Professor of Neurology
Chairman, Department of Neurology
Director, Greater Cincinnati/Northern Kentucky Stroke Team
Medical Education: University of Cincinnati College of Medicine, 1982
Residency Training: Mayo Clinic, 1982-1985
Fellowship Training: Mayo Clinic (Cerebrovascular Disease), 1986-1987
Board Certification: Neurology
Clinical Interests: All facets of treatment of stroke
Research Interests: Treatment of acute stroke, epidemiology and genetics of both ischemic and hemorrhagic stroke
Selected Publications:
Please click here for the National Library of Medicine's link to Dr. Broderick's publications.
Broderick JP, Phillips S, O'Fallon WM, Whisnant JP:
Relationship of cardiac disease to stroke occurrence, recurrence and mortality.
Stroke 23:1250-1256, 1992.
Broderick J, Brott T, Tomsick T, Huster G, Miller R: The risk of
subarachnoid and intracerebral hemorrhages in blacks as compared with whites.
N Engl J Med 326:733- 736, 1992.
Ezekowitz MD, Bridgers SL, James KE, et. al: Study of stroke
prevention in nonrheumatic atrial fibrillation (SPINAF). N Engl J Med
327:1406-12, 1992.
Brott T, Haley EC, Levy DE, Barsan W, Broderick J, Sheppard G,
Spilker J, Kongable G, Reed R, Marler J: Urgent therapy for stroke: pilot
study of tissue plasminogen activator administered within 90 minutes. Stroke
23:632-640, 1992.
Tomsick T, Brott T, Barsan W, Broderick J, Haley EC, Levy DE,
Sheppard G, Spilker J: Thrombus localization with emergency cerebral computed
tomography. AJNR 13:257- 263, 1992.
Broderick JP, Brott T, Tomsick T, Miller R, Huster G:
Intracerebral hemorrhage is more than twice as common as subarachnoid
hemorrhage. J Neurosurg 78(2):188-191, 1993.
Broderick J, Brott T, Tomsick T, Huster G: Lobar
Hemorrhage in the Elderly: The undiminishing importance of hypertension. Stroke
24(1):49-51, 1993.
Broderick J, Brott T, Miller R: Intracranial hemorrhage in
Blacks as compared with Whites. In: Letters to the Editor, N Engl J Med 327(8):568,
1993.
Broderick JP, Talbot GT, Prenger E, Leach A, Brott T:
Stroke in children within a major metropolitan area: The surprising
importance of intracerebral hemorrhage. J Child Neurol 8:250-255,
1993.
Broderick J, Brott T, Barsan W, Haley C, Levy D, Marler J, Blum
C: Blood pressure during the first minutes of focal cerebral ischemia.
Ann Emerg Med 22:1438-1443, 1993.
Haley EC, Brott TG, Sheppard GI, Barsan W, Broderick J, Marler
JR, Kongable GL, Spilker J, Massey S, Hansen CA, Torner JC: Pilot randomized
trial of tissue plasminogen activator in acute ischemic stroke. Stroke
24:1000-1004, 1993.
Broderick JP, Brott TG, Duldner JE, Tomsick T, Huster G: Volume
of intracerebral hemorrhage: a powerful and easy-to-use predictor of 30-day
mortality. Stroke 24:987- 993, 1993.
Barsen WG, Brott TG, Broderick JP, Haley EC, Levy DE, Marler JR:
Time of hospital presentation in patients with acute stroke. Arch Int
Med 153: 2558-2561, 1993.
Levy DE, Brott TG, Haley EC, Marler JR, Sheppard GL, Barsan W,
Broderick JP: Factors related to intracranial hematoma formation in patients
receiving t-pa for acute, ischemic stroke. Stroke 25:291-297, 1994.
Brott T, Tomsick T, Feinberg W, Johnson C, Biller J, Broderick
J, Kelly M, Frey J, Schwartz S, Blum C, Nelson JJ, Chambless L, Toole J:
Baseline silent cerebral infarction in the asymptomatic carotid atherosclerosis
study. Stroke 25: 1122-1129, 1994.
