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Grant Awarded to Study Repair of Gastric Microlesions
04/15/2005
MCP today learned of the award of a 5-year NIH grant to study how cells in the lining of the stomach work to repair tiny lesions that result from the action of drugs (such as NSAIDs), Helicobacter pylori infection (which often leads to ulcers), and the daily "wear and tear" and cell turnover.
Principal investigator, UC professor and chair of molecular and cellular physiology, Marshall Montrose, PhD, said, "The grant follows our recent discovery that two-photon microscopy can be used to induce epithelial damage to 2-3 cells lining the stomach of mice, such that we can then track the process of cell death and epithelial repair in real-time. Since this type of damage occurs daily due to rapid cell turnover in the epithelium, and small nicking of the tissue by foodstuffs, we have a unique approach that will allow us to define the molecules that control the balance between expanding damage versus repair. In pathological conditions, this balance is disturbed and can lead to gastroduodenal ulcers."
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