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Department of

Pathology and Laboratory Medicine

Photo of  Min Liu, PhD

Min Liu, PhD

Professor

Education/Credentials
  • Doctorate: Peking Union Medical College & Chinese Academy of Medical Sciences (PUMC & CAMS)

Research/Clinical Interests

Dr. Liu's laboratory is currently studying the role of hypothalamic apolipoprotein AIV (apo AIV) in the development of obesity and how it can be modulated for preventive and therapeutic purposes. Apo AIV is a circulating signal released from intestinal cells in response to lipid feeding, and it contributes to the anorectic effect of a lipid meal. We have demonstrated that apo AIV is also synthesized in the hypothalamus, and that hypothalamic apo AIV gene and protein expression is regulated physiologically.

Contact Information

Peer Reviewed Publications

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Duan, Yuping; Zhu, Wei; Liu, Min; Ashraf, Muhammad; Xu, Meifeng 2017. The expression of Smad signaling pathway in myocardium and potential therapeutic effects. Histology and histopathology, 32 7, 651-659

Gong, Min; Yu, Bin; Wang, Jingcai; Wang, Yigang; Liu, Min; Paul, Christian; Millard, Ronald W; Xiao, De-Sheng; Ashraf, Muhammad; Xu, Meifeng 2017. Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis. Oncotarget, ,

May, Aaron A; Bedel, Nicholas D; Shen, Ling; Woods, Stephen C; Liu, Min 2016. Estrogen and insulin transport through the blood-brain barrier. Physiology & behavior, 163 , 312-321

May, Aaron A; Liu, Min; Woods, Stephen C; Begg, Denovan P 2016. CCK increases the transport of insulin into the brain. Physiology & behavior, 165 , 392-7

Wang, H H; Liu, M; Portincasa, P; Tso, P; Wang, D Q-H 2016. Lack of endogenous cholecystokinin promotes cholelithogenesis in mice. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 28 3, 364-75

Woods, Stephen C; May, Aaron A; Liu, Min; Tso, Patrick; Begg, Denovan P 2016. Using the cerebrospinal fluid to understand ingestive behavior. Physiology & behavior, ,

Begg, Denovan P; May, Aaron A; Mul, Joram D; Liu, Min; D'Alessio, David A; Seeley, Randy J; Woods, Stephen C 2015. Insulin Detemir Is Transported From Blood to Cerebrospinal Fluid and Has Prolonged Central Anorectic Action Relative to NPH Insulin. Diabetes, 64 7, 2457-66

de Bari, Ornella; Wang, Helen H; Portincasa, Piero; Liu, Min; Wang, David Q-H 2015. The deletion of the estrogen receptor ? gene reduces susceptibility to estrogen-induced cholesterol cholelithiasis in female mice. Biochimica et biophysica acta, 1852 10 Pt A, 2161-9

de Bari, Ornella; Wang, Tony Y; Liu, Min; Portincasa, Piero; Wang, David Q-H 2015. Estrogen induces two distinct cholesterol crystallization pathways by activating ER? and GPR30 in female mice. Journal of lipid research, 56 9, 1691-700

Kohan, Alison B; Wang, Fei; Lo, Chun-Min; Liu, Min; Tso, Patrick 2015. ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety. American journal of physiology. Gastrointestinal and liver physiology, 308 6, G472-81

Li, Xiaoming; Xu, Min; Liu, Min; Ji, Yong; Li, Zongfang 2015. TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells. Journal of inflammation (London, England), 12 , 22

Shen, Ling; Haas, Michael; Wang, David Q-H; May, Aaron; Lo, Chunmin C; Obici, Silvana; Tso, Patrick; Woods, Stephen C; Liu, Min 2015. Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats. Physiological reports, 3 9,

Shen, Ling; Wang, David Q-H; Lo, Chunmin C; Arnold, Myrtha; Tso, Patrick; Woods, Stephen C; Liu, Min 2015. Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats. Physiology & behavior, 152 Pt A, 62-7

Wang, Fei; Kohan, Alison B; Lo, Chun-Min; Liu, Min; Howles, Philip; Tso, Patrick 2015. Apolipoprotein A-IV: a protein intimately involved in metabolism. Journal of lipid research, 56 8, 1403-18

Shen, Ling; Liu, Yin; Wang, David Q H; Tso, Patrick; Woods, Stephen C; Liu, Min 2014. Estradiol stimulates apolipoprotein A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-?. Endocrinology, 155 10, 3882-90

