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Metals at EB2009
Experimental Biology at New Orleans, Louisiana, April 18–22, 2009 featured the following sessions on the transport and metabolism of iron and other transition metal ions including copper and zinc. These sessions were sponsored by the American Physiological Society (APS) and the American Society for Nutrition (ASN).
Meeting Abstracts
APS Poster Session: Hepcidin and Iron Homeostasis
APS Poster Session: Metal-Ion Transport
ASN Minisymposium: Iron I
ASN Minisymposium: Impact of Diet and Genetics on Copper-Dependent Functions
ASN Minisymposium: Zinc I
ASN Poster Session: Iron II
ASN Poster Session: Diet and Endocrine Effects on Copper Biology
ASN Poster Session: Zinc II
Other Scientific Presentations of Interest: Sunday, April 19 • Monday, April 20 • Tuesday, April 21
APS GI & Liver Section Banquet
Travel Awards
Upcoming Meetings
Positions Available
Sunday, April 19
ASN Minisymposium: Iron I
Sunday, April 19
10:30 am – 12:30 pm
Ernest N Morial Convention Center, Room 340/341
| Chair: | Okhee Han, Pennsylvania State University, University Park, PA | |
| Time | Program # | Title, Authors and Affiliations |
| 10:30 am | Overview Okhee Han Pennsylvania State University, University Park, PA |
|
| 10:45 am | 105.1 | Selected trace metals inhibit transepithelial non-heme iron transport by inhibiting the basolateral iron exit in human intestinal cells |
| 11:00 am | 105.2 | Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by iron James F Collins1, Y Lu1, L Xie2, P N Ranganathan1 1University of Florida, Gainesville, FL; 2University at Buffalo–SUNY, Buffalo, NY |
| 11:15 am | 105.3 | Subcellular localization of the metal-ion transporters Zip14 and DMT1 in human hepatoma (HepG2) cells Ningning Zhao, Mitchell D Knutson University of Florida, Gainesville, FL |
| 11:30 am | 105.4 | Potential abnormalities in iron metabolism in hyperlipidemia patient fibroblasts Chevaun Morrison1, Eric N Sauble1, Annie Nguyen1, Alice La1, Gideon Bach2, Maria C Linder1 1California State University, Fullerton, CA; 2Hadassah Medical Center, Jerusalem, Israel |
| 11:45 am | 105.5 | Investigations of iron, hypoxia and adipocyte hypoxia on hepcidin promoter activity Korry Joseph Hintze, Darren Nabor, Hunter Timbimboo, Dallin Snow Utah State University, Logan, UT |
| 12:00 pm | 105.6 | BXD strains of mice exhibit diurnal fluctuations in brain and liver iron and iron management proteins Erica L Unger1, Lei Hao1, Christopher J Earley2, John L Beard1 1Pennsylvania State University, University Park, PA; 2Johns Hopkins University, Baltimore, MD |
| 12:15 pm | 105.7 | Role of maternal/fetal iron status on placental transferrin receptor expression Melissa Fox Young1, Marisa Foehr1, Thomas McNanley2, Elizabeth Cooper2, Eva Pressman2, Ronnie Guillet2, Mark Orlando2, Allison McIntyre2, Julie Lafond3, Kimberly O O'Brien1 1Cornell University, Ithica, NY; 2University of Rochester–SUNY, Rochester, NY; 3University of Quebec, Montreal, Canada |
Other Scientific Presentations of Interest—Sunday, April 19
ASBMB Poster Session: Structural Enzymology
Sunday, April 19
1:00 pm – 2:05 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 504.2 | C123 | Ferritin-specific diiron ligands control Fe/O2 chemistry in iron
mineralization; diiron substrate vs diiron oxygenases Elizabeth C Theil1,2, Takehiko Tosha1, Mohammad R Hasan1 1Children's Hospital Oakland Research Institute, Oakland, CA; 2University of California–Berkeley, Berkeley, CA |
APS Poster Session: Renal Ion Transport, Trafficking and Regulation
Sunday, April 19
12:45 pm – 3:00 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 602.15 | D164 | Role of ferroportin-1 (FPN-1) in iron (Fe) handling by the
kidney proximal tubule (PT) |
Monday, April 20
ASN Minisymposium: Zinc I
Monday, April 20
8:00 am – 10:00 am
Ernest N Morial Convention Center, Room 340/341
