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 Abdel-Malek CV

Curriculum Vitae


ZALFA A. ABDEL-MALEK, Ph.D. OFFICE ADDRESS

Department of Dermatology

Univ of Cincinnati College of Medicine Phone: (513) 321-6469 231 Albert Sabin Way

Cincinnati, Ohio 45267-0592

Phone: (513) 558-6242 FAX: (513) 558-0198

Email: abdelmza@email.uc.edu

Research Interests: Hormonal regulation of cellular proliferation and differentiation Mechanisms for cutaneous carcinogenesis

Epidermal cell-cell interaction


EDUCATION


    1. Postdoctoral Fellow (Mentor: James Nordlund, M.D.)

Department of Dermatology

University of Cincinnati College of Medicine

Cincinnati, Ohio


1984 Ph.D., General Biology (Advisor: Mac Hadley, Ph..D.; Co-advisor: Frank

Meyskens, M.D.)

Ph.D. Thesis: "Regulation of Phenotypic Expression and Proliferation of 891 Melanoma Cells by Potent Hormone Analogues"

University of Arizona

Tucson, Arizona


1980 General Biology (Advisor: Mac Hadley, Ph.D.)

University of Arizona Tucson, Arizona


1974 B.S., Biology

American University of Beirut

Beirut, Lebanon





POSITIONS


2002- present Research Professor

Department of Dermatology, University of Cincinnati College of Medicine Cincinnati, Ohio


1996 -Present Member of the Center of Environmental Genetics

Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio


1993 -Present Research Associate Professor of Dermatology

Department of Dermatology, University of Cincinnati College of Medicine Cincinnati, Ohio


1993 -2002 Joint Appointment as Associate Professor of Cell Biology, Neurobiology, and Anatomy

Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine Cincinnati, Ohio


1987 -1993 Assistant Professor of Dermatology

Department of Dermatology, University of Cincinnati College of Medicine Cincinnati, Ohio


1992-1993 Joint Appointment as Assistant Professor of Anatomy and Cell Biology

Dept of Anatomy & Cell Biology, Univ. of Cincinnati College of Medicine Cincinnati, Ohio


1985 -1987 Post-Doctoral Fellow, Department of Dermatology

University of Cincinnati College of Medicine, Cincinnati, Ohio.


1983 -1984 Research Associate

Department of Ecology and Evolutionary Biology and the Cancer Center University of Arizona, Tucson, Arizona


1981 -1983 Research Assistant, The Cancer Center University of Arizona, Tucson, Arizona


1979 -1981 Teaching Assistant, Department of General Biology University of Arizona, Tucson, Arizona


1974 -1978 Laboratory Assistant

Hematology Section of the Department of Clinical Pathology American University Medical Center, Beirut, Lebanon


SCIENTIFIC SOCIETIES

2003- Present Vice-President of the Federation of Pigment Cell Societies

2002- Present President of Pan American Society for Pigment Cell Research

1999 -2001 President-elect of Pan American Society for Pigment Cell Research

1996 -Present American Society for Photobiology, Member

1992 -1995 Council Member of Pan American Society for Pigment cell Research

1989 -Present American Association for the Advancement of Science, Member

1988 -Present Pan American Society for Pigment Cell Research, Member

1986 -Present International Pigment Cell Society, Member 1986 -Present Society for Investigative Dermatology


EDITORIAL ACTIVITIES AND REVIEW BOARDS


  1. Member of Special Emphasis Panel Group, NIEHS

  1. Reviewer of Pilot Projects for the Center for Environmental

Genetics

2002 Reviewer of grants for the State of New Jersey

2000 -Present Associate Editor for Pigment Cell Research

2000 -2002 Member of the Dermatology Foundation Medical and Scientific Committee

1999 Reviewer of grants for the Ohio Cancer Research Associates

1996 Ad-hoc Reviewer for Radiation Study Section, National Institute of Environmental Health Sciences

1990 Reviewer of grants for the Arizona Disease Control Center

1988 -Present Reviewer for Journal of Investigative Dermatology

1988 -1989 Reviewer of Veterans Administration Grants

1987 -Present Reviewer for Pigment Cell Research


GRANTS


National Institutes and Foundations


    1. National Cancer Institute (RO1): Discovery of �-MSH Analogs for Skin

Cancer Prevention

4/01/05-3/31/10 ($1,372,235 Direct Cost) Pending


    1. Dermatology Foundation Research Grant:Elucidation of the Role

of the Melanocortin 1 Receptor Gene as a Melanoma Susceptibility

Gene

7/01/04-6/30/05 ($20,000 Direct Cost) (Co-Investigator)

