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Department of Environmental Health

Risk Science Center (RSC)

UC Risk Science Center

The Science of Public Health Protection

The Risk Science Center conducts our work at the intersection of science and health protection. Chemicals are an important part of our daily lives. Some chemicals are essential to a healthy life, but exposure to chemicals may also present health risks. We study the way our bodies interact with the chemicals around us to determine the nature and extent of health risks. We are dedicated to scientific collaboration and transparency in support of public health protection and strive for broad communication of risk science by providing risk managers, legislators, and ordinary citizens with the toxicology information they need to make important decisions about chemical safety.

Our Expertise Includes

  • Human Health Risk Assessment
  • Pharmaceutical Support
  • Peer Review & Consultation
  • Site & Product Assessment
  • Risk Assessment Training
  • Ecological Risk Assessment
  • Occupational Risk & Exposure
  • Green Chemistry
  • Risk Methods Development

Click here for a detailed description of each expertise (pdf).

Human Health Risk Assessment

HHRA

The Risk Science Center scientists combine a practitioner’s knowledge of the issues and pitfalls involved in the development of human health risk assessments, together with cutting-edge toxicology expertise, to develop state-of-the-science assessments. Our research, aimed at improving risk assessment methods particularly in the areas of dose-response and mode of action, further enhance our analyses. In solving risk problems for a diverse array of government and private sponsors, we apply a collaborative philosophy that emphasizes partnership building, allowing us to expand our pool of expertise, build on multiple perspectives, and ensure the use of the best science. These strengths form the basis for our development of independent and science-driven analyses for a range of risk assessment products such as screening-level assessments, dossiers for HPV and REACH, occupational assessments, and in-depth evaluations considering mechanistic data and using sophisticated modeling techniques.

 

For more information, contact Dr, Lynne Haber(lynne.haber@uc.edu; 513-558-7631).

Peer Review & Consultation

Engaging outside experts to review risk assessments and methods can help insure high quality and scientifically defensible work products and results. Government agencies, NGOs and industry recognize the value added by expert peer review and the Risk Science Center is a world leader in providing independent expert review for all types of risk assessment documents and activities. We provide a variety of opportunities and services to engage expert peers, including in-person panel meetings, webcasts and webinars; letter reviews; workshops to develop risk values or methods; and in-house technical reviews.

PR&CFor more information contact Ms. Jacqueline Patterson (jacqueline.patterson@uc.edu; 513-558- 7908).

Risk Assessment Training


RAT

The Risk Science Center is committed to working with the public to improve knowledge and understanding of risk assessment issues. Our education goal is to share our knowledge with others who are interested in learning risk assessment through developing our risk assessment training courses suitable to a variety of audiences including industry, government, the legal community, academia, nonprofits, and citizens' groups. We strive to make risk issues and the underlying science understandable to the intended audience and skill level.

For more information, contact Dr, Lynne Haber (lynne.haber@uc.edu; 513-558-7631).

Occupational Risk & Exposure

 

Although a number of U.S. organizations develop occupational exposure limits (OELs), much of the effort has focused on a relatively small subset of high volume chemicals, or those with particularly severe toxic endpoints. As a result, many workers are exposed to substances for which no guidance on acceptable exposure levels has been developed.The shortfall inOR&E protection of worker health due to the limited number of OELs suggests that active participation by the Risk Science Center in this area is consistent with our mission to use the best available science for development of risk values to protect public health. The Center's goal is to work cooperatively with other organizations’ efforts to see that more OELs are developed and take full advantage of advances in risk assessment methods. The Risk Science Center works to support OEL development through two distinct programs: development of sound OELs by Center staff, and organizing independent peer reviews of values developed by others.

For more information, contact Dr. Andy Maier (maierma@ucmail.uc.edu; 513-558-2407)

Risk Methods Development

RM&D

The field of risk assessment is changing rapidly as the "omics" revolution and the burgeoning field of molecular toxicology provide a wealth of data that were not traditionally available. The Risk Science Center's research seeks to enhance the use of data on mode and mechanism of action to inform qualitative and quantitative aspects of risk assessment. We do this by designing targeted studies and decision frameworks to address key MOA questions, incorporating biomarker data to extend the dose-response curve using advanced PBPK and BBDR modeling approaches, and developing approaches to evaluate health risk assessment for potentially-susceptible populations and other areas of uncertainty in risk assessment. 

 

For more information, contact Dr, Lynne Haber (lynne.haber@uc.edu; 513-558-7631).

 

 

Pharmaceutical Support

PharmaThe Risk Science Center is a world leader in deriving safe dose estimates for human health. At the Risk Science Center, pharmaceutical services build on our strength as a leader in toxicological risk assessment. Whether you need an Occupational Exposure Limit set for an active pharmaceutical ingredient, are concerned about the safety implications of an impurity in your raw material or finished product, or are not sure how a regulatory guidance applies to your particular situation, we have the expertise to meet your needs. Our highly qualified team includes occupational physicians, industrial hygienists, pharmacists, and board-certified toxicologists.

For more information, contact Dr. John Reichard (reichajf@ucmail.uc.edu; 513-558-7946)


Site & Product Assessment

S&PThe Risk Science Center provides integrated toxicology support for product safety evaluation and characterization of environmental site-related risks through our extensive network of international experts in exposure modeling.

For more information, contact Dr. Andy Maier (maierma@ucmail.uc.edu; 513-558-2407)

 

Ecotoxicology & Ecological Risk Assessment

Eco&Eco

The Risk Science Center has an expanded suite of ecological and environmental sciences services, complementing our strong historical reputation in health risk assessment and industrial hygiene. Our staff includes scientists with broad experience in ecotoxicology, environmental fate, and ecological risk and hazard assessment of chemical ingredients, products and byproducts. We provide our private and public sector sponsors with fully integrated health and environmental services to support safe, responsible, and compliant chemical characterization, formulation, and management.

 

Green Chemistry

GreenAt the Risk Science Center, we embrace the principles of Green Chemistry to help our sponsors design products and processes that reduce or eliminate the generation of hazardous substances. We offer systematic approaches to weighing comparative health and environmental risks, to help prevent waste, design safer products, and minimize the potential for accidents.

For more information, contact Dr, Lynne Haber (lynne.haber@uc.edu; 513-558-7631)