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Department of

Surgery

Photo of  Michael Helmrath, MD

Michael Helmrath, MD

Professor of Surgery; Director of Surgical Research and Director of Intestinal Rehabilitation Center, CCHMC

Education/Credentials
  • Bachelor's Degree: Miami University - Oxford
  • Medical Degree: University of Cincinnati
  • Master's Degree: University of Cincinnati
  • Research Fellow in Pediatric Surgery: Cincinnati Children's Hospital Medical Center
  • ECMO Fellowship: Cincinnati Children's Hospital Medical Center
  • General Surgery Residency: University of Cincinnati
  • Fellowship in Pediatric Surgery: Baylor College of Medicine, Texas Children's Hospital of Houston

Board Certifications & Licenses
  • Board Certified Diplomate American Board of Surgery, 2001
  • Certification in Pediatric Surgery American Board of Surgery, 2004
  • Medical License State of Ohio, 1998
Contact Information
  • Cincinnati Children's Hospital Medical Center
  • Department of Pediatric Surgery
  • 3333 Burnet Avenue
  • Cincinnati, Ohio 45229
  • Office 513-636-8318
  • Email michael.helmrath@cchmc.org

Peer Reviewed Publications

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Asai, Akihiro; Aihara, Eitaro; Watson, Carey; Mourya, Reena; Mizuochi, Tatsuki; Shivakumar, Pranavkumar; Phelan, Kieran; Mayhew, Christopher; Helmrath, Michael; Takebe, Takanori; Wells, James; Bezerra, Jorge A 2017. Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. Development (Cambridge, England), 144 6, 1056-1064

Bertaux-Skeirik, Nina; Wunderlich, Mark; Teal, Emma; Chakrabarti, Jayati; Biesiada, Jacek; Mahe, Maxime; Sundaram, Nambirajan; Gabre, Joel; Hawkins, Jennifer; Gao, Jian; Engevik, Amy C; Yang, Li; Wang, Jiang; Goldenring, James R; Qualls, Joseph E; Medvedovic, Mario; Helmrath, Michael A; Diwan, Tayyab; Mulloy, James C; Zavros, Yana 2017. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. The Journal of pathology, ,

Inge, Thomas H; Jenkins, Todd M; Xanthakos, Stavra A; Dixon, John B; Daniels, Stephen R; Zeller, Meg H; Helmrath, Michael A 2017. Long-term outcomes of bariatric surgery in adolescents with severe obesity (FABS-5+): a prospective follow-up analysis. The lancet. Diabetes & endocrinology, 5 3, 165-173

Maxime, Mahe M; Brown, Nicole E; Poling, Holly M; Michael, Helmrath A 2017. In Vivo Model of Small Intestine. Methods in molecular biology (Clifton, N.J.), 1597 , 229-245

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621

Workman, Michael J; Mahe, Maxime M; Trisno, Stephen; Poling, Holly M; Watson, Carey L; Sundaram, Nambirajan; Chang, Ching-Fang; Schiesser, Jacqueline; Aubert, Philippe; Stanley, Edouard G; Elefanty, Andrew G; Miyaoka, Yuichiro; Mandegar, Mohammad A; Conklin, Bruce R; Neunlist, Michel; Brugmann, Samantha A; Helmrath, Michael A; Wells, James M 2017. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nature medicine, 23 1, 49-59

Zeller, Meg H; Pendery, Emma C; Reiter-Purtill, Jennifer; Hunsaker, Sanita L; Jenkins, Todd M; Helmrath, Michael A; Inge, Thomas H 2017. From adolescence to young adulthood: trajectories of psychosocial health following Roux-en-Y gastric bypass. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, ,

Cohran, Valeria; Managlia, Elizabeth; Bradford, Emily M; Goretsky, Tatiana; Li, Ting; Katzman, Rebecca B; Cheresh, Paul; Brown, Jeffrey B; Hawkins, Jennifer; Liu, Shirley X L; De Plaen, Isabelle G; Weitkamp, Jörn-Hendrik; Helmrath, Michael; Zhang, Zheng; Barrett, Terrence A 2016. Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection. The American journal of pathology, 186 7, 1837-46

