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 John Cuppoletti, PhD
Professor
john.cuppoletti@uc.edu
Our research interests are in the pumps, carriers, and ion channels of the epithelia. Our research has focused on transport proteins and transport processes of the gastrointestinal tract and lung. In recent years, potassium and chloride channel regulation, pharmacology, and molecular engineering have become increasingly important tools with which to study the functional mechanisms of these proteins. More recently, as the X-ray crystal structures of these proteins have become available, we have combined these types of studies with computational chemistry approaches in attempts to understand the fundamental processes of protein gating that underlie function and gating of these channels. We have also placed these transport proteins into synthetic membranes in order to obtain more detailed information regarding protein function that cannot be obtained from purely biological membranes. |
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Selected Publications:
- John Cuppoletti, Danuta H Malinowska, Jayati Chakrabarti and Ryuji Ueno (2008) Effects of lubiprostone on human uterine smooth muscle cells. Prostaglandins Other Lipid Mediat 86, 56-60.
View original publication at Science Direct.com.
- John Cuppoletti, Danuta H Malinowska, Kirti P Tewari, Jayati Chakrabarti and Ryuji Ueno (2007) Cellular and molecular effects of unoprostone as a BK channel activator. Biochim Biophys Acta 1768, 1083-92.
View original publication at ScienceDirect.com.
- Nobunaka Matsuno, Michael Murawsky, James Ridgeway and John Cuppoletti (2004) Solid support membranes for ion channel arrays and sensors: application to rapid screening of pharmacological compounds. Biochim Biophys Acta 1665, 184-190.
View original publication at ScienceDirect.com.
- John Cuppoletti, Danuta H Malinowska, Kirti P Tewari, Qiu-Ju Li, Ann M Sherry, Myra L Patchen and Ryuji Ueno (2004) SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol 287, C1173-C1183.
View original publication at AJP:Cell Online.
- John Cuppoletti, Kirti P Tewari, Ann M Sherry, Christopher J Ferrante and Danuta H Malinowska (2004) Sites of protein kinase A activation of the human ClC-2 ClÑ channel. J Biol Chem 279, 21849-21856.
View original publication at JBC.org.
- John Cuppoletti (2000) Possible role of ion channels in the action of nonsteroidal anti-inflammatory drugs. News Physiol Sci 15, 106.
View original publication at Physiology Online.
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Other Publications, Not Listed in PubMed:
- John Cuppoletti and Danuta H Malinwska (2006) Ion channels of the epithelia of the gastrointestinal tract, ch 75 in: Physiology of the Gastrointestinal Tract, vol 1-2, 4e, Leonard R Johnson (Ed-in-Chief), Kim E Barrett, Fayez K Ghishan, Juanita L Merchant, Hamid M Said, and Jackie D Wood (Eds), Academic Press, Burlington, pp 1917-1930 (Review).
View details at Elsevier.com.
Buy the book at Amazon.com.
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