David F. Lewis, M.D., M.B.A Professor and Vice Chair of Obstetrics Director, Maternal-Fetal Medicine Fellowship Program Email david.lewis@uc.edu Phone: (513) 558-2038 Fax:     (513) 558-0494

David F. Lewis, M.D. finished medical school at Louisiana State University in 1985.  He finished his residency in Obstetrics and Gynecology at LSU Health Sciences Center in Shreveport, LA in 1989 and his fellowship in Maternal-Fetal Medicine at the University of California, Irvine in 1991.  He began his academic career back at LSU by starting Perinatal Services at that institution.  Over his 20 year career, he has been Residency Program Director at the University of Kentucky and Professor and Chairman of Obstetrics and Gynecology at Louisiana State University School of Medicine from 2002-2007.

Dr. Lewis joined the faculty at the University of Cincinnati in the Department of Obstetrics and Gynecology in November, 2007 as Professor and Vice Chair of Obstetrics and Director of the Maternal-Fetal Medicine Fellowship.

Credentials
BS: Biological Sciences, Louisiana State University 1981
MD: Louisiana State University 1985
MBA: Business Administration, University of Kentucky 2002
Residency: LSU Health Sciences Center 1985-1989
Fellowship: Maternal-Fetal Medicine, University of California, Irvine 1989-1991

Research

Dr. Lewis has been very active with research with over 90 Peer Review publications.  His interests include preterm, premature rupture of membranes, preeclampsia and prematurity.

Recent Publications

Lewis DF, Canzoneri BJ, Wang Y.  Maternal circulating TNF-α levels are highly correlated with IL-10 levels, but not IL-6 and IL-8 levels, in women with preeclampsia.  American Journal of Reproductive Immunology. 2009. In Press.

Elliott JP, Lewis DF, Morrison JC, Garite TJ. In Defense of Magnesium Sulfate.  Obstet Gynecol. 2009 June; 113(6): 1341-48.

Lewis DF, McCann J, Wang Y, Cormier C, Groome L.  Hospitalized late preterm mild preeclamptic patients with mature lung testing: what are the risks of delivery?  J Perinatol. 2009 Jan 22; 29: 413-5.

Habli M, Bombrys A, Lewis DF, Lim FY, Polzin W, Crombleholme T.  Prevalence of complications in twin twin transfusion syndrome following selective fetoscopic laser photocoagulation: a single center experience.  Am J Obstet Gynecol. 2008 Dec; 199(6): s177.

O’Brien JM, DeFranco EA, Adair CD, Lewis DF, Hall DR, How H, Bsharat M, Creasy, GW.  The effect of progesterone on the rate of cervical shortening in women at risk for preterm birth.  J Perinatol. Submitted.

Canzoneri BJ, Lewis DF, Groome L, Wang Y. Increased neutrophil numbers account for leukocytosis in women with preeclampsia. Am J Perinatol. 2009 May 18. In print. 

Gu Y, Lewis DF, Alexander JS, Wang Y.  Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia. Reprod Sci. 2009 May; 16(5):479-88.

Rahman S, Abdul-Waheed M, Helmy T, Huffman LC, Koshal V, Guitron J, Merrill WH, Lewis DF, et. al.  Spontaneous left main coronary artery dissection complicated by pseudoaneurysm formation in pregnancy: role of CT coronary angiography.  J Cardiothorac Surg. 2009 Apr 1; 4:15.

Wang Y, Lewis DF, Adair CD, Gu Y, Mason L, Kipikasa, JH.  Digibind attenuates cytokine TNFalpha-induced endothelial inflammatory response: potential benefit role of Digibind in preeclampsia. J Perinatol.  2009 Mar; 29(3):195-200.

O’Brien JM, Lewis DF.  Progestins for the prevention of spontaneous preterm birth: review and implications of recent studies.  J Repro Medicine. 2009 Feb; 54(2):73-87.

Masood SA, Sangster G, Chen E, Tice H, Julian KC, Lewis DF, Ibrahim H.  Agnathia-Otocephaly.  Journal La State Med Soc.  2008 Nov/Dec; 160(6): 325-327.

Wang Y, Gu Y, Lewis DF.  Endothelial angiotensin II generation induced by placenta-derived factors from preeclampsia.  Reprod Sci.  2008 Nov; 15(9):932-8.

Gu Y, Lewis DF, Deere K, Groome LJ, Wang Y.  Elevated maternal IL-16 levels, enhanced IL-16 expressions in endothelium and leukocytes, and increased IL-16 production by placental trophoblasts in women with preeclampsia.  J Immunol. 2008 Sep 15;181(6) 4418-22.

Zhang J, Masciocchi M, Lewis DF, Sun W, Liu A, Wang Y.  Placental antioxidante gene polymorphisms, enzyme activity, and oxidative stress in preclampsia.  Placenta. 2008 May; 29(5):439-43.

Chico M, Levine SN, Lewis DF.  Normoglycemic diabetic ketoacidosis in pregnancy.  J Perinatol. 2008 Apr; 28(4):310-2.

Wang Y, Zhang Y, Canzoneri BJ, Gu Y, Philibert L, Lewis DF.  Prostacyclin and thromboxane levels in women with severe preeclampsia undergoing magnesium sulfate therapy during antepartum and postpartum periods.  Hypertens Pregnancy. 2008; 27(1): 17-27.

Gu Y, Lewis DF, Wang Y.  Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies.  J Clin Endocrinol Metab. 2008 Jan; 93(1) 260-6.

Zhao S, Gu Y, Lewis DF, Wang Y.  Predominant basal directional release of thromboxane, but not prostacyclin, by placental trophoblasts from normal and preeclamptic pregnancies.  Placenta. 2008 Jan; 29(1):81-8.

DeFranco EA, O’Brien JM, Adair CD, Lewis DF, et al.  Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double-blind, placebo-controlled trial.  Ultra Obstet Gynecol. 2007 Oct; 30(5):697-705.

O’Brien JM, Adair CD, Lewis DF, Hall DR, et al.  Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized, double-blind, placebo-controlled trial.  Ultra Obstet Gynecol. 2007 Oct; 30(5):687-696.

Wang Y, Gu Y, Lewis DF.  Gene expresión profiles in leukocytes from women with normal pregnancy and preeclampsia.  Submitted, Am J Obstet Gynecol, 2007.

Barrilleaux PS, Magann EF, Chauhan SP, York BM, Philibert L, Lewis DF.  Amniotic fluid index as a predictor of adverse perinatal outcome in the HELLP syndrome.  J Reprod Med. 2007; 52(4):293-8.

Ibrahim H, Lewis D, Harrison GK, Tice H, Sangster G.  Congenital ovarian cyst.  J Perinat. 2007 Aug; 27(8): 523-26.

Wang Y, Gu Y, Zhang Y, Lewis DF, Alexander JS, Granger DN. Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia. Placenta. 2007 Apr; 28(4):263-269.

Wang Y, Lewis DF, Zhang Y, et. Al.  Enhanced P-selectin immunoreactivity in the maternal vessel endothelium and elevated plasma soluble P-selectin levels in women with preeclampsia. Submitted  NCEM January, 2007.

Lewis DF, Robichaux AG, Jaekle FK, Salas A, Canzoneri BJ, Horton K, Jaekle L, Stedman C.  Expectant management of preterm premature rupture of membranes and nonvertex presentation: what are the risks?  Am J Obstet Gynecol 2007June;196(6):566.e1-5; discussion 566.e5-6.

Wang Y, Lewis DF, Alexander SJ, Grangier DN. Endothelial barrier function in preeclampsia. Front Biosci. 2007 Jan 1; 12:2412-24.