Cushing, Christopher C; Martinez-Leo, Bruno; Bischoff, Andrea; Hall, Jennifer; Helmrath, Michael; Dickie, Belinda H; Levitt, Marc A; Peña, Alberto; Zeller, Meg H; Frischer, Jason S 2016. Health-Related Quality of Life and Parental Stress in Children With Fecal Incontinence: A Normative Comparison. Journal of pediatric gastroenterology and nutrition, 63 6, 633-636

Engevik, Amy C; Feng, Rui; Choi, Eunyoung; White, Shana; Bertaux-Skeirik, Nina; Li, Jing; Mahe, Maxime M; Aihara, Eitaro; Yang, Li; DiPasquale, Betsy; Oh, Sunghee; Engevik, Kristen A; Giraud, Andrew S; Montrose, Marshall H; Medvedovic, Mario; Helmrath, Michael A; Goldenring, James R; Zavros, Yana 2016. The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach. Cellular and molecular gastroenterology and hepatology, 2 5, 605-624

Hirschl, Ronald B; Minneci, Peter; Gadepalli, Samir; Saito, Jacqueline M; Askegard-Giesmann, Johanna; Deans, Katherine; Downard, Cynthia; Fallat, Mary; Finnell, Maria; Helmrath, Michael; Kabre, Rashmi; Lal, David; Leys, Charles; Mak, Grace; Ostlie, Daniel; Rescorla, Fred; Sato, Thomas; St Peter, Shawn; von Allmen, Daniel; Warner, Brad 2016. Development of a multi-institutional clinical research consortium for pediatric surgery. Journal of pediatric surgery, ,

Inge, Thomas H; Courcoulas, Anita P; Jenkins, Todd M; Michalsky, Marc P; Helmrath, Michael A; Brandt, Mary L; Harmon, Carroll M; Zeller, Meg H; Chen, Mike K; Xanthakos, Stavra A; Horlick, Mary; Buncher, C Ralph 2016. Weight Loss and Health Status 3 Years after Bariatric Surgery in Adolescents. The New England journal of medicine, 374 2, 113-23

Lal, Dave R; Gadepalli, Samir K; Downard, Cynthia D; Ostlie, Daniel J; Minneci, Peter C; Swedler, Ruth M; Chelius, Thomas; Cassidy, Laura; Rapp, Cooper T; Deans, Katherine J; Fallat, Mary E; Finnell, S Maria E; Helmrath, Michael A; Hirschl, Ronald B; Kabre, Rashmi S; Leys, Charles M; Mak, Grace; Raque, Jessica; Rescorla, Frederick J; Saito, Jacqueline M; St Peter, Shawn D; von Allmen, Daniel; Warner, Brad W; Sato, Thomas T 2016. Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula. Journal of pediatric surgery, ,

Mezoff, Ethan A; Hawkins, Jennifer A; Ollberding, Nicholas J; Karns, Rebekah; Morrow, Ardythe L; Helmrath, Michael A 2016. The human milk oligosaccharide 2'-fucosyllactose augments the adaptive response to extensive intestinal. American journal of physiology. Gastrointestinal and liver physiology, 310 6, G427-38

Aihara, Eitaro; Mahe, Maxime M; Schumacher, Michael A; Matthis, Andrea L; Feng, Rui; Ren, Wenwen; Noah, Taeko K; Matsu-ura, Toru; Moore, Sean R; Hong, Christian I; Zavros, Yana; Herness, Scott; Shroyer, Noah F; Iwatsuki, Ken; Jiang, Peihua; Helmrath, Michael A; Montrose, Marshall H 2015. Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid. Scientific reports, 5 , 17185

Bout-Tabaku, Sharon; Michalsky, Marc P; Jenkins, Todd M; Baughcum, Amy; Zeller, Meg H; Brandt, Mary L; Courcoulas, Anita; Buncher, Ralph; Helmrath, Michael; Harmon, Carroll M; Chen, Mike K; Inge, Thomas H 2015. Musculoskeletal Pain, Self-reported Physical Function, and Quality of Life in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Cohort. JAMA pediatrics, 169 6, 552-9