| Co-Chairs: | James P McClung, US Army Research Institute of Environmental Medicine, Natick, MA Shannon L Kelleher, Pennsylvania State University, University Park, PA |
| Time | Program # | Title, Authors and Affiliations |
| 8:00 am | 216.1 | Zinc status affects DNA damage and oxidative stress in healthy adult men Yang Song1, Carolyn S Chung2, Richard S Bruno3, Maret G Traber1, Kenneth H Brown4, Janet C King2,4 1Oregon State University, Portland, OR; 2Children’s Hospital Oakland Research Institute, Oakland, CA; 3University of Connecticut, Farmington, CT; 4University of California–Davis, Davis, CA |
| 8:15 am | 216.2 | Effects of altered zinc availability on proliferation and oxidative stress in cultured cells
Kavitha Sankavaram, Bruce J Grattan, Robin Walker, Hea Jin Park, Hedley C Freake University of Connecticut, Storrs, CT |
| 8:30 am | 216.3 | Zip6 attenuation reduces intracellular zinc pools and potentiates oncogenesis in T47D cells Veronica Lopez, Shannon L Kelleher Pennsylvania State University, University Park, PA |
| 8:45 am | 216.4 | Dual-localization of ZnT2 to mitochondria and exocytotic vesicles redistributes zinc pools in mammary cells Young Ah Seo, Shannon L Kelleher Pennsylvania State University, University Park, PA |
| 9:00 am | 216.5 | Zinc-regulated ZnT1 (SLC30A1) and glucocorticoid-regulated ZnT2 (SLC30A2) influence zinc efflux from pancreatic acinar cells Liang Guo, Robert J Cousins University of Florida, Gainesville, FL |
| 9:15 am | 216.6 | Effects of zinc supplementation on growth of children under 5 years of age: A meta analysis of randomized controlled trials Phuong Nguyen, Usha Ramakrishnan, Reynaldo Martorell Emory University, Atlanta, GA |
| 9:30 am | 216.7 | Iron and zinc deficiencies affect zinc kinetic parameters in rats Katsuhiko Yokoi1, Aki Konomi1,2 1Seitoku University, Chiba, Japan; 2University of Shizuoka, Shizouka, Japan |
| 9:45 am | 216.8 | Relationship between endogenous fecal zinc and zinc absorbed revisited K Michael Hambidge, Leland V Miller, Nancy F Krebs University of Colorado–Denver, Aurora, CO |
ASN Poster Session: Diet and Endocrine Effects on Copper Biology
Monday, April 20
(I) 12:45 pm – 1:45 pm
(II) 1:45 pm – 2:45 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 727.1 (I) | B152 | Oxidative stress in cardiac mitochondria caused by copper deficiency may be insufficient to damage mitochondrial proteins |
| 727.2 (II) | B153 | Dietary copper deficiency up-regulates selected cardiac copper chaperone proteins |
| 727.3 (I) | B154 | Tempol normalizes aortic relaxation but not elevated isoprostanes or PGE2 in copper-deficient rats Dale Schuschke1, W Thomas Johnson2, Ayotunde Adeagbo1 1University of Louisville, Louisville, KY; 2ARS, USDA, Grand Forks, ND |
| 727.4 (II) | B155 | Forms of copper secreted by human mammary epithelial cells in response to lactational hormones Maricruz Rivera1, Stephen Kim1, Sara Le Van1, Albert Beck1, Ben Rojas1, Agnes Michalczyk1, Leigh Ackland2, Andrew Z Mason3, Maria C Linder1 1California State University, Fullerton, CA; 2Deakin University, Burwood, Australia; 3California State University, Long Beach, CA |
| 727.5 (I) | B156 | Copper distribution and incorporation into ceruloplasmin and other plasma proteins in mice overexpressing ATP7A Yu-Hsiang Chu1, Tiffinie Ho1, Roxana Llanos1, Julian Mercer2, Maria C Linder1 1California State University, Fullerton, CA; 2Deakin University, Burwood, Australia |
ASN Minisymposium: Impact of Diet and Genetics on Copper-Dependent Functions
Monday, April 20
3:00 – 5:00 pm
Ernest N Morial Convention Center, Room 340/341
| Chair: | Joseph R Prohaska, University of Minnesota Medical School, Duluth, MN | |
| Co-Chair: | Janet Y Uriu-Adams, University of California–Davis, Davis, CA | |
| Time | Program # | Title, Authors and Affiliations |
| 3:00 pm | Overview Joseph R Prohaska University of Minnesota Medical School, Duluth, MN |
|
| 3:15 pm | 231.1 | Moderate copper deficiency affects liver metallothionein and resistance to chemical hepatotoxicity |
