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Department of Internal Medicine

Hematology & Oncology

Photo of  Vladimir Bogdanov, PhD

Vladimir Bogdanov, PhD

Associate Professor , Director, Hemostasis Research Program

Education/Credentials
  • Bachelor's Degree: I.P. Pavlov State Medical University of St. Petersburg
  • Master's Degree: Mount Sinai School of Medicine
  • Doctoral Degree: Mount Sinai School of Medicine
  • Fellowship : Mount Sinai School of Medicine

Research/Clinical Interests

Blood coagulation system plays many important roles in health and disease. Aside from clotting blood, coagulation proteases also contribute to such processes as angiogenesis and cellular proliferation / migration. I direct Hemostasis Research Program in the Division of Hematology/Oncology. At the present time, the Program is focused on two areas: I. Alternatively spliced Tissue Factor (asTF) as a therapeutic target in pancreatic cancer. asTF is a soluble form of Tissue Factor (TF), the trigger of blood clotting. We recently reported that asTF is elevated in pancreatic cancer and acts as a cell agonist promoting growth and spread of pancreatic cancer cells. Our newly developed inhibitory antibody against asTF is currently being tested in animal models. II. Red blood cells (RBC) as novel contributors to vascular dysfunction in acute and chronic inflammatory states. We discovered that RBC can contribute to heightened clotting and obesity-related atherosclerosis, in large part because the levels of pro-inflammatory chemokines bound to RBC become high due to high-fat diet. We hope that these observations will improve our understanding of RBC biology, and help develop new diagnostic and/or therapeutic strategies aimed at ameliorating obesity-related vascular disease. Key collaborators: Nigel Mackman, Ph.D., UNC Chapel Hill; Henri Versteeg, PhD, Leiden University; Xiaoyang Qi, Ph.D., University of Cincinnati; Neal Weintraub, M.D., Georgia Regents University; Theodosia Kalfa, M.D., Ph.D., Cincinnati Children’s Hospital and Medical Center.

Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue
  • ML 0508
  • Cincinnati, Ohio 45267-0508
  • Office 513-558-6276
  • Fax 513-558-6703
  • Email vladimir.bogdanov@uc.edu

Peer Reviewed Publications

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Lewis, Clayton S; Bogdanov, Vladimir Y 2019. KLF11 (Krüppel-Like Factor 11) Modulates Arterial Thrombosis. Arteriosclerosis, thrombosis, and vascular biology, 39 3, 309-310

Benson, Tyler W; Weintraub, Daniel S; Crowe, Matthew; Yiew, Nicole K H; Popoola, Orishebawo; Pillai, Ajay; Joseph, Joel; Archer, Krystal; Greenway, Charlotte; Chatterjee, Tapan K; Mintz, James; Stepp, David W; Stansfield, Brian K; Chen, Weiqin; Brittain, Julia; Bogdanov, Vladimir Y; Gao, Yan; Wilson, James G; Tang, Yaoliang; Kim, Ha Won; Weintraub, Neal L 2018. Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding. Molecular and cellular endocrinology, ,

Benson, Tyler W; Weintraub, Neal L; Kim, Ha Won; Seigler, Nichole; Kumar, Sanjiv; Pye, Jonathan; Horimatsu, Tetsuo; Pellenberg, Rod; Stepp, David W; Lucas, Rudolf; Bogdanov, Vladimir Y; Litwin, Sheldon E; Brittain, Julia E; Harris, Ryan A 2018. A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome. Laboratory investigation; a journal of technical methods and pathology, ,

Caversaccio, Nathalie I; Reina Caro, Maria D; Prince, Raja; Müller, Martin; Lewis, Clayton S; Bogdanov, Vladimir Y; Dufour, Jean-François; Angelillo-Scherrer, Anne 2018. Alternatively spliced tissue factor levels are elevated in the plasma of patients with chronic liver diseases. European journal of gastroenterology & hepatology, 30 12, 1470-1475

Ramchandani, Divya; Unruh, Dusten; Lewis, Clayton S; Bogdanov, Vladimir Y; Weber, Georg F 2016. Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditions. Laboratory investigation; a journal of technical methods and pathology, ,

Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y 2016. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget, 7 18, 25264-75

Bogdanov, Vladimir Y; Versteeg, Henri H 2015. "Soluble Tissue Factor" in the 21st Century: Definitions, Biochemistry, and Pathophysiological Role in Thrombus Formation. Seminars in thrombosis and hemostasis, 41 7, 700-7

Unruh, Dusten; Sagin, Farah; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Hart, Kimberly; Lindsell, Christopher J; Ahmad, Syed A; Bogdanov, Vladimir Y 2015. Levels of Alternatively Spliced Tissue Factor in the Plasma of Patients with Pancreatic Cancer May Help Predict Aggressive Tumor Phenotype. Annals of surgical oncology, 22 Suppl 3 , S1206-11

Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y 2015. Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis. Circulation, 132 20, 1898-908