Broderick J, Brott T. Response to Letter to the Editor:
Prediction of outcomes after intracerebral hemorrhage. Stroke
24:11; 1761, 1993.
Broderick J, Brott T, Tomsick T, Tew J, Duldner J, Huster G.
Management of intracerebral hemorrhage in a large metropolitan population.
Neurosurgery 34:882-887, 1994.
Broderick JP, Grott JC, Brott TG. Letter to the Editor.
Intracerebral hemorrhage volume measurement. Stroke 25:1081, 1994.
Broderick J, Brott T, Duldner J, Tomsick T, Leach A: Initial and
recurrent bleeding are the major causes of death following subarachnoid
hemorrhage. Stroke 25:1342-1347, 1994.
The Ancrod Study Group Investigators: Ancrod for the
treatment of acute ischemic brain infarction. Stroke
25:1755-1759, 1994.
O'Brien GM, Baughman RP, Broderick JP, Arnold L, Lower EE:
Paranoid psychosis due to neurosarcoidosis. Sarcoidosis 11:34-36,
1994.
Barsan WG, Brott TG, Broderick JP, Haley EC, Levy DE, Marler JR:
Urgent therapy for acute stroke effects of a stroke trial on untreated patients.
Stroke 25:2132-2137, 1994.
Broderick J, Hagen T, Brott T, Tomsick T: Hyperglycemia and
hemorrhagic transformation of cerebral infarcts. Stroke 26:484-487,
1995.
Lyden P, Brott T, Tilley B, et al: Improved reliability of
the NIH stroke scale using video training. Stroke 25:2220-2226,
1994.
Kothari R, Barsan W, Brott T, Broderick J, Ashbrock S: The
potential of prehospital care providers to impact early treatment in acute
stroke: a pilot study. Stroke 26:937- 941, 1995.
The NINDS t-PA Stroke Trial Investigators: Ultra-early
administration of rt-PA in acute ischemic stroke within 3 hours of onset. NEJM
333:1581-1587, 1995.
Arata L, Dhawan A, Broderick J, Gaskill M, Levy A, Volkow N.
Three-dimensional anatomical based segmentation of MR brain images through
principle axes registration. IEEE Transactions on Biomed Eng.
42(11):1069-1078, 1995.
Executive Committee for ACAS. Endarterectomy for
asymptomatic carotid artery stenosis. JAMA 273:1421-1428,
1995.
Loncaric S, Dhawan AP, Broderick J, Brott. 3D Image
analysis of intracerebral brain hemorrhage from digitized CT films. Computer
Methods and Programs in Biomedicine 46:207-216,
1995.
Ezekowitz MD, James KE, Nazarian SM, Yen R, Broderick JP,
Davenport J, Gupta SR, Thadani V, Meyers ML, Bridgers SL for the Veterans
Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators:
Silent cerebral infarction in patients with nonrheumatic atrial
fibrillation. Circulation 92:2178-2182, 1995.
Kothari RU, Brott TG, Broderick JP, Hamilton CA. Emergency
Physicians: Accuracy in the diagnosis of stroke. Stroke
26:2238-2241, 1995.
Tomsick T, Brott T, Barsan W, Broderick J, Haley EC, Spilker J,
Khoury J: Prognostic value of the hyperdense middle cerebral artery sign and
stroke scale score before ultra early thrombolytic therapy. AJNR
17:1-7, 1996.
Broderick J, Narayan S, Gaskill M, Dhawan A, Chou C:
Volumetric measurement of multi-focal brain lesions: Implications for treatment
trials of vascular dementia and multiple sclerosis. Journal of
Neuroimaging 1:36-43, 1996.
