Today is Wednesday, Dec. 11, 2019

Department of Internal Medicine

Cardiovascular Health and Disease

Photo of  Michael Tranter, PhD

Michael Tranter, PhD

Assistant Professor

Education/Credentials
  • Doctoral Degree: University of Cincinnati
  • Bachelor's Degree: Rose-Hulman Institute of Technology

Research/Clinical Interests

The long-term goals of my research are to increase our understanding of the molecular mechanisms of cardiovascular disease. Within this realm, the ongoing work in the laboratory is broadly centered around post-transcriptional gene regulation in the setting of (1) pathological left ventricular hypertrophy and fibrosis, and (2) the mechanisms of cardioprotection against ischemia/reperfusion injury. My laboratory has identified human antigen R (HuR) as a new player in the development of pathological cardiac hypertrophy in response to pressure overload (e.g. chronic hypertension). A recent publication from the lab shows that HuR promotes cardiomyocyte hypertrophy downstream of p38 MAP kinase in an isolated neonatal cardiomyocyte model (Slone et al, Cellular Signaling, 2016). Using a new inducible, cardiac-specific HuR knockout mouse created by our lab, we also show that deletion of HuR in the adult heart preserves cardiac function while decreasing pathological ventricular remodeling following transverse aortic constriction (TAC), a model of hypertension-induced pathological cardiac hypertrophy. Ongoing projects in the lab are designed to identify (1) the upstream signaling mediators of HuR in hypertrophic myocytes, and (2) the downstream target genes of HuR and the mechanisms by which regulation of these targets promotes pathology. Additional projects in the lab include the role of HuR in myocardial ischemia/reperfusion injury, ischemic preconditioning, and diet-induced obesity. Finally, we are working to develop a novel drug-screening assay to allow for high-throughput screening and identification of unique small-molecule inhibitors of HuR for validation in our cell and animal models of HuR-mediated pathology.

Contact Information
  • Internal Medicine
  • Medical Sciences Building Room 6065
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-2356
  • Email trantemc@ucmail.uc.edu

Peer Reviewed Publications

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Slone, Samuel; Anthony, Sarah R; Wu, Xiaoqing; Benoit, Joshua B; Aube, Jeffrey; Xu, Liang; Tranter, Michael 2016. Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy. Cellular signalling, 28 11, 1735-1741

Kraynik, Stephen M; Gabanic, Andrew; Anthony, Sarah R; Kelley, Melissa; Paulding, Waltke R; Roessler, Anne; McGuinness, Michael; Tranter, Michael 2015. The stress-induced heat shock protein 70.3 expression is regulated by a dual-component mechanism involving alternative polyadenylation and HuR. Biochimica et biophysica acta, 1849 6, 688-96

Haar, Lauren; Ren, Xiaoping; Liu, Yong; Koch, Sheryl E; Goines, Jillian; Tranter, Michael; Engevik, Melinda A; Nieman, Michelle; Rubinstein, Jack; Jones, W Keith 2014. Acute consumption of a high-fat diet prior to ischemia-reperfusion results in cardioprotection through NF-?B-dependent regulation of autophagic pathways. American journal of physiology. Heart and circulatory physiology, 307 12, H1705-13

Millard, Ronald W; Tranter, Michael 2014. Complementary, alternative, and putative nontroponin biomarkers of acute coronary syndrome: new resources for future risk assessment calculators. Revista espan?ola de cardiologi?a (English ed.), 67 4, 312-20

Koch, Sheryl E; Tranter, Michael; Robbins, Nathan; Luther, Kristin; Singh, Umesh; Jiang, Min; Ren, Xiaoping; Tee, Trisha; Smith, Leah; Varma, Priyanka; Jones, W Keith; Rubinstein, Jack 2013. Probenecid as a noninjurious positive inotrope in an ischemic heart disease murine model. Journal of cardiovascular pharmacology and therapeutics, 18 3, 280-9

Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack 2012. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. Journal of molecular and cellular cardiology, 53 1, 134-44

Robbins, Nathan; Koch, Sheryl E; Tranter, Michael; Rubinstein, Jack 2012. The history and future of probenecid. Cardiovascular toxicology, 12 1, 1-9

Tranter M, Liu Y, He S, Gulick J, Ren X, Robbins J, Jones WK, Reineke TM. 2012. Delivery of NF-κB oligodeoxynucleotide decoys via glycopolymer vehicles affords therapeutic infarct size reduction in vivo. Molecular Therapy, 20 3, 601

Tranter, Michael; Liu, Yemin; He, Suiwen; Gulick, James; Ren, Xiaoping; Robbins, Jeffrey; Jones, W Keith; Reineke, Theresa M 2012. In vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo. Molecular therapy : the journal of the American Society of Gene Therapy, 20 3, 601-8

Tranter, Michael; Helsley, Robert N; Paulding, Waltke R; McGuinness, Michael; Brokamp, Cole; Haar, Lauren; Liu, Yong; Ren, Xiaoping; Jones, W Keith 2011. Coordinated post-transcriptional regulation of Hsp70.3 gene expression by microRNA and alternative polyadenylation. The Journal of biological chemistry, 286 34, 29828-37

Wilhide, Michael E; Tranter, Michael; Ren, Xiaoping; Chen, Jing; Sartor, Maureen A; Medvedovic, Mario; Jones, W Keith 2011. Identification of a NF-?B cardioprotective gene program: NF-?B regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion. Journal of molecular and cellular cardiology, 51 1, 82-9

Tranter, Michael; Ren, Xiaoping; Forde, Tiffany; Wilhide, Michael E; Chen, Jing; Sartor, Maureen A; Medvedovic, Mario; Jones, W Keith 2010. NF-kappaB driven cardioprotective gene programs; Hsp70.3 and cardioprotection after late ischemic preconditioning. Journal of molecular and cellular cardiology, 49 4, 664-72

Kwon, Ohwon; Tranter, Michael; Jones, W Keith; Sankovic, John M; Banerjee, Rupak K 2009. Differential translocation of nuclear factor-kappaB in a cardiac muscle cell line under gravitational changes. Journal of biomechanical engineering, 131 6, 064503

Tranter M and Jones WK. 2008. Anti-Inflammatory effects of HO-1 activity in vascular endothelial cells. Free Radical Biology and Medicine., 44 3, 261

Tranter, Michael; Jones, W Keith 2008. Anti-inflammatory effects of HO-1 activity in vascular endothelial cells, commentary on "Carbon monoxide donors or heme oxygenase (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death". Free radical biology & medicine, 44 3, 261-3

Smiley, Dia; Smith, Margaret A; Carreira, Vinicius; Jiang, Min; Koch, Sheryl E; Kelley, Melissa; Rubinstein, Jack; Jones, W Keith; Tranter, Michael . Increased fibrosis and progression to heart failure in MRL mice following ischemia/reperfusion injury. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 23 6, 327-34