Manka, David; Chatterjee, Tapan K; Stoll, Lynn L; Basford, Joshua E; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Tang, Yaoliang; Blomkalns, Andra L; Hui, David Y; Weintraub, Neal L 2014. Transplanted perivascular adipose tissue accelerates injury-induced neointimal hyperplasia: role of monocyte chemoattractant protein-1. Arteriosclerosis, thrombosis, and vascular biology, 34 8, 1723-30

Sluka, Susanna H M; Akhmedov, Alexander; Vogel, Johannes; Unruh, Dusten; Bogdanov, Vladimir Y; Camici, Giovanni G; Lüscher, Thomas F; Ruf, Wolfram; Tanner, Felix C 2014. Alternatively spliced tissue factor is not sufficient for embryonic development. PloS one, 9 5, e97793

Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y 2014. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. International journal of cancer, 134 1, 9-20

Chatterjee, Tapan K; Aronow, Bruce J; Tong, Wilson S; Manka, David; Tang, Yaoliang; Bogdanov, Vladimir Y; Unruh, Dusten; Blomkalns, Andra L; Piegore, Mark G; Weintraub, Daniel S; Rudich, Steven M; Kuhel, David G; Hui, David Y; Weintraub, Neal L 2013. Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis. Physiological genomics, 45 16, 697-709

Basavaraj, Manjunath Goolyam; Sovershaev, Mikhail A; Egorina, Elena M; Gruber, Franz X; Bogdanov, Vladimir Y; Fallon, John T; Østerud, Bjarne; Mathiesen, Ellisiv B; Hansen, John-Bjarne 2012. Circulating monocytes mirror the imbalance in TF and TFPI expression in carotid atherosclerotic plaques with lipid-rich and calcified morphology. Thrombosis research, 129 4, e134-41

Ekser, Burcin; Lin, Chih C; Long, Cassandra; Echeverri, Gabriel J; Hara, Hidetaka; Ezzelarab, Mohamed; Bogdanov, Vladimir Y; Stolz, Donna B; Enjyoji, Keiichi; Robson, Simon C; Ayares, David; Dorling, Anthony; Cooper, David K C; Gridelli, Bruno 2012. Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation. Transplant international : official journal of the European Society for Organ Transplantation, ,

Godby, Richard C; Van Den Berg, Yascha W; Srinivasan, Ramprasad; Sturm, Robert; Hui, David Y; Konieczny, Stephen F; Aronow, Bruce J; Ozhegov, Evgeny; Ruf, Wolfram; Versteeg, Henri H; Bogdanov, Vladimir Y 2012. Non-Proteolytic Properties of Murine Alternatively Spliced Tissue Factor: Implications for Integrin-Mediated Signaling in Murine Models. Molecular medicine (Cambridge, Mass.), ,

Lingrel, Jerry B; Pilcher-Roberts, Robyn; Basford, Joshua E; Manoharan, Palanikumar; Neumann, Jon; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Hui, David Y 2012. Myeloid-specific kruppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. Circulation research, 110 10, 1294-302

Srinivasan, R., Turner, K., Unruh, D., Qi, X., Chu, Z, Aronow, B.J., Kalthoff, H., Ozhegov, E., Kirchhofer, D., Ruf, W., Versteeg, H.H., Ahmad, S., Lucas, F.V., Bogdanov, V.Y. 2012. Alternatively Spliced Tissue Factor Contributes to Tumor Spread and Activation of Coagulation in Pancreatic Ductal Adenocarcinoma International Journal of Cancer, ,

Srinivasan, Ramprasad; Bogdanov, Vladimir Y 2012. Splice variants of Tissue Factor and integrin-mediated signaling. Thrombosis research, 129 Suppl 2 , S34-7

Wang, Jian-Guo; Geddings, Julia E; Aleman, Maria M; Cardenas, Jessica C; Chantrathammachart, Pichika; Williams, Julie C; Kirchhofer, Daniel; Bogdanov, Vladimir Y; Bach, Ronald R; Rak, Janusz; Church, Frank C; Wolberg, Alisa S; Pawlinski, Rafal; Key, Nigel S; Yeh, Jen Jen; Mackman, Nigel 2012. Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer. Blood, 119 23, 5543-52

Egorina, Elena M; Sovershaev, Mikhail A; Bogdanov, Vladimir Y; Sovershaev, Timofey A; Fallon, John T; Seredkina, Natalia; Østerud, Bjarne; Hansen, John-Bjarne 2011. Low thrombogenicity of calcified atherosclerotic plaques is associated with bone morphogenetic protein-2-dependent inhibition of tissue factor expression. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 22 8, 642-50

Srinivasan, R., Ozhegov, E., van den Berg, Y.W., Aronow, B.J., Franco, R.S., Palascak, M.B., Fallon, J.T., Ruf, W., Versteeg, H.H., Bogdanov, V.Y. 2011. Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling Journal of Thrombosis and Haemostasis, 9(10): , 2087-96

Srinivasan, Ramprasad; Bogdanov, Vladimir Y 2011. Alternatively spliced Tissue Factor: discovery, insights, clinical implications. Frontiers in bioscience : a journal and virtual library, 17 , 3061-71

Bogdanov, Vladimir Y; Osterud, Bjarne 2010. Cardiovascular complications of diabetes mellitus: The Tissue Factor perspective. Thrombosis research, 125 2, 112-8