Wagner KR, Xi G, Hua Y, Kleinholz M, de Courten-Myers G, Myers
RE, Broderick JP, Brott TG: Lobar intracerebral hemorrhage model in pigs:
Rapid edema development in perihematomal white matter. Stroke
27:490-497, 1996.
Kothari RU, Brott T, Broderick JP, Barsan WG, Sauerbeck LR,
Zuccarello M, Khoury J. The ABC's of measuring intracerebral hemorrhage
volumes. Stroke 27:1304-1305, 1996.
Brott T, Broderick J, Barsan W, Kothari R, Tomsick T, Spilker J,
Khoury J. (Corresponding author - J. Broderick). Continued bleeding during
the first hours of intracerebral hemorrhage. Stroke 28:1-5,
1997.
Young B, Moore W, Robertson J, Toole J, Ernst C, Cohen S,
Broderick J, Dempsey R, Hosking J, and the ACAS Investigators. An analysis
of the perioperative surgical mortality and morbidity of the Asymptomatic
Carotid Atherosclerosis Study. Stroke, 27:2216-2224, 1996.
Kothari R, Hall K, Broderick J, Brott T. Early stroke
recognition: a prehospital stroke scale. Stroke 27:171, 1996.
Kothari R, Pancioli A, Brott T, Broderick J. Thrombolytic
therapy for cerebral infarction. Academic Emergency Medicine
3:881-892, 1996.
Tilley B, Lyden P, Brott T, Levine S, Welch KMA and the NINDS rt-PA
Stroke Study Group. Total quality improvement methodology reduces delays
between emergency department admission and treatment of acute ischemic stroke.
Archives of Neurology, 54:1466-1474, 1997.
NINDS rt-PA Stroke Trial Investigators and Coordinators. A
systems approach to immediate evaluation and management of hyperacute stroke:
Experience at 8 centers and implications for community practice and patient
care. Stroke 28:1530-1540, 1997.
Schwartz S, Chambless L, Baker WH, Broderick JP, Howard G.
Consistency of Doppler parameters in predicting carotid stenosis. Stroke
28(2):343-347, 1997.
Lower EE, Broderick JP, Brott T, Baughman RP. Diagnosis
and management of neurologic sarcoidosis. Archives of Internal
Medicine 157:1864-1868, 1997.
Howard G, Baker WH, Chambless LE, Howard VJ, Jones AM, Toole JF,
for the Asymptomatic Carotid Atherosclerosis Study Investigators. An
approach for the use of Doppler ultrasound as a screening tool for
hemodynamically significant stenosis despite heterogeneity of Doppler
performance. Stroke 27:1951-1957, 1996.
NINDS t-PA Acute Stroke Investigators. Generalized
efficacy of t-PA for acute stroke: Subgroup analysis of the NINDS t-PA stroke
study. Stroke 28:2119-2125, 1997.
NINDS t-PA Stroke Study Group (J. Broderick - corresponding
author). t-PA and the risk of intracerebral hemorrhage inpatients with
ischemic stroke: The NINDS t-PA Stroke Study. Stroke 28:2109-2118,
1997.
Fagan S, Morgenstern L, Petitta A, Ward R, Tilley B, Marler JR,
Levine S, Broderick J, Kwiatkowski T, Frankel M, Walker M and the NINDS rt-PA
Stroke Study Group. Cost- effectiveness of tissue plasminogen activator
for acute ischemic stroke. Neurology, 50(4):883-890.
Broderick J, Brott T, Kothari R, Miller R, Khoury J, Pancioli A,
Tomsick T, Mills D, Minneci L, Shukla R. The Greater Cincinnati/ Northern
Kentucky Stroke Study: preliminary first-ever total incidence rates of stroke
among blacks. Stroke 29:415-421, 1998.
Stroke Outcome Measurement Task Force. American Heart
Association stroke outcome classification. Stroke 29:1272-1273,
1998
Pancioli A, Broderick J, Kothari R, Brott T, Tuchfarber A,
Miller R, Khoury J. Public perception of stroke warning signs and
potential risk factors. JAMA, 279(16):1288- 1292.
