Kenneth Clark, Ph.D. Professor of Obstetrics and Gynecology Maternal-Fetal Medicine Email Telephone: 558-6552 Office Location: MSB5462

Education and Training:
B.S., 1969, Biology, Purdue University, Lafayette, Indiana
Ph.D., 1975, Cardiovascular Pharmacology, University of Iowa, Iowa City, Iowa
Fellowship, 1975-1976, Uterine physiology, University of Iowa, Iowa City, Iowa
Fellowship, 1976-1977, Uterine physiology, UCLA, Los Angeles, California

Recent Publications:
Lang U, Baker RS, Clark KE. Estrogen-induced increases in coronary blood flow are antagonized by inhibitors of nitric oxide. Eur J Obstet Reprod Biol. 1997; 74:229-235.
Zoma, WD, Baker RS, Clark KE. Coronary and uterine vascular responses to Raloxifene. Amer J Ob Gyn 2000; 182:521-528.
Clark KE, Baker RS, Lang U. Premarin-induced increases in coronary blood flow and uterine blood flow in the ovine. Amer J Ob Gyn 2000; 183:12-17, 2000.
Lang U, Baker RS, Clark KE. Effects of chronic reductions in uterine blood flow on ovine fetal growth. Amer J Physiol 2000; 279:R53-R59.
Zoma WD, Baker RS, Lang U, Clark KE. Hemodynamic response to tibolone in reproductive and nonreproductive tissues. Amer J Ob Gyn 2001; 184:544-551.

Scholarly Interests: Dr. Clarks laboratory conducts basic research on the mechanism of estrogen induced increases in uterine and coronary blood flow. They have isolated and cloned ovine estrogen receptor alpha and beta, ovine iNOS and ovine eNOS as well as ovine leptin. The second area of research focus has been the role that endothelin plays in regulating uterine and systemic vascular tone and it's potential role in preeclampsia. Finally, Dr. Clark has spent many years studying the effects of reduced uterine blood flow on fetal growth and resultant adaptation of the growth restricted fetus.

Fetal Cardiopulmonary Bypass: Dr. Clark is also involved with development of techniques at the Cincinnati Children’s Hospital to repair fetal hearts during pregnancy.

http://www.cincinnatichildrens.org/research/div/cardiothoracic/eghtesady

Program Director for the Interdisciplinary Women's Health Research Career Training Grant (BIRCWH), a multi-institutional NIH-funded program to enhance the research skills and expertise of basic scientist and clinical scientist beginning their faculty careers by providing three to five years of advanced research training in interdisciplinary approaches to women's health in the laboratory of a senior faculty mentor at the University of Cincinnati College of Medicine and the Cincinnati Children's Hospital Medical Center.