 Christy K. Holland graduated cum laude from Wellesley College in 1983 with a B.A. degree in physics and music. She completed graduate work (M.S. '85, M.Phil. '87, Ph.D. '89) in Engineering and Applied Sciences in the laboratory of Robert E. Apfel. Dr. Holland pursued a postdoctoral fellowship under the guidance of Kenneth J. W. Taylor, M.D., Ph.D. in Diagnostic Radiology at the Yale School of Medicine.
Dr. Holland is a fellow of the American Institute of Ultrasound in Medicine and serves on its Board of Governors. She is also a member of the Acoustical Society of America and serves on its Biomedical Ultrasound Technical Committee and its Executive Council.
Dr. Holland's research interests focus on the interaction of ultrasound with tissue, either for diagnosis or therapy. She is director of the Ultrasound Laboratory in the Department of Radiology at the University of Cincinnati.
An ongoing study on the mechanical bioeffects due to diagnostic ultrasound is funded by the National Institute of Health. The major goals of this project are to clarify the potential risks involved in the use of diagnostic ultrasound scanners near aerated lung or in the presence of an echo contrast agent.
In another study that received funding from the Whitaker Foundation and a Radiology Department Seed Grant, turbulent flow in arteries is assessed noninvasively with Doppler ultrasound. Non-invasive, quantitative, state-of-the-art diagnostic imaging techniques are being developed for determining the grade of arterial stenoses by tracking turbulence in the post-stenotic jet.
A transcranial ultrasound thrombolysis system that utilizes low energy ultrasound to enhance the drug-mediated clot dissolution is also being developed. The underlying acoustic and biochemical mechanisms for the enhancement of thrombolysis are not well understood. We hypothesize that ultrasound enhances thrombolysis via a cavitational mechanism, and experimental data are being acquired to elucidate the efficacy of combining transcranial ultrasound with intravenous administration of t-PA.
Selected Publications
AIUM, "Mechanical Bioeffects from Diagnostic Ultrasound: AIUM Consensus Statements", in J. Ultrasound Med., J. B. Fowlkes and C. K. Holland, Guest Eds., 19: 68-168 (2000).
C. K. Holland, J. M. Brown, L. M. Scoutt, K. J. W. Taylor, "Lower extremity volumetric arterial blood flow in normal subjects" Ultrasound Med. Biol., 24, 1079-1086 (1998).
R. E. Apfel and C. K. Holland, "Gauging the likelihood of cavitation from short pulse, low duty cycle diagnostic ultrasound", Ultrasound Med. Biol., 17, 179-185 (1991).
christy.holland@uc.edu
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