| 3:30 pm | 231.2 | Knockout of SOD1 decreased GPX1 activity but not GPX1 protein in murine liver Shikui Wang, X G Lei Cornell University, Ithaca, NY |
| 3:45 pm | 231.3 | Role of copper transport system for extracellular superoxide dismutase in angiotensin II-induced hypertension Tohru Fukai, Kiyoshi Ozumi, Ha Won Kim, Ronald D McKinney, Masuko Ushio-Fukai University of Illinois–Chicago, Chicago, IL |
| 4:00 pm | 231.4 | Age-related changes in tissue copper (Cu) and iron (Fe) levels in the Ctr-1 mouse Rachel Erin Scherr, Michael Chew, Anh Le, Carl L Keen, Janet Y Uriu-Adams University of California–Davis, Davis, CA |
| 4:15 pm | 231.5 | Variations in dietary copper alter physiological and behavioral function Danielle Bousquet-Moore1, Betty Eipper1, Joseph R Prohaska2, Richard Mains1 1University of Connecticut Health Center, Farmington, CT; 2University of Minnesota Medical School, Duluth, MN |
| 4:30 pm | 231.6 | Copper deficiency increases ferroportin expression in rats |
| 4:45 pm | 231.7 | In vivo protein NMR spectroscopy reveals an altered neurochemical profile in copper deficient rat brain Joseph R Prohaska, Anna Gybina University of Minnesota Medical School, Duluth, MN |
Other Scientific Presentations of Interest—Monday, April 20
ASBMB Poster Session: Biophysical Methods
Monday, April 20
1:00 pm – 2:05 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 681.1 | C141 | The role of His349 in receptor-stimulated iron release from the
C-lobe of transferrin |
ASN Poster Session: Diet, Food Security, and Health Promotion
Monday, April 20
(I) 12:45 pm – 1:45 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 737.7 (I) | B252 | Food insecurity is associated with iron deficiency anemia in
U.S. adolescents |
Tuesday, April 21
APS Poster Session: Hepcidin and Iron Homeostasis
Tuesday, April 21
12:45 pm – 3:00 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 974.1 | D326 | The hereditary hemochromatosis protein, HFE, is present in substoichiometric concentrations with respect to transferrin receptors 1 and 2 in the liver |
| 974.2 | D327 | Hepatocyte growth factor (HGF) suppresses hepcidin expression in hepatocytes by interfering with BMP-mediated hepcidin induction Julia Goodnough, Elizabeta Nemeth, Tomas Ganz David Geffen School of Medicine at UCLA, Los Angeles, CA |
| 974.3 | D328 | The pathogenesis of hereditary hemochromatosis Emilio Ramos, Tomas Ganz, Elizabeta Nemeth David Geffen School of Medicine at UCLA, Los Angeles, CA |
| 974.4 | D329 | The determinants of hepcidin-ferroportin interaction |
APS Poster Session: Metal-Ion Transport
Tuesday, April 21
12:45 pm – 3:00 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 975.1 | D330 |
Properties of the zinc transporter ZIP14 suggest a role in cellular uptake of nontransferrin- |
ASN Poster Session: Iron II
Tuesday, April 21
(I) 12:45 pm – 1:45 pm
(II) 1:45 pm – 2:45 pm
Ernest N Morial Convention Center, Exhibit Hall
Poster Board Numbers: B256–B269
| Program # | Board # | Title, Authors and Affiliations |
| 921.1 (I) | B256 | Dietary bioactive polyphenols inhibit heme iron absorption in human intestinal Caco-2 cells Qianyi Ma, Eun-Young Kim, Okhee Han Pennsylvania State University, University Park, PA |
| 921.2 (II) | B257 | Ascorbic acid offsets the inhibitory effect of bioactive dietary
polyphenolic compounds on basolateral iron transport in
Caco-2 human intestinal cells Eun-Young Kim, Soo-Kyung Ham, Okhee Han Pennsylvania State University, University Park, PA |
| 921.3 (I) | B258 | Contribution of tea to iron status in a rural female population Jane Marie Osowski1, Bonny Specker2 1The University of Southern Mississippi, Hattiesburg, MS; 2South Dakota State Universtiy, Brookings, SD |
| 921.4 (II) | B259 | Iron and zinc status are not affected by soy food
consumption in women of childbearing age Ying Zhou, D Lee Alekel, Ulrike Genschel, Manju B Reddy Iowa State University, Ames, IA |
