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Department of Internal Medicine

Hematology & Oncology

Photo of  Pier Paolo Scaglioni, MD

Pier Paolo Scaglioni, MD

Education/Credentials
  • MD: University of Modena Medical School
  • Residency: University of Modena Medical School
  • Research Fellowship: Massachusetts General Hospital
  • Residency: Montefiore Medical Center
  • Fellowship: Memorial Sloan Kettering Cancer Center
  • Research Fellowship: Memorial Sloan Kettering Cancer Center

Board Certifications & Licenses
  • American Board of Internal Medicine 08/21/2001
  • American Board of Internal Medicine (Medical Oncology) 11/03/2004
Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Ave
  • Cincinnati, Ohio 45267

Peer Reviewed Publications

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Gupta, Arjun; Saltarski, Jessica M; White, Michael A; Scaglioni, Pier P; Gerber, David E 2017. Therapeutic Targeting of Nuclear Export Inhibition in Lung Cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 12 9, 1446-1450

Rabellino, Andrea; Andreani, Cristina; Scaglioni, Pier Paolo 2017. The Role of PIAS SUMO E3-Ligases in Cancer. Cancer research, 77 7, 1542-1547

Constanzo, Jerfiz D; Deng, Mi; Rindhe, Smita; Tang, Ke-Jing; Zhang, Cheng-Cheng; Scaglioni, Pier Paolo 2016. Pias1 is essential for erythroid and vascular development in the mouse embryo. Developmental biology, 415 1, 98-110

Constanzo, Jerfiz D; Tang, Ke-Jing; Rindhe, Smita; Melegari, Margherita; Liu, Hui; Tang, Ximing; Rodriguez-Canales, Jaime; Wistuba, Ignacio; Scaglioni, Pier Paolo 2016. PIAS1-FAK Interaction Promotes the Survival and Progression of Non-Small Cell Lung Cancer. Neoplasia (New York, N.Y.), 18 5, 282-93

Kim, Jimi; McMillan, Elizabeth; Kim, Hyun Seok; Venkateswaran, Niranjan; Makkar, Gurbani; Rodriguez-Canales, Jaime; Villalobos, Pamela; Neggers, Jasper Edgar; Mendiratta, Saurabh; Wei, Shuguang; Landesman, Yosef; Senapedis, William; Baloglu, Erkan; Chow, Chi-Wan B; Frink, Robin E; Gao, Boning; Roth, Michael; Minna, John D; Daelemans, Dirk; Wistuba, Ignacio I; Posner, Bruce A; Scaglioni, Pier Paolo; White, Michael A 2016. XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature, 538 7623, 114-117

Padanad, Mahesh S; Konstantinidou, Georgia; Venkateswaran, Niranjan; Melegari, Margherita; Rindhe, Smita; Mitsche, Matthew; Yang, Chendong; Batten, Kimberly; Huffman, Kenneth E; Liu, Jingwen; Tang, Ximing; Rodriguez-Canales, Jaime; Kalhor, Neda; Shay, Jerry W; Minna, John D; McDonald, Jeffrey; Wistuba, Ignacio I; DeBerardinis, Ralph J; Scaglioni, Pier Paolo 2016. Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell reports, 16 6, 1614-1628

Rabellino, Andrea; Melegari, Margherita; Tompkins, Van S; Chen, Weina; Van Ness, Brian G; Teruya-Feldstein, Julie; Conacci-Sorrell, Maralice; Janz, Siegfried; Scaglioni, Pier Paolo 2016. PIAS1 Promotes Lymphomagenesis through MYC Upregulation. Cell reports, 15 10, 2266-2278

Scaglioni, Priscila Tessmer; Badiale-Furlong, Eliana 2016. Rice husk as an adsorbent: A new analytical approach to determine aflatoxins in milk. Talanta, 152 , 423-31