(PI: Sancy Leachman, M.D., Ph.D., Department of Dermatology;

Huntsman Cancer Center, University of Utah, Salt Lake City, Utah)


2003-2008 National Institute for Environmental Health Sciences (RO1): Signaling Pathways for UV -Induced Melanogenic Response (Competitive Renewal) 4/01/03-3/31/08 ($1,068750 Direct Cost)


2003-2006 Johnson and Johnson Skin Research Training Grant: a-Melanocortin and Endothelin-1 Promote Human melanocyte Survival by Inhibiting Apoptosis In Response to Ultraviolet Radiation

1/1/03-12/31/06 ($145,000 Direct Cost)


1998 -2002 National Institute of Environmental Health Sciences (RO1):Signaling Pathways for UV-Induced Melanogenic Response 4/01/98 -3/30/02 ($473,686 Direct Cost)


1996 -1997 The Skin Cancer Foundation Grant: Skin Cancer Risk: Role of Melanin, p53 and Apoptosis

3/01/96 -2/28/97 ($10,000 Direct Costs)


1995 -1996 Dermatology Foundation Grant: Melanotropic Hormones as Regulators of Human Pigmentation

7/01/95 -6/30/96 ($10,000 Direct Cost)

1995 -1999 National Institute of Environmental Health Sciences (RO 1): Response of Melanocytes to UV Light Is Mediated by MSH 4/01/95 -3/31/99 ($405,759 Direct Costs)


1992 -1993 National Neurofibromatosis Foundation Grant: Cellular and Biochemical Analysis of the Cutaneous Pigmentary Abnormalities in NF-1

7/01/92 -6/30/93 ($45,500 Direct costs)


1992 Dermatology Foundation Grant: Heterogeneous Pigmentation of Human Melanocytes: The Influence of Regulatory Enzymes and Autocrine Factors 1/01/92 -12/30/92 ($10,000 Direct costs)


1989 -1992 National Vitiligo Foundation Program Project (Co-Investigator): A program Project to Find the Cause(s) and Cure(s) for Vitiligo

11/01/89 -10/31/92 ($90,000)


1986 -1987 Westwood Pharmaceutical: Lawrence N. Gelb Research Foundation Fellowship (Dermatology Foundation Fellowship): Effects of Vitamin D on Melanogenesis and Proliferation of S91 Melanoma

1/01/86 -12/30/87 ($20,000)


1985 -1986 Del E. Webb Foundation: Drug Conjugated Melanotropins, A Novel Approach for Melanoma Treatment

8/01/85 -7/31/86 ($20,000)




University and Local Foundations


    1. Dean’s Discovery Fund: Design and Evaluation of �-Melanocyte

Stimulating Hormone Agonists that Can Be Used Clinically to Prevent

Melanoma

7/01/04-6/30/05 ($30,000 Direct Cost)


    1. Center for Environmental Genetics (Pilot Project): Mutations in the

Melanocortin 1 Receptor gene Increase the Risk for Skin Cancer by

Disrupting DNA Repair Pathways

4/01/04-3/31/05 ($25,000 Direct Cost ) (Co-Investigator; PI: Dorothy

Supp, Ph.D., Department of Surgery, University of Cincinnati)

2002-2003 Center for Environmental Genetics (Pilot Project): Loss of Function

Mutations in the Melanocortin 1 Receptor Gene Sensitize Melanocytes to the Photodamaging Effects ofUV Radiation

4/01/02-03/31/03 ($25,000 Direct Cost)


2001-2003 Ohio Cancer Research Associates: Analysis of the Photobiological Effects of UV A on Normal Human Melanocytes from Different Pigmentary Phenotypes: Role of Oxidative Stress

7/01/2001-6/30/2003 (45,000 Direct Cost)