| 921.5 (I) | B260 | Three types of dietary inulin exerted similar impacts on
expression profiles of iron-related genes in the intestine and
liver of young pigs K. Yasuda1, H D Dawson2, E Wasmuth1, K R Roneker1, K Kohn2, C Chen1,2, J F Urban2, R M Welch3, D D Miller1, X G Lei1 1Cornell University, Ithaca, NY; 2USDA, Beltsville, MD; 3USDA-ARS, Cornell University, Ithaca, NY |
| 921.6 (II) | B261 | Efficacy of iron supplementation for the maintenance of iron
status in female Soldiers during military training James P McClung1, J Philip Karl1, Sonya J Cable2, Kelly W Williams2, Andrew J Young1, Harris R Lieberman1 1US Army Research Institute of Environmental Medicine, Natick, MA; 2Directorate of Basic Combat Training, Experimentation and Analysis Element, Fort Jackson, SC |
| 921.7 (I) | B262 | Iron status and LDL-oxidation in a group of healthy adults
from Argentina. Preliminary results Silvia Langini1, Mabel Lardo1, Sergio Ghersevich2, María Aragone3, Claudio Carbia1, Marcela Pandolfo1, Silvana Fleischman1, Alberto Lazarowski1, María E Río1,4 1University of Buenos Aires, Buenos Aires, Argentina; 2National University of Rosario (UNR), Rosario, Argentina; 3Hospital Italiano, Buenos Aires, Argentina, 4CONICET, Buenos Aires, Argentina |
| 921.8 (II) | B263 | Effect of iron status on olfactory uptake of manganese and its
distribution in the brain Jonghan Kim1, Mark Böhlke2, Khristy Thompson1, Masaya Takahashi3, Siripan Phattanarudee2, Timothy Maher2, Marianne Wessling-Resnick1 1Harvard School of Public Health, Boston, MA; 2Massachusetts College of Pharmacy & Health Sciences, Boston, MA; 3Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA |
| 921.9 (I) | B264 | Signal transduction pathways are altered by cellular labile iron Narasimha Hegde, Lei Hao, Erica Unger, Okhee Han, John Beard Pennsylvania State University, University Park, PA |
| 921.10 (II) | B265 | Characterizing the chelatable/labile iron pool in mammalian
cells Natasha Hill1, Ben Rojas1, Vireak Thon1, Albert Beck1, Lena Tonnu1, Lina Planutyte1, Andrew Z Mason2, Maria C Linder1 1California State University, Fullerton, CA; 2California State University, Long Beach, CA |
| 921.11 (I) | B266 | Mechanisms of iron release from lysosomes |
| 921.12 (II) | B267 | Effect of cadmium on heme oxygenase-1 during cellular iron
deficiency Chengzhi Lai, George Loo University of North Carolina-Greensboro, Greensboro, NC |
| 921.13 (I) | B268 | Effects of iron and/or zinc deficiency on blood biochemical
parameters in rats Aki Konomi1,2, Katsuhiko Yokoi1 1Seitoku University, Matsudo, Japan; 2University of Shizuoka, Shizuoka, Japan |
| 921.14 (II) | B269 | Using the domestic chicken (Gallus gallus) as an in vivo
screening tool for Fe bioavailability |
ASN Poster Session: Zinc II
Tuesday, April 21
(I) 12:45 pm – 1:45 pm
(II) 1:45 pm – 2:45 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 922.1 (I) | B270 |
Zinc status in gastroenterological surgical patients. Association
with complications |
| 922.2 (II) | B271 | Zinc supplementation does not alter plasma trace elements in
Kenyan adults Angus Scrimgeour1, Henry C Lukaski2, Mark E Polhemus3, Lucas Otieno4, Andrew J Young1, Maria E Bovill5 1USARIEM, Natick, MA; 2Grand Forks Human Nutrition Research Center, Grand Forks, ND; 3USAMRU-K, Kisumu, Kenya; 4KEMRI/Walter Reed Project, Kisumu, Kenya; 5AMEDDC&S, Ft Sam Houston, TX |
| 922.3 (I) | B272 | Bacterial protein expression is altered by treatment with
zinc nanoparticles Arthur Grider1, Nadine J Kabengi2, Paul M Bertsch2, Andrew Neal3 1University of Georgia, Athens, GA; 2University of Kentucky, Lexington, KY; 3Rothamsted Research, Harpenden, Hertfordshire, United Kingdom |
| 922.4 (II) | B273 | A comparison of zinc metabolism and status among young and
older Korean women Jihye Kim1, Hee Young Paik2, Hyojee Joung2, Leslie R Woodhouse3, Janet C King4 1Daegu University, Gyeongsan, Republic of Korea; 2Seoul National University, Seoul, Republic of Korea; 3USDA Western Human Nutrition Research Center, Davis, CA; 4Children's Hospital Oakland Research Institute, Oakland, CA |
