Printer Friendly Version
Iron Transport at EB2008
Experimental Biology in San Diego, April 5–9, 2008 featured the following sessions relating to iron transport and metabolism, sponsored by the American Physiological Society (APS) and the American Society for Nutrition (ASN).
ASN/APS Symposium: Hepcidin Regulation of Iron Transport
ASN Poster Session: Nutrient-Gene Interactions and Mineral Metabolism
ASN Poster Session: Iron I
ASN Minisymposium: Nutrient-Gene Interactions II
ASN Minisymposium: Iron II
APS Poster Session: Hepcidin and Iron Homeostasis
APS Poster Session: Metal-Ion Transport
Other Scientific Sessions of Interest
APS GI & Liver Section Banquet
Meeting Abstracts
Upcoming Meetings
Positions Available
Sunday, April 6, 2008
ASN/APS Symposium: Hepcidin Regulation of Iron Transport
Supported by educational grants from Xenon Pharmaceuticals and Intrinsic LifeSciences
| Chair: | Marianne Wessling-Resnick, Harvard School of Public Health, Boston, MA |
| Co-chairs: | Mitchell D Knutson, University of Florida, Gainesville, FL James F Collins, University at Buffalo-SUNY, Buffalo, NY |
| Time | Title, Presenter and Affiliation |
| 10:30 am | Regulation of hepcidin by iron Elizabeta Nemeth PhD David Geffen–UCLA School of Medicine, Los Angeles, CA |
| 10:54 am | Prohepcidin and iron absorption in healthy women Janet R Hunt PhD RD USDA–ARS Grand Forks Human Nutrition Research Center, Grand Forks, ND |
| 11:18 am | Molecular interaction of hepcidin with ferroportin: Binding and internalization Ivana DeDomenico PhD University of Utah School of Medicine, Salt Lake City, UT |
| 11:42 am | Characterization of the interaction of MPS cell expressed FPN with hepdicin David J Haile MD Audie Murphy–VA Hospital, University of Texas Health Science Center, San Antonio, TX |
| 12:08 pm | Hepcidin, iron status and infection Marianne Wessling-Resnick PhD Harvard School of Public Health, Boston, MA |
ASN Poster Session: Nutrient-Gene Interactions and Mineral Metabolism
| Program # | Board # | Title, Authors and Affiliations |
| 692.1 (I) | C149 | Two discrete zinc transporter-2 variants integrate zinc secretion and efflux in mammary epithelial cells Veronica Lopez, Shannon L Kelleher Pennsylvania State University, State College, PA |
| 692.2 (II) | C150 | Zinc transporter-2 is associated with mitochondria and functions as a zinc transporter in mammary epithelial cells Shannon L Kelleher, Veronica Lopez Pennsylvania State University, State College, PA |
| 692.3 (I) | C151 | Zinc regulation of bone-specific transcription factor Runx2 and bone marker gene expression within 24 hours in osteoblastic MC3T3-E1 cells Young-Eun Cho, Ria-Ann R Lomeda, Hyun-Ju Seo, Hong-In Shin, Je-Young Choi, John H Beattie, In-Sook Kwon Andong National University, Andong, Republic of Korea; Kyungpook National University, Daegu, Republic of Korea; Rowett Research Institute, Aberdeen, UK |
| 692.4 (II) | C152 | Iron supplementation modulates genes involved in oxidoreductase activity, including prostaglandin-endoperoxide synthase 2 in intestinal tumors James Swain, Chunbiao Li, Patrick Leahy Case Western Reserve University, Cleveland, OH |
| 692.5 (I) | C153 | Ferroportin modulates macrophage-mediated immune responses Erin E Johnson, Megan Murray, Marianne Wessling-Resnick Harvard School of Public Health, Boston, MA |
| 692.6 (II) | C154 | Effects of iron chelators on iron export across the basolateral membrane of human intestinal Caco-2 cells Eun-Young Kim, Okhee Han Pennsylvania State University, University Park, PA |
| 692.7 (I) | C155 | Effect of copper deficiency on intestinal gene expression in beef cattle Valencia D Rilington, Stephanie L Hansen, Julie A Hicks, Jerry W Spears, Hsiao-Ching Liu North Carolina State University, Raleigh, NC |