Tang, Ke-Jing; Constanzo, Jerfiz D; Venkateswaran, Niranjan; Melegari, Margherita; Ilcheva, Mariya; Morales, Julio C; Skoulidis, Ferdinandos; Heymach, John V; Boothman, David A; Scaglioni, Pier Paolo 2016. Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 22 23, 5851-5863

Chakrabarti, Gaurab; Moore, Zachary R; Luo, Xiuquan; Ilcheva, Mariya; Ali, Aktar; Padanad, Mahesh; Zhou, Yunyun; Xie, Yang; Burma, Sandeep; Scaglioni, Pier P; Cantley, Lewis C; DeBerardinis, Ralph J; Kimmelman, Alec C; Lyssiotis, Costas A; Boothman, David A 2015. Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone. Cancer & metabolism, 3 , 12

Rajagopalan, Kartik N; Egnatchik, Robert A; Calvaruso, Maria A; Wasti, Ajla T; Padanad, Mahesh S; Boroughs, Lindsey K; Ko, Bookyung; Hensley, Christopher T; Acar, Melih; Hu, Zeping; Jiang, Lei; Pascual, Juan M; Scaglioni, Pier Paolo; DeBerardinis, Ralph J 2015. Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells. Cancer & metabolism, 3 , 7

Ramadori, Giorgio; Konstantinidou, Georgia; Venkateswaran, Niranjan; Biscotti, Tommasina; Morlock, Lorraine; Galié, Mirco; Williams, Noelle S; Luchetti, Michele; Santinelli, Alfredo; Scaglioni, Pier Paolo; Coppari, Roberto 2015. Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis. Cell metabolism, 21 1, 117-25

Scaglioni, P T; Becker-Algeri, T; Drunkler, D; Badiale-Furlong, E 2014. Aflatoxin B? and M? in milk. Analytica chimica acta, 829 , 68-74

Schuster, Katja; Venkateswaran, Niranjan; Rabellino, Andrea; Girard, Luc; Peña-Llopis, Samuel; Scaglioni, Pier Paolo 2014. Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesis. Molecular cancer research : MCR, 12 6, 912-23

Konstantinidou, Georgia; Ramadori, Giorgio; Torti, Francesca; Kangasniemi, Kim; Ramirez, Rachel E; Cai, Yiran; Behrens, Carmen; Dellinger, Michael T; Brekken, Rolf A; Wistuba, Ignacio I; Heguy, Adriana; Teruya-Feldstein, Julie; Scaglioni, Pier Paolo 2013. RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas. Cancer discovery, 3 4, 444-57

Rabellino, Andrea; Scaglioni, Pier Paolo 2013. PML Degradation: Multiple Ways to Eliminate PML. Frontiers in oncology, 3 , 60

Rabellino, Andrea; Carter, Brandon; Konstantinidou, Georgia; Wu, Shwu-Yuan; Rimessi, Alessandro; Byers, Lauren A; Heymach, John V; Girard, Luc; Chiang, Cheng-Ming; Teruya-Feldstein, Julie; Scaglioni, Pier Paolo 2012. The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. Cancer research, 72 9, 2275-84

Scaglioni, Pier Paolo; Rabellino, Andrea; Yung, Thomas M; Bernardi, Rosa; Choi, Sooyeon; Konstantinidou, Georgia; Nardella, Caterina; Cheng, Ke; Pandolfi, Pier Paolo 2012. Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence. EMBO molecular medicine, 4 7, 594-602

Naina, Harris V; Levitt, Daniel; Vusirikala, Madhuri; Anderson, Larry D; Scaglioni, Pier Paolo; Kirk, Angela; Collins, Robert H 2011. Successful treatment of relapsed and refractory extramedullary acute promyelocytic leukemia with tamibarotene. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29 18, e534-6

Scaglioni, Pier Paolo; Cai, Lu Fan; Majid, Samia M; Yung, Thomas M; Socci, Nicholas D; Kogan, Scott C; Kopelovich, Levy; Pandolfi, Pier Paolo 2011. Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model. Genes & cancer, 2 2, 160-5

