2002. Induction of hypertrophic responsiveness of cardiomyocytes to neuropeptide Y in response to pressure overload. The Journal of pharmacology and experimental therapeutics, 303 2, 581-91

Sheriff, Sulaiman; F Qureshy, Asbah; T Chance, William; Kasckow, John W; Balasubramaniam, Ambikaipakan 2002. Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]. Peptides, 23 1, 87-96

Balasubramaniam,A.; Rigel,D.F.; Chance,W.T.; Stein,M.; Fischer,J.E.; King,D.; Plisetskaya,E.M. 1990. Salmon pancreatic polypeptide exhibits neuropeptide y-like activities in rats Peptides, 11 4, 673

Balasubramaniam,A.; Sheriff,S. 1990. Neuropeptide y(18-36) is a competitive antagonist of neuropeptide y in rat cardiac ventricular membranes Journal of Biological Chemistry, 265 25, 14724

Balasubramaniam,A.; Sheriff,S.; Ferguson,D.G.; Stein,M.; Rigel,D.F. 1990. N-α-biotinylated-neuropeptide y analogs: syntheses, cardiovascular properties, and application to cardiac npy receptor visualization Peptides, 11 6, 1151

Balasubramaniam,A.; Sheriff,S.; Renugopalakrishnan,V.; Huang,S.G.; Prabhakaran,M.; Chance,W.T.; Fischer,J.E. 1990. Cardiac properties and conformational studies of neuropeptide y (npy) and npy(17-36) Annals of the New York Academy of Sciences, 611 , 355

Balasubramaniam,A.; Sheriff,S.; Rigel,D.F.; Fischer,J.E. 1990. Characterization of neuropeptide y binding sites in rat cardiac ventricular membranes Peptides, 11 3, 545

Ramo,O.J.; Balasubramaniam,A.; Sheriff,S.; Rogers,D.H.; McCullough,P.J.; Bell Jr.,R.H. 1990. Neuropeptide y and peptide yy stimulate the growth of exocrine pancreatic carcinoma cells Neuropeptides, 15 2, 101

Rudnicki,M.; McFadden,D.W.; Liwnicz,B.H.; Balasubramaniam,A.; Nussbaum,M.S.; Dayal,R.; Fischer,J.E. 1990. Endogenous peptide yy is dependent on jejunal exposure to gastrointestinal contents Journal of Surgical Research, 48 5, 485

Sheriff,S.; Rigel,D.F.; Fischer,J.E.; Balasubramaniam,A. 1990. Interaction of 125i-neuropeptide y with rat cardiac membranes Neuropeptides, 15 3, 157

Chance,W.T.; Sheriff,S.; Foley-Nelson,T.; Fischer,J.E.; Balasubramaniam,A. 1989. Pertussis toxin inhibits neuropeptide y-induced feeding in rats Peptides, 10 6, 1283