| 922.5 (I) | B274 | Attenuation of ZnT2 in tumorigenic breast cancer cells results
in apoptosis Farnaz Foolad, Veronica Lopez, Shannon L Kelleher Pennsylvania State University, University Park, PA |
| 922.6 (II) | B275 | Effects of DTPA on zinc flux in leukemia cell lines Kavitha Sankavaram, Bruce J Grattan, Hedley C Freake University of Connecticut, Storrs, CT |
| 922.7 (I) | B276 | Zinc (Zn) modulates the stress response in cadmium (Cd)
treated cultured choroid plexus Jennifer L Bradley, Robin K Young, Alice R Villalobos Texas A&M University, College Station, TX |
| 922.8 (II) | B277 | Nuclear and mitochondrial functions of p53 in zinc deficient
human neuronal precursor cells Rikki S Corniola, Cathy W Levenson Florida State University, Tallahassee, FL |
Other Scientific Presentations of Interest—Tuesday, April 21
ASBMB Poster Presentation: RNA Structure, Function, and Regulation
Tuesday, April 21
12:20 pm – 1:25 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 845.2 | C38 |
Selective decrease in regulatory iron response protein 1
(IRP1) binding to mRNA iron response element (IRE) |
ASN Poster Presentation: Early Life Nutrition and the Development of Adult Onset Disease
Tuesday, April 21
(I) 12:45 pm – 1:45 pm
Ernest N Morial Convention Center, Exhibit Hall
| Program # | Board # | Title, Authors and Affiliations |
| 913.1 (I) | B184 |
Maternal zinc deficiency affects postnatal growth and glucose
homeostasis in rat pups differently depending upon adequacy
of nutrient intake |
Meeting Abstracts
Abstracts of presentations at Experimental Biology 2009 were published in the FASEB Journal, volume 23. To search abstracts, click here.
APS GI & Liver Section Banquet
This year we ventured to The Court of Two Sisters for the APS GI & Liver Section Banquet and enjoyed the opportunity to meet informally with colleagues over a fabulous dinner (at a discounted price thanks to the generosity of Takeda Pharmaceutical). Visit the banquet website.
Travel Awards
Undergraduate and graduate students, postdoctoral fellows, clinical trainees, and early-career faculty were eligible for the following travel awards from the APS and ASN.
APS Gastrointestinal and Liver Physiology Section Travel Awards [details]
APS Cell and Molecular Physiology Section Travel Awards [details]
American Society for Nutrition Graduate Student Awards [details]
APS David S Bruce Awards for Excellence in Undergraduate Research [details]
APS International Awards [details]
APS Minority Travel Awards [details]
Upcoming Meetings
East Coast Iron Club — New York, NY, 26 October 2009
Experimental Biology 2010 — Anaheim, CA, 24–28 April 2010
Experimental Biology 2011 — Washington, DC, 9–13 April 2011
International BioIron Congress — Vancouver, BC, Canada, 22–26 May 2011
Trace Elements in Man and Animals (TEMA) — Enshi City, Hubei, China, 16–20 October 2011
Positions Available
Postdoctoral Position: Molecular Physiology of Membrane Transport
Laboratory of Bryan Mackenzie PhD
University of Cincinnati College of Medicine, Cincinnati, OH
Postdoctoral Position: Systemic Iron Regulation
Laboratory of Ella Nemeth PhD, Tomas Ganz MD PhD
David Geffen–UCLA School of Medicine, Los Angeles, CA
Technician: Systemic Iron Regulation
Laboratory of Ella Nemeth PhD, Tomas Ganz MD PhD
David Geffen–UCLA School of Medicine, Los Angeles, CA
Metals at EB2009 is offered in order to provide information about sessions at Experimental Biology relating to the transport and metabolism of iron and other transition metals, and to generate special interest in iron-related topics at Experimental Biology particularly in even years, alternating with the BioIron Congress. For information about Iron Transport at EB2006 click here. For information about Iron Transport at EB2008 click here.
This web site was last updated September 20, 2009. Contact: Bryan Mackenzie, University of Cincinnati.