| 692.8 (II) | C156 | A few hypertensive humans respond to magnesium supplements with a rise in blood pressure, suggesting a genetic subgroup in response to nutritional Mg A Rosanoff Center for Magnesium Education and Research, Pahoa, HI |
| 692.9 (I) | C157 | DMT1 is not involved in uptake of copper from the blood plasma by hepatic and mammary epithelial cells Mizue Moriya, Yi-Hsuan Ho, Eric Sauble, Leigh Ackland, Julian F B Mercer, Maria C Linder California State University, Fullerton, CA; Deakin University, Burwood, Australia |
ASN Poster Session: Iron I
| Program # | Board # | Title, Authors and Affiliations |
| 694.1 (I) | C161 | Iron supplementation and changes in iron absorption and iron status during pregnancy and lactation Leslie R Woodhouse, Steven A Abrams, Zhensheng Chen, Ian J Griffin, Janet C King, Concepción Mendoza, Ratna Mukherjea, Fernando Viteri USDA, Davis, CA; Children's Nutrition Research Center, Houston, TX; Children's Hospital of Oakland Research Institute, Oakland, CA |
| 694.2 (II) | C162 | Moderate iron deficiency and physical training affect body fat accretion in growing male rats James P McClung, Nancy E Andersen, Tyson N Tarr, Chad H Stahl, Andrew J Young US Army Research Institute of Environmental Medicine, Natick, MA; North Carolina State University, Raleigh, NC |
| 694.3 (I) | C163 | Intestinal tumors adapt to excess dietary iron by altering expression of lipocalin-2 and divalent metal ion transporter James Swain, Chunbiao Li, Patrick Leahy Case Western Reserve University, Cleveland, OH |
| 694.4 (II) | C164 | Ventral midbrain vs. striatal iron infusion to correct altered in vivo dopaminergic signaling in ID rats Laura E Bianco, Sarah E Rundle, Lindsay H Ghramm, John L Beard Pennsylvania State University, University Park, PA |
| 694.5 (I) | C165 | Glycosaminoglycans isolated from fish muscle enhance iron uptake by Caco-2 cells José M Laparra Llopis, Elad Tako, Raymond P Glahn, Dennis D Miller Cornell University, Ithaca, NY; USDA, Ithaca, NY |
| 694.6 (II) | C166 | Effects of three types of inulin on dietary iron bioavailability and site of their disappearance in the digestive tract of young pigs Koji Yasuda, Karl R Roneker, Sarah Rice, Ross M Welch, Dennis D Miller, Xin Gen Lei Cornell University, Ithaca, NY; USDA, Ithaca, NY |
| 694.7 (I) | C167 | Dietary iron deficiency in strain 40 BXD mice causes diurnal-dependent alterations in brain iron and activity Erica L Unger, Denise M Konrad, Laura E Bianco, Byron C Jones, John L Beard Pennsylvania State University, University Park, PA |
| 694.8 (II) | C168 | Iron absorptive capacity in children with periodic limb movements of sleep Arlyce F Vanness, Sian Lei, Norman R Friedman, Keith L Cavanaugh, K Michael Hambidge, Carole E Kline, Nancy F Krebs University of Colorado, Denver, CO; University of Colorado, Aurora, CO |
| 694.9 (I) | C169 | Iron chelation in PC12 cells alters the mRNA expression of monoamine-related proteins Erica L Unger, Lei Hao, Eduardo G Gonzalez, John L Beard Pennsylvania State University, University Park, PA; Universidad Simón Bolívar, Caracas, Venezuela |
| 694.10 (II) | C170 | Genetic variations in ventral midbrain iron influence diurnal locomotor activity and body temperature in BXD mice Erica L Unger, Matthew E Sterling, Byron C Jones, John L Beard Pennsylvania State University, University Park, PA |
| 694.11 (I) | C171 | Markers of iron status in highly active and sedentary young women Megan M St Thomas, Kathleen Woolf, Nicole L Hahn, Linda A Vaughn, Pamela S Hinton, Amanda Carlson Arizona State University, Mesa, AZ; University of Missouri, Columbia, MO; Athletes' Performance, Tempe, AZ |
| 694.12 (II) | C172 | The quantitation of ferritin in the seeds of staple crops: ELISA method development Manju B Reddy, Rebecca Lukac, Alura Maneesha Iowa State University, Ames, IA |
| 694.13 (I) | C173 | Soy sauce fortified with NaFe-EDTA significantly improves iron status for the middle-aged and the aged Sishun Wang, Xian-Eng Zhao, Qiliang Lu Guizhou Provincial Center for Disease Prevention and Control, PR China |