Michalsky, Marc P; Inge, Thomas H; Simmons, Mark; Jenkins, Todd M; Buncher, Ralph; Helmrath, Michael; Brandt, Mary L; Harmon, Carroll M; Courcoulas, Anita; Chen, Michael; Horlick, Mary; Daniels, Stephen R; Urbina, Elaine M 2015. Cardiovascular Risk Factors in Severely Obese Adolescents: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study. JAMA pediatrics, 169 5, 438-44

Moon, Changsuk; Zhang, Weiqiang; Sundaram, Nambirajan; Yarlagadda, Sunitha; Reddy, Vadde Sudhakar; Arora, Kavisha; Helmrath, Michael A; Naren, Anjaparavanda P 2015. Drug-induced secretory diarrhea: A role for CFTR. Pharmacological research, 102 , 107-12

Xanthakos, Stavra A; Jenkins, Todd M; Kleiner, David E; Boyce, Tawny W; Mourya, Reena; Karns, Rebekah; Brandt, Mary L; Harmon, Carroll M; Helmrath, Michael A; Michalsky, Marc P; Courcoulas, Anita P; Zeller, Meg H; Inge, Thomas H 2015. High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery. Gastroenterology, ,

Zeller, Meg H; Inge, Thomas H; Modi, Avani C; Jenkins, Todd M; Michalsky, Marc P; Helmrath, Michael; Courcoulas, Anita; Harmon, Carroll M; Rofey, Dana; Baughcum, Amy; Austin, Heather; Price, Karin; Xanthakos, Stavra A; Brandt, Mary L; Horlick, Mary; Buncher, Ralph 2015. Severe obesity and comorbid condition impact on the weight-related quality of life of the adolescent patient. The Journal of pediatrics, 166 3, 651-9.e4

Inge, Thomas H; Boyce, Tawny W; Lee, Margaret; Kollar, Linda; Jenkins, Todd M; Brandt, Mary L; Helmrath, Michael; Xanthakos, Stavra A; Zeller, Meg H; Harmon, Carroll M; Courcoulas, Anita; Michalsky, Marc P 2014. Access to care for adolescents seeking weight loss surgery. Obesity (Silver Spring, Md.), 22 12, 2593-7

Inge, Thomas H; Zeller, Meg H; Jenkins, Todd M; Helmrath, Michael; Brandt, Mary L; Michalsky, Marc P; Harmon, Carroll M; Courcoulas, Anita; Horlick, Mary; Xanthakos, Stavra A; Dolan, Larry; Mitsnefes, Mark; Barnett, Sean J; Buncher, Ralph 2014. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA pediatrics, 168 1, 47-53

Michalsky, Marc P; Inge, Thomas H; Teich, Steven; Eneli, Ihuoma; Miller, Rosemary; Brandt, Mary L; Helmrath, Michael; Harmon, Carroll M; Zeller, Meg H; Jenkins, Todd M; Courcoulas, Anita; Buncher, Ralph C 2014. Adolescent bariatric surgery program characteristics: the Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study experience. Seminars in pediatric surgery, 23 1, 5-10

Xiao, Nianzhou; Jenkins, Todd M; Nehus, Edward; Inge, Thomas H; Michalsky, Marc P; Harmon, Carroll M; Helmrath, Michael A; Brandt, Mary L; Courcoulas, Anita; Moxey-Mims, Marva; Mitsnefes, Mark M 2014. Kidney function in severely obese adolescents undergoing bariatric surgery. Obesity (Silver Spring, Md.), 22 11, 2319-25

Eradi, Balgopal; Hamrick, Miller; Bischoff, Andrea; Frischer, Jason S; Helmrath, Michael; Hall, Jennifer; Peña, Alberto; Levitt, Marc A 2013. The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence. Journal of pediatric surgery, 48 11, 2296-300

Ubesie, Agozie C; Kocoshis, Samuel A; Mezoff, Adam G; Henderson, Carol J; Helmrath, Michael A; Cole, Conrad R 2013. Multiple micronutrient deficiencies among patients with intestinal failure during and after transition to enteral nutrition. The Journal of pediatrics, 163 6, 1692-6

Dehmer, Jeffrey J; Fuller, Megan K; Helmrath, Michael A 2011. Management of pediatric intestinal failure. Advances in pediatrics, 58 1, 181-94