Kothari R, Sauerbeck L, Jauch E, Broderick J, Brott T, Khoury J,
Liu T. Patients' awareness of stroke signs, symptoms and risk factors.
Stroke 28:1871-1875, 1997.
Haley EC Jr, Lewandowski C, Tilley B, and the NINDS rt-PA Stroke
Study Group. Myths regarding the NINDS rt-PA Stroke Trial: Setting the
record straight. Annals of Emergency Medicine
30:676-682;1997.
Broderick JP. Logistics in acute stroke management. Drugs
54:109-116, 1997.
Bettmann MA, Katzen BT, Whisnant J, Brant-Zawadzki M, Broderick
JP, Furlan AJ, Hershey LA, Howard V, Kuntz R, Loftus CM, Pearce W, Roberts A,
Roubin G. Carotid stenting and angioplasty. Stroke
29:336-348, 1998.
Brott T, Lu M, Fagan SC, Frankel M, Grotta JC, Broderick JP,
Kwiatkowski T, Lewandowski C, Haley EC, Jr., Marler JR, Tilley BC, and the NINDS
rt-PA Stroke Study Group. Hypertension and its treatment in the NINDS rt-PA
Stroke Trial. Stroke 29:1504-1509, 1998.
The International Study of Unruptured Intracranial Aneurysms
Investigators: Unruptured intracranial aneurysms - risks of rupture and risks of
surgical intervention. N Engl J Med 339:1725-33, 1998.
Guohua G, Wagner KR, Keep RF, Hua Y, de Courten-Myers GM,
Broderick JP, Brott TG, Hoff JT. Role of blood clot formation on early
edema development after experimental intracerebral hemorrhage. Stroke
29:2580-2586, 1998.
Gorelick PB, Leurgans S, Richardson D, Harris Y, Billingsley M,
and the AAASPS Investigators. African-American Antiplatelet Stroke
Prevention Study (AAASPS): Clinical Trial Design," J. Stroke and
Cerebrovascular Diseases, in press.
Wagner KR, Guohua X, Hua Y, Zuccarello, de Courten-Myers GM,
Broderick JP, Brott TG. Ultra-early clot aspiration after lysis with
tissue plasminogen activator in a porcine model of intracerebral hemorrhage:
edema reduction and blood brain barrier protection. J of Neurosurgery
90:491-498, 1999.
Kothari RU, Pancioli A, Liu T, Brott T, Broderick J:
Cincinnati Prehospital Stroke Scale: Reproducibility and Validity. Annal
of Emerg Med 33:4;373-378, 1999.
Kwiatkowski T, Libman R, Frankel M, Tilley B, Morgenstern L, Lu
M, Broderick JP, Marler J, Brott T and the NINDS rt-PA Stroke Study Group.
Effects of tissue plasminogen activator for acute ischemic stroke at one year.
N Engl J Med 1999;340:1781-1787.
Zuccarello M, Brott T, Derex L, Tew J, van Loveren H, Yeh HS,
Tomsick T, Kothari R, Pancioli A, Khoury J, Sauerbeck L, Broderick JP
(corresponding author). Early surgical treatment for supratentorial
intracerebral hemorrhage. A randomized feasibility study. Stroke
1999;30:1833-1839.
Grotta J, Chiu D, Lu M, Patel S, Levine S, Tilley B, Brott T,
Haley C, Lyden P, Kothari R, Frankel M, Lewandowski C, Libman R, Marler J,
Kwiatkowski T, Huff S for the NINDS rt-PA Stroke Study Group. Agreement
and variability in the interpretation of early CT changes in stroke patients
qualifying for intravenous rt-PA therapy. Stroke 1999;30:1528-1533.
