Breast Imaging Research
Current
Clinical Utility and Initial Experience with Positron Emission Mammography Imaging Using High Resolution PEM Flex® Solo II PET Scanner and Stereo Navigator® Biopsy Accessory for the Diagnosis of Breast Cancer
Investigator: Mary C. Mahoney, MD
Sponsor: Naviscan, Inc.
IRB Approval: 08-19-2009 (not open to accrual)
PEM is a functional imaging modality that provides high resolution, accurate detection of primary breast cancers, but its use has not been conclusively studied. This is a prospective study whose goal is to evaluate if the use of PEM at the time of a newly diagnosed breast cancer can yield complete and accurate pre-surgical diagnosis and staging in an expedited manner compared to conventional diagnosis and staging.
Fibrous Lesions of the Breast: A Retrospective Review of Magnetic Resonance Imaging Features and Literature Review
Investigator: Su-Ju Lee, MD
Sponsor: Investigator Initiated
IRB Approval: 06-20-2009 (open)
This is a retrospective review study being conducted to present the MR imaging features of fibrous lesions of the breast and review the related literature. The goal of this study is to gain knowledge of the clinical and MRI presentations of these lesions so that radiologists may better determine radiologic-pathologic correlation of biopsy results and determine appropriate patient management.
Granular Cell Tumors of the Breast: A Retrospective Review of Imaging Features and Literature Review
Investigator: Su-Ju Lee, MD
Sponsor: Investigator Initiated
IRB Approval: 02-09-2009 (open)
This is a retrospective review study being conducted to present the spectrum of imaging features of granular cell tumors (GCTs) of the breast, an uncommon neoplasm of the breast, and review the literature on GCTs.
Breast MRI Post-operative Enhancement: Characteristics and Amount of Time to Resolution
Investigator: Amy Argus, MD and Mary Mahoney, MD
Sponsor: Investigator Initiated
IRB Approval: 12-01-2008 (open)
This is a retrospective review study being performed to investigate the characteristics of the post-operative breast MRI and determine the expected patterns and time course for resolution of post-treatment changes. The goal of the study is to have a more thorough understanding of post-treatment changes so as to better recognize early tumor recurrence.
1H MR Spectroscopy to Improve Diagnostic Accuracy of Breast Magnetic Resonance Imaging
Investigator: Mary Mahoney, MD
Sponsor: Investigator Initiated (collaborative study between the Department of Radiology and Center for Imaging Research)
IRB Approval: 08-06-2008 (open)
This is a prospective study being conducted to evaluate the diagnostic performance of high field magnetic resonance spectroscopy in distinguishing benign from malignant breast tissue by using histological findings as the reference standard. Women who are18 years or older with a suspicious breast finding seen on imaging and are scheduled for a breast biopsy may be eligible.
Incidence of Cancer or High Risk Pathology in Benign Breast Papillomas Diagnosed at Core Biopsy
Investigator: Virginia Molleran, MD
Sponsor: Investigator Initiated
IRB Approval: 04-30-2008 (open)
This is a retrospective review study being performed to determine the incidence of malignancy or high risk pathology in lesions initially diagnosed as benign papilloma at core needle biopsy of the breast. The goal of the study is to better help physicians determine appropriate patient management
Percutaneous Excision Trial I-PET: A Multi-Center Clinical Study of the Intact Breast Lesion Excision System (BLES) to Demonstrate that a Definitive Diagnosis can be made from the Tissue Sample Collected with the Intact BLES
Investigator: Mary Mahoney, MD
Sponsor: Intact Medical Corporation.
IRB approval: 02-14-2007 (open)
This is a prospective, multi-site, non-randomized, study to confirm that surgical intervention can be avoided by using the Intact BLES for a definitive diagnosis of atypical ductal hyperplasia. The Intact BLES is a unique FDA approved sampling device which is able to remove a lumpectomy like tissue sample instead of multiple core biopsy samples when performing a percutaneous biopsy.
High Field Magnetic Resonance Spectroscopy of Breast Biopsy Specimens
Investigator: Mary Mahoney, MD
Sponsor: Investigator Initiated (collaborative study between the Department of Radiology and Center for Imaging Research)
IRB Approval: 09-27-2006 (open)
This is a prospective study being conducted to evaluate the feasibility of performing high field spectroscopy of breast biopsy specimens and to determine the accuracy of distinguishing benign from malignant tissue. Women who are18 years or older with a suspicious breast finding seen on imaging and are scheduled for a breast biopsy may be eligible.