1999 -2000 Center for Environmental Genetics (pilot Project): Differential Responses of Human Melanocytes with Different Constitutive Melanin Content to Ultraviolet A Exposure

4/01/99-03/31/00 ($29,000 Direct Cost)


1997 -1998 Ohio Cancer Research Associates: Elucidation of the Role of the MCl Receptor Gene as a Tumor Susceptibility Gene

7/1/97 -6/30/98 ($18,182 Direct Cost)


1993 -1995 Ohio Cancer Research Associates: Protective Role of Melanin Against Photocarcinogenesis

7/01/93 -6/30/95 ($36,360 Direct costs)


1993 -1994 Center for Environmental Genetics (Pilot Project): Characterization of Individuals with High Risk to UVR Induced DNA Damage and Photocarcinogenesis Using Cutaneous Pigmentation as a Criterion 4/01/93 -3/30/94 ($25,000 Direct costs)


1992 -1993 American Cancer Society Institutional Research Grant: Heterogeneity of Human Melanocytes: Its Relevance to Susceptibility to UVBR and Melanoma Formation

9/01/92 -8/30/93 ($10,000 Direct costs)


1987 –1988 NIH Biomedical Research Support Grant Program: Hormones of Epidermal Origin Modulate the Responsiveness of Cloudman Melanoma Cells to Melanogenic Agents

4/01/87 -3/31/88 ($10,300)


Industrial Grants and Contracts


    1. Johnson and Johnson Skin Research Laboratories: Establishing Autologous

Cultures of Human Keratinocytes and Melanocytes from Donors with Different Ethnic Backgrounds�. ($9,500 Direct Cost).



2001-2002 The Procter and Gamble Company: Towards Understanding the Mechanism of Hypopigmentation of Human Skin by CFOO 1

6/01/01-5/31/02 ($19,500 Direct Cost).


2001 Unilever: Establishing Normal Human Melanocyte Cultures from Adults of Different Ethnic Groups and Pigmentary Phenotypes

2/01/01- 8/31/01 ($19,025 Direct Cost).


2001-2002 POLA Chemical Industries, Inc.: Implications of MC1R Variants on the Responses of Human Melanocytes to Melanocortins and UV Radiation

5/01/01-4/30/02 ($20,000).


1999 - 2000 The Procter and Gamble Company: Evaluation of the Effects of a compound in Primary Human Melanocytes

11/01/99 -5/01/00 ($5000 Direct Cost).


1998 – 2000 POLA Chemical Company: Design and Evaluation of �-Melanotropin Antagonists and Agonists Intended for Human Use

01/01/98 -12/31/00 ($150,000 Direct Cost).


1996 -1997 Shiseido Co. Ltd. Training Contract

9/1/96 -2/1/97 ($32,000 Direct Cost).


  1. Shiseido Co. Ltd.: Mechanisms of Action and Interaction of Melanotropic Peptides and UV light on Human Melanocytes

/1/94 -3/31/95 ($45,917 Direct Cost).



Awards


1990 The Vitiligo Research Award sponsored by the Skin Disease Society and awarded by the PanArnerican Society for Pigment Cell Research


DEPARTMENTAL ACTIVITIES and COMMITTEES


2000 -2003 Chairman, Appointment, Reappointment, Promotion and Tenure Committee

1999 -Present Leader of Basic Science Journal Club

  1. Finance Committee

1990 -Present Reappointment, Promotion and Tenure Committee

1990 Committee to review the curriculum of the Dermatology Elective 1989 –

1991 Organizer of the P&G Lectureship Series

1989 -1990 Committee to screen Dermatology Residency applications


UNIVERSITY COMMITTEES


2000 -2002 Admissions Committee, Adjunct Member

1999 -2002 Medical Student Research Committee

1998 -2001 Committee on Research

1998 -2000 Admissions Committee

1997 Ad Hoc Nominations Committee

1997 Search Committee for Chairman of Dermatology

1998 Referee for the Medical Student Summer Research Presentations


NATIONAL and INTERNATIONAL COMMITTEES


2003-Present Program Committee for the International Federation for Pigment Cell Societies Conference


2003 Program Committee for the 12th Annual Meeting for the pan American

Society for Pigment Cell Research

    1. Program Committee for the 17th International Pigment Cell Conference

2000-2002 Scientific Committee, Society for Investigative Dermatology

2000 -2001 Program Committee for the 10th Annual Meeting for the Pan American Society for Pigment Cell Research, Minneapolis, MN, June 2001.