Chandradas, Sajiv; Deikus, Gintaras; Tardos, Jonathan G; Bogdanov, Vladimir Y 2010. Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. Journal of leukocyte biology, 87 1, 147-52

Sovershaev, M.A., Egorina, E.M., Bogdanov, V.Y., Seredkina, N., Fallon, J.T., Valkov, A.Y. Osterud, B., & Hansen, J.B. 2010. Bone morphogenetic protein-7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor Thrombosis Research,, 126 4:, 306-10

Bogdanov, V.Y., Cimmio, G., Tardos, J.G., Tunstead, J.R., and Badimon, J.J. 2009. Assessment of Plasma Tissue Factor Activity in Patients Presenting with Coronary Artery Disease: Limitations of a Commercial Assay Journal of Thrombosis and Haemostasis, Vol.7, No. 5, pp. 894-897

Eisenreich, Andreas; Bogdanov, Vladimir Y; Zakrzewicz, Andreas; Pries, Axel; Antoniak, Silvio; Poller, Wolfgang; Schultheiss, Heinz-Peter; Rauch, Ursula 2009. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Circulation research, 104 5, 589-99

van den Berg, Y.W., van den Hengel, L.G., Myers, H.R., Ayachi, O., Jordanova, E., Ruf, W., Spek, C.A., Reitsma, P.H., Bogdanov, V.Y., and Versteeg, H.H. 2009. Alternatively Spliced Tissue Factor Induces Angiogenesis through Integrin Ligation Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 26, pp. 19496-19502

Tardos, J.G., Eisenreich, A., Deikus, G., Bechhofer, D.H., Chandradas, S., Zafar, U., Raugh U., and Bogdanov, V.Y. 2008. SR Proteins ASF/SF2 and SRp55 Participate in Tissue Factor Biosynthesis in Human Monocytic Cells Journal of Thrombosis and Haemostasis, Vol. 6, No. 5, pp. 877-884

Szotowski, Björn; Antoniak, Silvio; Goldin-Lang, Petra; Tran, Quoc-Viet; Pels, Klaus; Rosenthal, Peter; Bogdanov, Vladimir Y; Borchert, Hans-Hubert; Schultheiss, Heinz-Peter; Rauch, Ursula 2007. Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells. Cardiovascular research, 73 4, 806-12

Bogdanov, V.Y., Kirk, R.I., Miller, C., Hathcock, J.J., Vele, S., Gazdoiu, M., Nemerson, Y., and Taubman, M.B. 2006. Identification and Characterization of Murine Alternatively Spliced Tissue Factor Journal of Thrombosis and Haemostasis, Vol 4, No. 1, pp. 158-167

Bogdanov, Vladimir Y 2006. Blood coagulation and alternative pre-mRNA splicing: an overview. Current molecular medicine, 6 8, 859-69

Szotowski, Björn; Goldin-Lang, Petra; Antoniak, Silvio; Bogdanov, Vladimir Y; Pathirana, Delano; Pauschinger, Matthias; Dörner, Andrea; Kuehl, Uwe; Coupland, Sarah; Nemerson, Yale; Hummel, Michael; Poller, Wolfgang; Hetzer, Roland; Schultheiss, Heinz-Peter; Rauch, Ursula 2005. Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy. Journal of the American College of Cardiology, 45 7, 1081-9

Bogdanov VY, Hathcock JJ, Nemerson Y. 2004. Active Tissue Factor in Blood? Author reply. Nature Medicine, Vol. 10, No.11, p 1156

Bogdanov, Vladimir Y; Balasubramanian, Viji; Hathcock, James; Vele, Oana; Lieb, Mark; Nemerson, Yale 2003. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Nature medicine, 9 4, 458-62

Schecter, A.D., Spirn, B., Rossikhina, M., Giesen, P.L.A., Bogdanov, V.Y., Fallon, J.T., Fisher, E.A., Schnapp, L.M., Nemerson, Y., and Taubman, M.B. 2000. Release of Active Tissue Factor by Human Arterial Smooth Muscle Cells Circulation Research, Vol. 87 No.3, pp. 126-132

Bogdanov, V.Y., Poon, M., and Taubman, M.B. 1998. Platelet-Derived Growth Factor-Specific Regulation of the JE Promoter in Rat Aortic Smooth Muscle Cells The Journal of Biological Chemistry, Vol. 273 No. 38, pp. 24932-24938

Poon, M., Hsu, W.C., Bogdanov, V.Y., and Taubman, M.B. 1996. Secretion of Monocyte Chemotactic Activity by Cultured Rat Aortic Smooth Muscle Cells in Response to PDGF is Due Prodominantly to the Induction of JE/MCP-1. American Journal of Pathology, Vol. 149, No.1, pp. 307-317.

Taby, O., Rosenfield, C.-L., Bogdanov, V.Y., Nemerson, Y., and Taubman, M.B. 1996. Cloning of the Rat Tissue Factor cDNA and Promoter: Identification of a Serum-response Region Thrombosis and Haemostasis, Vol. 76, No.5, pp. 697-702