Schuster, K; Zheng, J; Arbini, A A; Zhang, C C; Scaglioni, P P 2011. Selective targeting of the mTORC1/2 protein kinase complexes leads to antileukemic effects in vitro and in vivo. Blood cancer journal, 1 9, e34

Sullivan, James P; Spinola, Monica; Dodge, Michael; Raso, Maria G; Behrens, Carmen; Gao, Boning; Schuster, Katja; Shao, Chunli; Larsen, Jill E; Sullivan, Laura A; Honorio, Sofia; Xie, Yang; Scaglioni, Pier P; DiMaio, J Michael; Gazdar, Adi F; Shay, Jerry W; Wistuba, Ignacio I; Minna, John D 2010. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer research, 70 23, 9937-48

Konstantinidou, Georgia; Bey, Erik A; Rabellino, Andrea; Schuster, Katja; Maira, Michael S; Gazdar, Adi F; Amici, Augusto; Boothman, David A; Scaglioni, Pier Paolo 2009. Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. Cancer research, 69 19, 7644-52

Scaglioni, P P; Yung, T M; Choi, S; Choi, S C; Baldini, C; Konstantinidou, G; Pandolfi, P P 2008. CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor. Molecular and cellular biochemistry, 316 1-2, 149-54

Scaglioni, P P; Pandolfi, P P 2007. The theory of APL revisited. Current topics in microbiology and immunology, 313 , 85-100

Matsushita, Hiromichi; Scaglioni, Pier Paolo; Bhaumik, Mantu; Rego, Eduardo M; Cai, Lu Fan; Majid, Samia M; Miyachi, Hayato; Kakizuka, Akira; Miller, Wilson H; Pandolfi, Pier Paolo 2006. In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia. The Journal of experimental medicine, 203 4, 821-8

Scaglioni, Pier Paolo; Yung, Thomas M; Cai, Lu Fan; Erdjument-Bromage, Hediye; Kaufman, Andrew J; Singh, Bhuvanesh; Teruya-Feldstein, Julie; Tempst, Paul; Pandolfi, Pier Paolo 2006. A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell, 126 2, 269-83

Shen, Tian Huai; Lin, Hui-Kuan; Scaglioni, Pier Paolo; Yung, Thomas M; Pandolfi, Pier Paolo 2006. The mechanisms of PML-nuclear body formation. Molecular cell, 24 3, 331-9

Trotman, Lloyd C; Alimonti, Andrea; Scaglioni, Pier Paolo; Koutcher, Jason A; Cordon-Cardo, Carlos; Pandolfi, Pier Paolo 2006. Identification of a tumour suppressor network opposing nuclear Akt function. Nature, 441 7092, 523-7

Bernardi, Rosa; Scaglioni, Pier Paolo; Bergmann, Stephan; Horn, Henning F; Vousden, Karen H; Pandolfi, Pier Paolo 2004. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nature cell biology, 6 7, 665-72

Gurrieri, Carmela; Capodieci, Paola; Bernardi, Rosa; Scaglioni, Pier Paolo; Nafa, Khedoudja; Rush, Laura J; Verbel, David A; Cordon-Cardo, Carlos; Pandolfi, Pier Paolo 2004. Loss of the tumor suppressor PML in human cancers of multiple histologic origins. Journal of the National Cancer Institute, 96 4, 269-79

Scaglioni, Pier Paolo; Pandolfi, Pier Paolo 2003. Medicine: taking apart a cancer protein. Nature, 426 6966, 512-3

Mohr, L; Yoon, S K; Eastman, S J; Chu, Q; Scheule, R K; Scaglioni, P P; Geissler, M; Heintges, T; Blum, H E; Wands, J R 2001. Cationic liposome-mediated gene delivery to the liver and to hepatocellular carcinomas in mice. Human gene therapy, 12 7, 799-809

Melegari, M; Scaglioni, P P; Wands, J R 1998. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. Journal of virology, 72 3, 1737-43