Lyden PD, Lu M, Jackson CM, Marler J, Kothari R, Brott T, Zivin
J, and the NINDS t-PA Stroke Trial Investigators. Underlying structure of
the National Institutes of Health Stroke Scale. Results of a factor
analysis. Stroke 1999;30:2347-2354.
Woo D, Broderick J, Kothari R, Lu M, Brott T, Lyden P, Marler J,
Grotta J, Tilley B and the NINDS t-PA Stroke Study Group. Does the NIHSS
favor left hemisphere strokes? Stroke 1999;30:2355-2359.
Broderick J, Gaskill M, Dhawan A, Khoury J. Temporal
changes in brain volume and cognition in a randomized treatment trial of
vascular dementia. Journal of Cerebrovascular Disease,
In Press.
Marler J, Tilley B, Lu M, Broderick J, Brott T, Lyden P, Grotta
J, Levine S, Frankel M, Horowitz S, Haley C, Kwiatkowski T for the NINDS rt-PA
Stroke Study Group. Earlier treatment associated with better outcome: the NINDS
t-PA Stroke Study. Neurology 2000;55:1649-1655.
Broderick J, Adams HP, Barsan W, Feinberg W, Feldmann E, Grotta
J, Kase C, Kreiger D, Mayberg M, Tilley B, Zabramski J, Zuccarello M.
Guidelines for the management of spontaneous intracerebral hemorrhage. A
statement for healthcare professionals from a special writing group of the
Stroke Council, American Heart Association. Stroke 1999;30:905-915.
Wagner KR, Bryan DW, Hall CL, et al. White matter injury
after intracerebral hemorrhage: Infused plasma but not red blood cells induces
early DNA fragmentation. J. Cereb. Blood Flow Metab.19 (Suppl.
1):S55, 1999.
Woo D, Gebel J, Miller R, Kothari R, Brott T, Khoury J,
Salisbury S, Shukla R, Pancioli A, Broderick J. Incidence rates of
first-ever ischemic stroke subtypes among blacks: a population-based study.
Stroke 1999;30:2517-2522.
Lewandowski CA, Frankel M, Tomsick T, Broderick J, Frey J, Clark
W, Starkman S, Grotta J, Spilker J, Khoury J, Brott T and the EMS Bridging Trial
Investigators. Combined intravenous and intra-arterial rt-PA versus
intra-arterial therapy of acute ischemic stroke. Emergency Management of
Stroke (EMS) Bridging Trial. Stroke 1999;30:2598-2605.
Wagner KR, Hua Y, De Courten-Meyers G, Broderick J, Nishimura
RN, Lu S-Y, Dwyer BE. TIN-Mesoporohyrin, a potent heme oxygenase
inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro
studies. Cellular and Molecular Biology 2000;46(3),
597-608.
Albers G, Alberts M, Broderick J, Lyden P, Sacco R: Recent
advances in stroke medicine. J of Stroke and Cerebrovasc
Dis 2000;9:95-105.
Kissela B, Broderick, J. Management of hyperlipidemia and
stroke. The Neurologist, 1999, In Press.
Laurent Derex, MD, Thomas Tomsick, MD, Thomas Brott, MD,
Christopher Lewandowski, MD; Michael Frankel, MD; Wayne Clark, MD, Sid Starkman,
MD, Judith Spilker, RN, Gavin Udsten, MD, Jane Khoury, MS, James Grotta, MD,
Joseph Broderick, MD for the EMS Bridging Trial Investigators. Outcome of stroke
patients without angiographic arterial occlusion. Stroke, In Press.
Broderick JP, Lu M, Kothari R, Levine S, Lyden P, Haley C, Brott
T, Grotta J, Tilley BC, Marler JR, and the NINDS t-PA Stroke Study
Investigators. Finding the most powerful measures of t-PA’s effectiveness in
the NINDS t-PA Stroke Trial. Stroke 2000;31:2335-2341.