Begg, Denovan P; Mul, Joram D; Liu, Min; Reedy, Brianne M; D'Alessio, David A; Seeley, Randy J; Woods, Stephen C 2013. Reversal of diet-induced obesity increases insulin transport into cerebrospinal fluid and restores sensitivity to the anorexic action of central insulin in male rats. Endocrinology, 154 3, 1047-54

Shen, Ling; Xiong, Ye; Wang, David Q-H; Howles, Philip; Basford, Joshua E; Wang, Jiang; Xiong, Yu Qing; Hui, David Y; Woods, Stephen C; Liu, Min 2013. Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats. Journal of lipid research, 54 5, 1430-8

Liu, Min; Kuhel, David G; Shen, Ling; Hui, David Y; Woods, Stephen C 2012. Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice. American journal of physiology. Regulatory, integrative and comparative physiology, 303 9, R903-8

Liu, Min; Shen, Ling; Begg, Denovan P; D'alessio, David A; Woods, Stephen C 2012. Insulin increases central apolipoprotein E levels as revealed by an improved technique for collection of cerebrospinal fluid from rats. Journal of neuroscience methods, 209 1, 106-12

Lo, Chunmin C; Langhans, Wolfgang; Georgievsky, Maria; Arnold, Myrtha; Caldwell, Jody L; Cheng, Stacy; Liu, Min; Woods, Stephen C; Tso, Patrick 2012. Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake. Endocrinology, 153 12, 5857-65

Shen, Ling; Hillebrand, Allix; Wang, David Q-H; Liu, Min 2012. Isolation and primary culture of rat hepatic cells. Journal of visualized experiments : JoVE, 64,

Yoshimichi, Go; Lo, Chunmin C; Tamashiro, Kellie L K; Ma, Liyun; Lee, Dana M; Begg, Denovan P; Liu, Min; Sakai, Randall R; Woods, Stephen C; Yoshimatsu, Hironobu; Tso, Patrick 2012. Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice. American journal of physiology. Gastrointestinal and liver physiology, 302 11, G1336-42

Lo, Chun-Min; Obici, Silvana; Dong, H Henry; Haas, Michael; Lou, Dawnwen; Kim, Dae Hyun; Liu, Min; D'Alessio, David; Woods, Stephen C; Tso, Patrick 2011. Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice. Diabetes, 60 7, 2000-7

Shen, Ling; Wang, David Q-H; Tso, Patrick; Jandacek, Ronald J; Woods, Stephen C; Liu, Min 2011. Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus. Physiology & behavior, 105 1, 124-8

Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min 2010. Estradiol increases the anorectic effect of central apolipoprotein A-IV. Endocrinology, 151 7, 3163-8

Xiong, Ye; Shen, Ling; Liu, Kristina J; Tso, Patrick; Xiong, Yuqing; Wang, Guangji; Woods, Stephen C; Liu, Min 2010. Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes, 59 10, 2505-12

Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick 2009. Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration. American journal of physiology. Regulatory, integrative and comparative physiology, 296 1, R43-50

Shen, Ling; Carey, Katherine; Wang, David Q-H; Woods, Stephen C; Liu, Min 2009. Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats. Brain research, 1273 , 66-71

Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min 2009. Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats. Physiology & behavior, 98 1-2, 223-8

Shen L, Pearson KJ, Xiong Y, Lo CM, Tso P, Woods SC, Davidson WS, Liu M 2008. Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis Physiol Behav, 95 1-2, 161-7

Shen L, Tso P, Woods, S.C., Clegg, BJ, Barber KL, Carey K, Liu M. 2008. Brain Apolipoprotein E: An Important Regulator of Food Intake in Rats. Diabetes. Diabetes, 57 8, 2092-8

Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min 2008. Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis. Physiology & behavior, 95 1-2, 161-7

Shen, Ling; Tso, Patrick; Woods, Stephen C; Clegg, Deborah J; Barber, Kyna L; Carey, Katherine; Liu, Min 2008. Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes, 57 8, 2092-8

Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick 2007. Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1490-4

Lo, Chun-Min; Ma, Liyun; Zhang, Dian Ming; Lee, Rachel; Qin, Abby; Liu, Min; Woods, Stephen C; Sakai, Randall R; Raybould, Helen E; Tso, Patrick 2007. Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. American journal of physiology. Regulatory, integrative and comparative physiology, 292 1, R268-73

Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min 2007. Hypothalamic apolipoprotein A-IV is regulated by leptin. Endocrinology, 148 6, 2681-9

Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean 2007. Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini. The Journal of biological chemistry, 282 39, 28385-94

Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C 2006. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. American journal of physiology. Regulatory, integrative and comparative physiology, 290 1, R202-7

Jandacek, R., Anderson N., Liu, M., Zheng, S., Yang, Q., Tso, P 2005. Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene American Journal of Physiology-Gastrointestinal and Liver physiology, 288 , G292-9

Jandacek, Ronald J; Anderson, Nicole; Liu, Min; Zheng, Shuqin; Yang, Qing; Tso, Patrick 2005. Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. American journal of physiology. Gastrointestinal and liver physiology, 288 2, G292-9

Pearson, K., Liu, M., Shen L., Woods, S.C., Tso P., Davidson, W. S 2005. Bacterial expression and characterization of rat and mouse apolipoprotein E. Protein Expression and Purification, 41 , 447-53

Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean 2005. Bacterial expression and characterization of rat apolipoprotein E. Protein expression and purification, 41 2, 447-53

Qin, Xiaofa; Shen, Hui; Liu, Min; Yang, Qing; Zheng, Shuqin; Sabo, Mary; D'Alessio, David A; Tso, Patrick 2005. GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. American journal of physiology. Gastrointestinal and liver physiology, 288 5, G943-9

Shen, L., Ma, L.Y., Jandacek R. and Sakai, R. Liu, M 2005. Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats. American Journal of Physiology-Gastrointestinal and Liver physiology, 288 , G48-53

Shen, Ling; Ma, Li-yun; Qin, Xiao-fa; Jandacek, Ronald; Sakai, Randall; Liu, Min 2005. Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats. American journal of physiology. Gastrointestinal and liver physiology, 288 1, G48-53

Liu, Min; Shen, Ling; Liu, Yin; Tajima, Daisuke; Sakai, Randall; Woods, Stephen C; Tso, Patrick 2004. Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone. Endocrinology, 145 7, 3232-8

Liu, Min; Shen, Ling; Liu, Yin; Woods, Stephen C; Seeley, Randy J; D'Alessio, David; Tso, Patrick 2004. Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus. American journal of physiology. Endocrinology and metabolism, 287 2, E366-70

Tso, Patrick; Liu, Min 2004. Apolipoprotein A-IV, food intake, and obesity. Physiology & behavior, 83 4, 631-43

Tso, Patrick; Liu, Min 2004. Ingested fat and satiety. Physiology & behavior, 81 2, 275-87

Tso, Patrick; Sun, William; Liu, Min 2004. Gastrointestinal satiety signals IV. Apolipoprotein A-IV. American journal of physiology. Gastrointestinal and liver physiology, 286 6, G885-90

Woods, Stephen C; D'Alessio, David A; Tso, Patrick; Rushing, Paul A; Clegg, Deborah J; Benoit, Stephen C; Gotoh, Koro; Liu, Min; Seeley, Randy J 2004. Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiology & behavior, 83 4, 573-8

Liu, Min; Doi, Takashi; Tso, Patrick 2003. Regulation of intestinal and hypothalamic apolipoprotein A-IV. Experimental biology and medicine (Maywood, N.J.), 228 10, 1181-9

Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick 2003. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, 78 1, 149-55

Liu, Min; Shen, Ling; Doi, Takashi; Woods, Stephen C; Seeley, Randy J; Tso, Patrick 2003. Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain research, 971 2, 232-8

Doi, T; Liu, M; Seeley, R J; Woods, S C; Tso, P 2001. Effect of leptin on intestinal apolipoprotein AIV in response to lipid feeding. American journal of physiology. Regulatory, integrative and comparative physiology, 281 3, R753-9

Liu, M; Doi, T; Shen, L; Woods, S C; Seeley, R J; Zheng, S; Jackman, A; Tso, P 2001. Intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology, 280 5, R1382-7

Tso, P; Liu, M; Kalogeris, T J; Thomson, A B 2001. The role of apolipoprotein A-IV in the regulation of food intake. Annual review of nutrition, 21 , 231-54

Liu, M; Shen, L; Tso, P 1999. The role of enterostatin and apolipoprotein AIV on the control of food intake. Neuropeptides, 33 5, 425-33

Tso, P; Liu, M; Kalogeris, T J 1999. The role of apolipoprotein A-IV in food intake regulation. The Journal of nutrition, 129 8, 1503-6

de Bari, Ornella; Wang, Tony Y; Liu, Min; Paik, Chang-Nyol; Portincasa, Piero; Wang, David Q-H . Cholesterol cholelithiasis in pregnant women: pathogenesis, prevention and treatment. Annals of hepatology, 13 6, 728-45