Neuroradiology Imaging Research
Current
MR RESCUE (MR & Recanalization of Stroke Clots Using Embolectomy)
Investigator: Thomas A. Tomsick, MD
Sponsor: NIH/NINDS P50 NS44378
Clinical Trials Sub-award with UCLA (Coordinating Center)
IRB Approval: 11-May-2005 (ongoing)
Multicenter, randomized, blinded outcome evaluator, phase IIb trial to investigate whether diffusion-perfusion MRI can identify patients who will benefit substantially from mechanical Embolectomy with the Concentric MERCI® Retriever device for the treatment of acute ischemic stroke up to 8 hours from symptom onset. Randomization stratified by MRI pattern (penumbral vs non-penumbral.
Modeling Modes of Intracranial Aneurysm Recurrence After Coil Embolization: Mechanisms of Coil Compaction and Aneurysm Growth
Investigator: Todd Abruzzo, MD
Sponsor: The Neuroradiology Education and Research Foundation
IRB Approval: 09-Dec-2007 (ongoing)
The primary purpose of this study is to demonstrate that intracranial aneurysm recurrence after coil embolization involves a combination of aneurysm growth and coil compaction.
CT Perfusion Imaging to Study Hemodynamics of Moya Moya Disease and CT Angiograms and CT Perfusion for Evaluation of Extracranial-Intracranial Bypass Surgery
Investigator: Achala Vagal, MD.Sponsor: Investigator Initiated
IRB Approval: 20-Sep-2007 (ongoing)
Retrospective review of patients imaged and treated by Drs. Vagal and Zuccarello who have undergone CT perfusion imaging to study hemodynamics of Moya Moya disease and CTA and CT perfusion for evaluation of EC-IC bypass surgery.
Assessing Adequacy of Automatic Bone Subtraction Technique in Cranial CT Angiography Utilizing a Duel Energy CT Scanner
Investigator: Achala Vagal, MD
Sponsor: Investigator Initiated
IRB Approval: 14-Feb-2009 (ongoing)
Retrospective review of approximately 50 patients that underwent CTA imaging studies for clinical purposes since January 2008 in TUH Department of Radiology to assess the adequacy of bone removal in cranial CTA performed on duel energy CT scanners using automated bone subtraction software. Bone subtraction aims to improve CTA interpretation by eliminating bony overlap and enabling improved evaluation of the intracranial circulation.
The Possible Association of Venous Anomalies with Primary Brain Tumors
Investigator: Achala Vagal, MD
Sponsor: Investigator Initiated
IRB Approval: Submission pending
Retrospective review of approximately 700 patients that underwent MRI imaging studies since 2000 to identify patients with anomalous venous structures and primary brain neoplasms.
Functional MRI and Advanced MR Imaging at 3T: Utilization for Pre-Operative Planning and Integration with Intra-Operative Neuronavigation
Investigator: James Leach, MD
Co-Investigator: Christopher McPherson, MD
Sponsor: Investigator Initiated
The purpose of this study is to determine how useful fMRI and brain white matter tractography are as a tool to aid neurosurgeons in visualizing delicate areas of brain function, such as speech and movement, during operative procedures to treat brain abnormalities such as tumors, AVMs, and movement disorders.
Interventional Management of Stroke (IMS III) Study
Co-Investigator: Thomas Tomsick, MD
Sponsor: NIH / NINDS U01-NS052220
IRB Approval: Sept-2005 (ongoing)
An international phase III, randomized, multi-center, open label, 900 subject clinical trial that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalization is superior to standard IV rt-PA alone when initiated within three hours of acute ischemic stroke onset.
The Spot Sign for Predicting and Treating ICH Growth (STOP-IT) Study
Co-Investigator: Thomas Tomsick, MD
Sponsor: NIH / NINDS 2P50NS044283
IRB Approval: 16-Jul-09 (ongoing)
A phase II, randomized, multicenter, double-blind, placebo-controlled trial comparing rFVIIa to placebo for treatment of subjects with acute ICH and contrast extravasation (the spot sign) identified on CTA.
Specialized Program of Translational Research in Acute Stroke (SPOTRIAS)
Investigator: Thomas A. Tomsick, MD
Sponsor: NIH/NINDS P50-NS44283
The goal of the neuro-imaging core is to collect, de-identify, transfer, and store, brain imaging from participating SPOTRIAS subjects, particularly subjects entered into the SPOTRIAS Trials (CLEARER, STOP-IT, and MR Rescue). One of the goals of this core is for all SPOTRIAS Centers to develop a shared database of de-identified image data, linked to phenotypic and genetic data that can be used by SPOTRIAS network investigators as well as other investigators.
Automated Neuroaxis MRI Screen in Children
Investigator: Kenneth Weiss, MD
Sponsor: $100,000 by the State of Ohio
Study aims to provide Hamilton County’s at-risk children with no-cost brain and spine MRI studies. This latest technology rapidly screens the brain and spine using MRI and computer automation. In combination with GE’s pre-clinical release software “Pedi Pack” rapid state of the art imaging of pediatric neurologic disorders is now available at UC. Children between the ages of 6-17 with known or suspected neurological conditions can be entered into this research study. The mission is to reduce the need for sedation, X-radiation and the high imaging cost associated with diagnosis and surveillance of children with chronic neurological conditions. For physician referrals, contact Weiss at (513) 584-1584.