1997 Program Committee for the 7th Annual Meeting for the PanArnerican Society for Pigment Cell Research. Providence, RI, June, 1997.

1993 -1995 Chairperson for the Newsletter Committee for the PanAmerican Society for Pigment Cell Research

1992 Program Committee for the 4th Annual Meeting of the PanAmerican Society for Pigment Cell Research. Cincinnati, OH, June, 1992.

1992 Ad Hoc Nominations Committee for the PanAmerican Society for Pigment Cell Research


ORIGINAL PUBLICATIONS


1. Kadekaro AL, Kanto H, Kavanagh RJ, Schwemberger S, Cornelius J, Babcock G, Shertzer HG, Scott G, Abdel-Malek ZA. The role of �-Melanocortin and endothelin-1 in promoting survival and genomic stability of human melanocytes following UV-irradiation. To be submitted to Cancer Res, 2004.


2. Moro 0, Pereira E, Kadekaro AL, Kavanagh R, Swope VB, Boyce ST, Abdel-Malek ZA. Ultraviolet B radiation activates a common signaling pathway that regulates the proliferation and survival of human keratinocytes, me1anocytes and fibroblasts. Submitted to Pigment Cell Research, 2004.


3. Yamaguchi Y, Itami S, Watabe H, Yasumoto K, Abdel-Malek, ZA, Kubo T, Rouzaud F, Tanemura A, Ysohikawa K, Hearing VJ. Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by plamoplantar fibroblasts inhibits melanocytes growth and differentiation. J. Cell Biol., 165:275-285, 2004.


4. Scott MC, Suzuki I, Abdel-Malek ZA. Transcriptional regulation of the human melanocortin 1 receptor gene in epidermal melanocytes by paracrine and endocrine factors, and by UV radiation. Pigment Cell Res. 15:433439,2002.


5. Scott MC, Wakamatsu K, Ito S, Kobayashi N, Groden J, Kavanagh R, Takakuwa T, Virador V, Hearing VI, Abdel-Malek ZA. Implications of mutations in the human melanocortin 1 receptor gene on the responses of melanocytes to �-melanocyte stimulating hormone and ultraviolet radiation. J. Cell Science 115:2349- 2355, 2002.


6. Tada A, Elizabeth Pereira, Dana Beitner-Johnson, Abdel-Malek Z. Mitogen and ultraviolet-induced signaling pathways in normal human melanocytes. J.lnvest. Dermatol. 118:316-322,2002.


7. Virador VM, Muller Jacqueline, Wu X, Abdel-Malek ZA, Yu Z, Ferrans VI, Kobayashi N, Wakamatsu K, Ito S, Hammer JA, Hearing VI. Influence of �-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of me1anosomes to keratinocytes. F ASEB J. 16: 105-107, 2002.


8. Virador V, Matsunaga N, Matsunaga J, Valencia J, Oldham RJ, Kameyama K, Peck GL, Ferrans VI, Vieira WD, Abdel-Malek ZA, Hearing VI. Production of melanocyte-specific antibodies to human melanosomal proteins: expression patterns in normal human skin and in cutaneous pigmented lesions. Pigment Cell Res. 14:289-297,2001.


9. Abdel-Malek ZA, Scott C, Furumura M, Lamoreux L, Ollmann M, Barsh G, Hearing V. The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein in mammalian melanocytes. J. Cell Science 114:10190-1024,2001.


10. Yang F, Abdel-Malek Z, Boissy RE. Effects of commonly used mitogens on the cytotoxicity of 4-tertiary butylphenol to human melanocytes. In Vitro Cell. Dev. BioI. 35: 566-570, 1999.


11. Tada A, Suzuki I, 1m S, Davis MB, Cornelius J, Babcock G, Nordlund JJ, Abdel-Malek ZA: Edothe1in-1 is a paracrine factor that modulates melanogenesis of human melanocytes and participates in their response to ultraviolet light. Cell Growth Diff9:575-584, 1998.