ASN Minisymposium: Nutrient-Gene Interactions II
| Chair: | Mitchell D Knutson, University of Florida, Gainesville, FL |
|
| Program # | Time | Title, Authors and Affiliations |
| Lecture | 3:00 pm | Effect of low and high dose folic acid and the methylenetetrahydrofolate reductase (MTHFR) 677C–>T polymorphism on DNA methylation response Krista Crider National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA |
| 155.1 | 3:15 pm | The role of gender and gentic polymorphisms on choline biosynthesis Mary E Resseguie, I J Davis, S H Zeisel University of North Carolina, Chapel Hill, NC; University of North Carolina Nutrition Research Institute, Kannapolis, NC |
| 155.2 | 3:30 pm | Negative predictive adaptive response of a high protein weaning diet in rats exposed to a high fat/sugar diet in adulthood Alannah D Maurer, R A Reimer University of Calgary, Alberta, Canada |
| 155.3 | 3:45 pm | MicroRNA mediates post-transcriptional expression of human lactoferrin receptor (hLfR) Yalin Liao, Bo Lönnerdal University of California, Davis, CA |
| 155.4 | 4:00 pm | Dietary iron deficiency increases Zip14 expression in rats Hyeyoung Nam, S Gulec, Mitchell D Knutson University of Florida, Gainesville, FL |
| 155.5 | 4:15 pm | Influence of in vivo polyunsaturated fatty acid supplementation on expression of proximal signal transduction genes Kelly Lynn Weaver, P Ivester, F H Chilton Wake Forest School of Medicine, Winston-Salem, NC |
| 155.6 | 4:30 pm | Post-translational regulation of LXRb: The role of ligand stability in enhancing protein stability Stephen L Clarke, J J Repa Oklahoma State University, Stillwater, OK; University of Texas Southwestern Medical Center, Dallas, TX |
| 155.7 | 4:45 pm | Long-term caloric restriction causes dysregulation in cellular redox status in the skeletal muscle of the Cu/Zn-SOD mutant G93A mouse, an animal model of ALS Barkha Patel, S Raha, M A Tarnopolsky, M J Hamadeh York University, Toronto, Ontario, Canada; McMaster University, Hamilton, Ontario, Canada |
Monday, April 7, 2008
ASN Minisymposium: Iron II
| Chair: | James H Swain, Case Western Reserve University, Cleveland, OH | |
| Co-chair: | James P McClung, United States Army Research Institute of Environmental Medicine, Natick, MA |
|
| Program # | Time | Title, Authors and Affiliations |
| 304.1 | 10:30 am | HFE inhibits non transferrin-bound iron uptake via downregulating Zip14 in HepG2 cells Junwei Gao, Ningning Zhao, Mitchell D Knutson, Caroline A Enns Oregon Health & Science University, Portland, OR; University of Florida, Gainesville, FL |
| 304.2 | 10:45 am | Modulation of transferrin-bound iron uptake by Zip14 Ningning Zhao, Junwei Gao, Caroline A Enns, Mitchell D Knutson University of Florida, Gainesville, FL; Oregon Health & Science University, Portland, OR |
| 304.3 | 11:00 am | Decreased hephaestin expression and activity leads to decreased iron efflux from differentiated Caco2 cells Chris Vulpe, Zouhair K Attieh, Huijun Chen University of California, Berkeley, CA; American University of Science and Technology, Lebanon |
| 304.4 | 11:15 am | Effects of dietary bioactive polyphenoids on iron transport in human intestinal Caco-2 cells Eun-Young Kim, Soo-Kyung Ham, Mark K Shigenaga, Okhee Han Pennsylvania State University, University Park, PA; Children's Hospital Oakland Research Institute, Oakland, CA |
| 304.5 | 11:30 am | Fe and Zn bioavailability from red (merlot) and white (great northern) bean-based (Phaseolus vulgaris) diets fed to anemic young pigs Elad Tako, R P Glahn, R M Welch, X Lei, José M Laparra, M Rutzke, Dennis D Miller Cornell University, Ithaca, NY |
| 304.6 | 11:45 am | Postprandial effects of iron supplementation provided either with a meal or between meals on iron status and oxidative stress Z Yang, B Lönnerdal, K H Brown, L H Allen, K G Dewey University of California, Davis, CA; USDA, Davis, CA |