Melegari, M; Scaglioni, P P; Wands, J R 1998. Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. Hepatology (Baltimore, Md.), 27 2, 628-33

Melegari, M; Scaglioni, P P; Wands, J R 1997. The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted. Journal of virology, 71 7, 5449-54

Scaglioni, P P; Melegari, M; Wands, J R 1997. Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame. Virology, 233 2, 374-81

Scaglioni, P P; Melegari, M; Wands, J R 1997. Posttranscriptional regulation of hepatitis B virus replication by the precore protein. Journal of virology, 71 1, 345-53

Wands, J R; Geissler, M; Putlitz, J Z; Blum, H; von Weizsäcker, F; Mohr, L; Yoon, S K; Melegari, M; Scaglioni, P P 1997. Nucleic acid-based antiviral and gene therapy of chronic hepatitis B infection. Journal of gastroenterology and hepatology, 12 9-10, S354-69

Scaglioni, P P; Melegari, M; Wands, J R 1996. Recent advances in the molecular biology of hepatitis B virus. Bailliere's clinical gastroenterology, 10 2, 207-25

Scaglioni, P; Melegari, M; Takahashi, M; Chowdhury, J R; Wands, J 1996. Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents. Hepatology (Baltimore, Md.), 24 5, 1010-7

Scaglioni, P P; Melegari, M; Wands, J R 1994. Characterization of hepatitis B virus core mutants that inhibit viral replication. Virology, 205 1, 112-20

Melegari, M; Scaglioni, P P; Pasquinelli, C; Manenti, F; Villa, E 1992. Hepatitis B virus specific transcripts in peripheral blood mononuclear cells. Archives of virology. Supplementum, 4 , 46-9

Villa, E; Melegari, M; Ferretti, I; Vecchi, C; Scaglioni, P P; De Palma, M; Manenti, F 1992. Presence of HCV RNA in serum of asymptomatic blood donors involved in post-transfusion hepatitis (PTH). Archives of virology. Supplementum, 4 , 247-8

Melegari, M; Jung, M C; Schneider, R; Santantonio, T; Bagnulo, S; Luchena, N; Pastore, G; Pape, G; Scaglioni, P P; Villa, E 1991. Conserved core protein sequences in hepatitis B virus infected patients without anti-HBc. Journal of hepatology, 13 2, 187-91

Villa, E; Ferretti, I; De Palma, M; Melegari, M; Scaglioni, P P; Trande, P; Vecchi, C; Fratti, N; Manenti, F 1991. HCV RNA in serum of asymptomatic blood donors involved in post-transfusion hepatitis (PTH). Journal of hepatology, 13 2, 256-9

Pasquinelli, C; Melegari, M; Villa, E; Scaglioni, P P; Seidenari, M; Mongiardo, N; De Rienzo, B; Manenti, F 1990. Hepatitis B virus infection of peripheral blood mononuclear cells is common in acute and chronic hepatitis. Journal of medical virology, 31 2, 135-40

Pasquinelli, C; Melegari, M; Villa, E; Seidenari, M; Scaglioni, P P; Tiribelli, C; Crocé, L S; Manenti, F 1990. Detection of hepatitis B virus transcripts in patients with chronic liver disease. Journal of hepatology, 10 2, 180-5

Melegari, M; Scaglioni, P P; Mao, G P; Pasquinelli, C; Baldini, G . [Estrogen receptors in the human liver]. Medicina (Florence, Italy), 10 2, 154-7

Scaglioni, P P; Melegari, M; Mao, G; Pasquinelli, C . [HBV DNA in mononuclear cells of peripheral blood in acute hepatitis B: a comparative analysis of Southern blot and polymerase chain reaction (PCR)]. Medicina (Florence, Italy), 10 1, 32-4

Villa, E; Melegari, M; Scaglioni, P P; Trande, P; Cesaro, P; Manenti, F . Hepatocellular carcinoma: risk factors other than HBV. The Italian journal of gastroenterology, 23 7, 457-60