NINDS rt-PA Stroke Study Group. Effect of intravenous rt-PA
on ischemic stroke lesion size measured by computerized tomography: results from
the NINDS rt-PA Stroke Trial. Stroke, 2000 31:2912-2919.
Frankel M, Morgenstern L, Kwiatkowski T, Lu M, Tilley B,
Broderick J, Libman R, Levine S, Brott T, and the NINDS rt-PA Stroke Trial
Investigators. Predicting prognosis after stroke: A placebo group analysis
from the NINDS rt-PA Stroke Trial. Neurology, 2000;55:952-959.
Grotta JC, Welch KMA, Fagan S, Lu M, Frankel M, Brott T, Levine
SR, Lyden P, and the NINDS rt-PA Stroke Study Group. Clinical Deterioration
Following Improvement in the NINDS rt-PA Stroke Trial. In press, Stroke,
2000
Joseph Broderick, MD, Mei Liu, Christy Jackson, MD, Arthur
Pancioli, MD, Barbara C. Tilley, PhD, Susan C. Fagan, Pharm D, Rashmi
Kothari , MD, Steven R. Levine , MD, John R. Marler, MD, Patrick D. Lyden,
MD , E. Clark Haley, Jr., MD, Thomas Brott, MD, James C. Grotta, MD and the
NINDS t-PA Study Group. Apolipoprotein E Phenotype and the Efficacy of
Intravenous Tissue Plasminogen Activator in Acute Ischemic Stroke. Ann
Neurol 2001;49:736-744.
Kissela B, Broderick J, Woo D, Kothari R, Miller R, Khoury J,
Brott T, Pancioli A, Jauch E, Gebel J, Shukla R, Alwell K, Tomsick T. Greater
Cincinnati/Northern Kentucky Stroke Study: Volume of first-ever ischemic
stroke among blacks in a population-based study. Stroke
2001;32:1285-1290
Lyden PD, Lu M, Levine S, Brott T, Broderick J and the NINDS rt-PA
Stroke Study Group. A modified National Institutes of Health stroke scale
for use in stroke clinical trials. Preliminary reliability and validity. Stroke.
2001;32:1310-1317.
Qureshi A, Tuhrim S, Broderick J,Batjer Hunt H, Hondo H, Hanley
D. Spontaneous Intracerebral Hemorrhage. N Engl J Med.
Vol. 344, No. 19;1450-1460. May, 2001.
Kissela BM, Kothari RU, Tomsick TA, Woo D, Broderick J:
Embolization of calcific thrombi after tissue plasminogen activator treatment.
Journal of Stroke and Cerebrovascular Disease 10:3, 135-138, 2001
Clark JF, Pyne GJ, Choutka OJ, Carrozzella JA, Khoury J,
Broderick JP, Cadoux-Hudson TAD. Experimental Research: In vitro therapy
with dobutamine, isoprenaline and sodium nitroprusside protects vascular smooth
muscle metabolism from subarachnoid haemorrhage induces cerebral vasospasm.
Acta Neurochir (Wien) 143:721-728, 2001.
Fisher M, Broderick J. Recommendation for clinical trial
evaluatin of acute stroke therapies. Accepted Stroke, 2001.
Lu M, Tilley BC for the NINDS t-PA Stroke Trial Study Group.
Use of odds ratio or relative risk to measure a treatment effect in clinical
trials with multiple correlated binary outcomes: Data from the NINDS t-PA Stroke
Trial. In preparation.
Szaflarski J, Broderick JP (corresponding author), Brott T.
Who gets paid what for the care of stroke patients? (In preparation).
Lyden P, Lu M, Kwiatkowski T, Frankel M, Levine S, Broderick J,
Brott T, and NINDS rt-PA Stroke Study Group. Thrombolysis in patients with
transient neurological deficits.Submitted Neurology, 2001.
Broderick J, Brott T, Tomsick T, Tew J, Duldner J, Huster G. "Management of intracerebral hemorrhage in a large metropolitan population." Neurosurgery, 1994;34:882-887.