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Jay R. Hove, PhD
Associate Professor
jay.hove@uc.edu

Our laboratory utilizes both physiological and bioengineering approaches to determine the roles of biophysical forces, both within and around living systems, on both healthy and pathological form and function. We are particularly interested in the purported role of biological fluid flow as a morphogen for a variety of human diseases including cardiovascular disease, polycystic kidney disease, and obesity. These research efforts frequently require analysis across a wide range of biological organization, from the intact organism, to the tissues that compose the living conduits through which biofluids flow, down to the developmental gene expression program that serves to effect changes in the functional phenotype. With our colleagues, we are also developing a new suite of phenotyping tools with which to more effectively interrogate a powerful new animal model system of human disease, the zebrafish.

Visit the Hove Lab Homepage.




Selected Publications:
  • Scott W Mittelstadt, Cynthia L Hemenway, Michael P Craig and Jay R Hove (2008) Evaluation of zebrafish embryos as a model for assessing inhibition of hERG. J Pharmacol Toxicol Methods 57, 100-105.
    View original publication at Science Direct.com
  • Jay R Hove (2006) Quantifying cardiovascular flow dynamics during early development. Pediatr Res 60, 6-13. [Review]
    View original publication at Pediatric Research online.
  • Michael P Craig, Steven D Gilday and Jay R Hove (2006) Dose-dependent effects of chemical immobilization on the heart rate of embryonic zebrafish. Lab Anim (NY) 35, 41-7.
    View original publication at LabAnimal.com.
  • Arian S Forouhar, Michael Liebling, Anna Hickerson, Abbas Nasiraei-Moghaddam, Huai-Jen Tsai, Jay R Hove, Scott E Fraser, Mary E Dickinson and Morteza Gharib (2006) The embryonic vertebrate heart tube is a dynamic suction pump. Science 312, 751-753.
    View original publication at Sciencemag.org.
  • Jay R Hove, Reinhard W Kšster, Arian S Forouhar, Gabriel Acevedo-Bolton, Scott E Fraser and Morteza Gharib (2003) Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 421, 172-177.
    View original publication at nature.com.

Publications, Complete List at PubMed


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