| 304.7 | 12:00 pm | Risk of severe depressive mood decreases with improving hemoglobin levels, but only when daytime salivary cortisol concentration is low Maike Rahn, Jere D Haas, Sonia L Hernández-Cordero, Fabricio A Campirano, Salvador Villapando, Juan Rivera Cornell University, Ithaca, NY; Instituto Nacional de Salud Pública, Cuernavaca, Mexico |
| 304.8 | 12:15 pm | Hierarchical recognition of iron responsive elements by iron regulatory protein 1 J B Goforth, R S Eisenstein University of Wisconsin, Madison, WI |
Tuesday, April 8, 2008
APS Poster Session: Hepcidin and Iron Homeostasis
| Program # | Board # | Title, Authors and Affiliations |
| 1191.1 | F251 | Iron-depletion limits intracellular bacterial growth in
macrophages Prasad Paradkar, Ivana De Domenico, Jerry Kaplan, Diane McVey Ward University of Utah, Salt Lake City, UT |
| 1191.2 | F252 | Temporal and dose-dependent effects of hepcidin in cultured
macrophages and intestinal epithelial cells Paul Sharp1, Bomee Chung1, Timothy Chaston1, Surjit Kaila Srai2 1King's College London, London, UK; 2University College London, London, UK |
| 1191.3 | F253 | Gated pore mutation affects ferritin iron in vivo Mohammad Rubayet Hasan1, Elizabeth C Theil1,2 1Children's Hospital Oakland Research Institute, Oakland, CA; 2University of California, Berkeley, CA |
| 1191.4 | F254 | Ferroportin residue C326 is critical for its interaction with
hepcidin Elizabeta Nemeth, Augustine Fernandes, Tomas Ganz David Geffen–UCLA School of Medicine, Los Angeles, CA |
| 1191.5 | F255 | Altered expression of iron-management proteins in the brain
microvasculature of Restless Legs Syndrome Padmavathi Ponnuru1, Xinsheng Wang1, Christopher Earley2, Richard P Allen3, James R Connor1 1Pennsylvania State University, Hershey, PA; 2Johns Hopkins University, Baltimore, MD |
| 1191.6 | F256 | Hepcidin-regulated and hepcidin–independent iron release pathways in hepatocytes and macrophages Erika V Valore, Tomas Ganz David Geffen–UCLA School of Medicine, Los Angeles, CA |
| 1191.7 | F257 | Ferroportin inhibits HIV-1 transcription Sergei Nekhai1, Altreisha Foster1, Min Xu1, Xiaomei Niu1, Mitchell D Knutson2, Victor R Gordeuk1 1Howard University, Washington, DC; 2University of Florida, Gainesville, FL |
| 1191.8 | F258 | The role of hepcidin in anemia of inflammation and anemia of
cancer Seth Rivera, Martha Pastuszka, Alice Yu, Tomas Ganz David Geffen–UCLA School of Medicine, Los Angeles, CA |
| 1191.9 | F259 | A direct effect of erythropoietin on hepcidin expression
involving EPOR signaling Jorge P Pinto1, Sara Ribeiro1, Helena Pontes2, Shifaan Thowfeequ3, David Tosh3, Félix Carvalho2, Graça Porto1,4 1IBMC, Porto, Portugal; 2University of Porto, Porto, Portugal; 3University of Bath, Bath, UK; 4Santo Antonio General Hospital, Porto, Portugal |
| 1191.10 | F260 | Inhibition of HIV-1 transcription by DpT-based iron chelators Zufan Kebede Debebe1, Xiaomei Niu1, Dillon Robinson1, Des Richardson2, Marina Jerebtsova3, Patricio Ray3, Victor Gordeuk1, Sergei Nekhai1 1Howard University, Washington, DC; 2University of Sydney, Sydney, Australia; 3Children’s National Medical Center, Washington, DC |
| 1191.11 | F261 | The effect of IL-6 in the anemia of inflammation Martha Katherine Pastuszka, Alice Yu, Tomas Ganz, Seth Rivera David Geffen–UCLA School of Medicine, Los Angeles, CA |
| 1191.12 | F262 | Ectopic hepcidin production in anemia of cancer Alice Yu, Martha Katherine Pastuszka, Tomas Ganz, Seth Rivera David Geffen–UCLA School of Medicine, Los Angeles, CA |
APS Poster Session: Metal-Ion Transport
| Program # | Board # | Title, Authors and Affiliations |
| 1192.1 | F263 | Lactational hormones increase expression of milk proteins but