Hamrick, Miller; Helmrath, Michael; Bischoff, Andrea; Eradi, Balgopal; Levitt, Marc; Peña, Alberto 2011. Letter to the Editor regarding comparison of anorectal angle and continence after Georgeson and Peña procedures for high/intermediate imperforate anus. Journal of pediatric surgery, 46 5, 1019-20; author repl

Brandt, Mary L; Harmon, Carroll M; Helmrath, Michael A; Inge, Thomas H; McKay, Siripoom V; Michalsky, Marc P 2010. Morbid obesity in pediatric diabetes mellitus: surgical options and outcomes. Nature reviews. Endocrinology, 6 11, 637-45

Inge, Thomas; Helmrath, Michael; Vierra, Mark 2010. The Santoro III massive enterectomy: how can we justify the risks in obese adolescents? Obesity surgery, 20 12, 1718-9

Garrison, Aaron P; Helmrath, Michael A; Dekaney, Christopher M 2009. Intestinal stem cells. Journal of pediatric gastroenterology and nutrition, 49 1, 2-7

Inge, Thomas H; Miyano, Go; Bean, Judy; Helmrath, Michael; Courcoulas, Anita; Harmon, Carroll M; Chen, Mike K; Wilson, Kimberly; Daniels, Stephen R; Garcia, Victor F; Brandt, Mary L; Dolan, Lawrence M 2009. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics, 123 1, 214-22

Inge, Thomas; Helmrath, Michael; Vierra, Mark; Ikramuddin, Sayeed 2008. Challenges of adolescent bariatric surgery: tips for managing the extremely obese teen. Journal of laparoendoscopic & advanced surgical techniques. Part A, 18 1, 157-69

De Silva, Nirupama K; Helmrath, Michael A; Klish, William J 2007. Obesity in the adolescent female. Journal of pediatric and adolescent gynecology, 20 3, 207-13

Fuller, Megan K; Helmrath, Michael A 2007. Thoracic empyema, application of video-assisted thoracic surgery and its current management. Current opinion in pediatrics, 19 3, 328-32

Inge, Thomas H; Zeller, Meg; Harmon, Carroll; Helmrath, Michael; Bean, Judy; Modi, Avani; Horlick, Mary; Kalra, Maninder; Xanthakos, Stavra; Miller, Rosemary; Akers, Rachel; Courcoulas, Anita 2007. Teen-Longitudinal Assessment of Bariatric Surgery: methodological features of the first prospective multicenter study of adolescent bariatric surgery. Journal of pediatric surgery, 42 11, 1969-71

Helmrath, Michael A; Brandt, Mary L; Inge, Thomas H 2006. Adolescent obesity and bariatric surgery. The Surgical clinics of North America, 86 2, 441-54, x

Kenton, Alexander B; Hegemier, Suzanne; Smith, E O'Brian; O'Donovan, Donough J; Brandt, Mary L; Cass, Darrell L; Helmrath, Michael A; Washburn, Kimberly; Weihe, Elizabeth K; Fernandes, Caraciolo J 2005. Platelet transfusions in infants with necrotizing enterocolitis do not lower mortality but may increase morbidity. Journal of perinatology : official journal of the California Perinatal Association, 25 3, 173-7

Kenton, Alexander B; O'Donovan, Donough; Cass, Darrell L; Helmrath, Michael A; Smith, E O'brian; Fernandes, Caraciolo J; Washburn, Kimberly; Weihe, Elizabeth K; Brandt, Mary L 2005. Severe thrombocytopenia predicts outcome in neonates with necrotizing enterocolitis. Journal of perinatology : official journal of the California Perinatal Association, 25 1, 14-20

Inge, Thomas H; Krebs, Nancy F; Garcia, Victor F; Skelton, Joseph A; Guice, Karen S; Strauss, Richard S; Albanese, Craig T; Brandt, Mary L; Hammer, Lawrence D; Harmon, Carol M; Kane, Timothy D; Klish, William J; Oldham, Keith T; Rudolph, Colin D; Helmrath, Michael A; Donovan, Edward; Daniels, Stephen R 2004. Bariatric surgery for severely overweight adolescents: concerns and recommendations. Pediatrics, 114 1, 217-23

Klish, William J; Brandt, Mary L; Helmrath, Michael A 2004. Obesity surgery in pediatrics. Journal of pediatric gastroenterology and nutrition, 39 1, 2-4