do not enhance uptake of copper by mammary epithelial cells Stephen Kim1, Christine Kassissa1, Theodros Z Kidane1, Leigh Ackland2, Julian F B Mercer2, Maria C Linder1 1California State University, Fullerton, CA; 2Deakin University, Burwood, Australia |
| 1192.2 | F264 | A role for the divalent metal-ion transporter (DMT1) is doubtful in the mechanism by which calcium-channel blockers reverse iron overload Bryan Mackenzie1, Ali Shawki1, Andrew J Ghio2, Jacqueline D Stonehuerner2, Lin Zhao3, Saied Ghadersohi3, Laura M Garrick3, Michael D Garrick3 1University of Cincinnati, Cincinnati, OH; 2US Environmental Protection Agency, Chapel Hill, NC; 3State University of New York–Buffalo, Buffalo, NY |
| 1192.3 | F265 | Molecular impact of divalent metal-ion transporter (DMT1) mutations (V114del and G212V) found in a compound heterozygote with microcytic anemia and hepatic iron overload Ali Shawki, Anthony C Illing, Bryan Mackenzie University of Cincinnati, Cincinnati, OH |
| 1192.4 | F266 | Induction of arachidonate 12-lipoxygenase (Alox15) alters
intestinal lipid homeostasis during iron-deficiency James F Collins University at Buffalo, State University of New York, Buffalo, NY |
Other Scientific Sessions of Interest
ASN Posters: 695. Copper I
ASN Posters: 696. Zinc
ASN Symposium: Infant and Young Child Iron Deficiency and Iron Deficiency Anemia in Developing
Countries:
The Critical Role of Research to Guide Policy and Programs
ASN Posters: 895. Micronutrients: Iron
APS Posters: 936. Transporters: Ions, Transmitters, Nutrients, Metabolites and Drugs
ASBMB Posters: 813. Structure and Function of Transport Proteins and Channels
| Program # | Board # | Title, Authors and Affiliations |
| 813.16 | A361 | Structural studies of Steap3, the human erythroid ferric reductase, suggest a gating mechanism for electron transfer across the endosomal membrane C Martin Lawrence, Anoop K Sendamarai, Robert S Ohgami, Mark D Fleming Montana State University, Bozeman, MT; Children's Hospital Boston and Harvard Medical School, Boston, MA |
ASN Minisymposium: 443. Copper II
Chair: Joseph R Prohaska, University of Minnesota, Duluth, MN
Co-chair: Maria C Linder, California State University, Fullerton, CA
APS Posters: 1193. Nutrient and Electrolyte Absorption
Meeting Abstracts
Abstracts of presentations at Experimental Biology 2008 were published in the FASEB Journal, volume 22. To search abstracts, click here.
APS GI & Liver Section Banquet
Thanks for joining us for an enjoyable evening of fine dining and great company, and the opportunity to meet with other investigators in the field of iron transport and metabolism. This year we went 'chic Greek' at one of San Diego's newest restaurants, EXY (pronounced as in sexy) at the APS GI & Liver Section Banquet, Monday, April 7, 2008.
Upcoming Meetings
Trace Elements in Man and Animals (TEMA) — Pucón, Chile, 9–13 November 2008
Metals at Experimental Biology 2009 — New Orleans, LA, 18–22 April 2009
BioIron Congress — Porto, Portugal, 7–11 June 2009
Experimental Biology 2010 — Anaheim, CA, 24–28 April 2010
Positions Available
Postdoctoral Position: Molecular Physiology of Membrane Transport
Laboratory of Bryan Mackenzie PhD
University of Cincinnati College of Medicine, Cincinnati, OH
Postdoctoral Position: Systemic Iron Regulation
Laboratory of Ella Nemeth PhD, Tomas Ganz MD PhD
David Geffen–UCLA School of Medicine, Los Angeles, CA
Technician: Systemic Iron Regulation
Laboratory of Ella Nemeth PhD, Tomas Ganz MD PhD
David Geffen–UCLA School of Medicine, Los Angeles, CA
Iron Transport at EB2008 is offered in order to provide information about sessions at Experimental Biology relating to iron transport and metabolism and to generate special interest in iron-related topics at Experimental Biology particularly in even years, alternating with the BioIron Congress. For information about Iron Transport at EB2006 click here.
This web site was last updated October 10, 2008. Contact: Bryan Mackenzie, University of Cincinnati.