12. Can G, Abdel-Malek Z Porter-Gill PA, Gill P, Boyce S, Grabowski GA, Nordlund J, Farooqui J.

Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture. J Invest Dermatoll11:485491, 1998.


13. Im S, Moro 0, Medrano EE, Cornelius J, Babcock G, Nordlund JJ, Abdel-Malek ZA: Activation of the cAMP pathway by �-melanotropin mediates the response of human melanocytes to UVB radiation. Cancer Res 58:47-54, 1998.


14. Scott G, Cassidy L, Abdel-Malek Z, �-Melanocyte stimulating hormone and endothelin-l have opposing effects on melanocyte adhesion, migration and pp 125FAK phosphorylation. Exp Cell Res 237: 19-28, 1997.


15. Suzuki I, Tada A, Ollmann MM, Barsh GS, Im S, Lamoreux ML, Hearing VB, Nordlund JJ and Abdel- Malek ZA: Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to �- melanotropin. J Invest Dermatol 108: 83 8-842, 1997.


16. Sakai C, Ollmann M, Kobayashi T, Abdel-Malek Z, Muller J, Vieira WD, Imokawa K, Barsh GS, Hearing VI: Modulation of murine melanocyte function in vitro by agouti signal protein. EMBO J 16:3544-3552, 1997.


17. Suzuki I, Cone RD, Im S, Nordlund JJ, Abdel-Malek Z: Binding of melanotropic hormones to the MC1 receptor on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 137: 1627-1633, 1996.


18. Barker D, Dixon K, Medrano EE, Smalara D, Im S, Mitchell D, Babcock G, Abdel-Malek ZA: Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation. Cancer Res 55:4041-4046, 1995.


19. Medrano EE, Im S, Yang F, Abdel-Malek ZA: UVB light induces GI arrest in human melanocytes by prolonged inhibition of pRb phosphorylation associated with long term expression of the protein p21 Waf-I/SD- /Cip-1 protein. Cancer Res 55:4047-4052, 1995.


20. Abdel-Malek ZA, Swope VB, Suzuki I, Akcali C, Harriger MD, Boyce ST, Urabe K, Hearing VI: The mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci USA 92:1789-1793,1995.


21. Swope VB, Medrano EE, Smalara D, Abdel-Malek ZA: Long term proliferation of human melanocytes is supported by the physiologic mitogen �-melanotropin, endothelin-l, and basic fibroblast growth factor. Exp Cell Res 217:453-459,1995.


22. Abdel-Malek Z, Swope V, Smalara D, Babcock G, Dawes S, Nordlund J: Analysis of the UV induced melanogenesis and growth arrest of human melanocytes. Pigment Cell Res 7:326-332, 1994.


23. Zhao H, Boissy YL, Abdel-Malek Z, King RA, Nordlund JJ, Boissy RE: On the analysis of the pathophysiology of Chediak-Higashi syndrome: Defects expressed by cultured melanocytes. Lab Invest 71:25-34,1994.


24. Abdel-Malek ZA, Swope VB, Nordlund JJ, Medrano EE: Proliferation and propagation of human melanocytes in vitro are affected by donor age and anatomical site. Pigment Cell Res 7: 116-122, 1994.


25. Swope VB, Sauder DN, McKenzie RC, Sramkoski RM, Krug KA, Babcock GF, Nordlund JJ, Abdel-Malek ZA: Synthesis of IL-l� and IL-1� by normal human melanocytes. J Invest Dermatol l02:749-753, 1994.


26. Abdel-Malek Z, Swope V, Boissy R, Zhao H, Nordlund JJ: Contribution of melanogenic enzymes to the heterogeneous pigmentation of human melanocytes. J Cell Sci 106:1323-1331, 1993.


27. Boyce ST, Medrano EE, Abdel-Malek Z, Supp AP, Dodick JM, Nordlund JJ, Warden GD: Pigmentation and inhibition of wound contraction by cultured skin substitutes with adult melanocytes after transplantation to athymic mice. J Invest Dermatol 100:360-365, 1993.


28. Ghanem G, Loir B, Hadley M, Abdel-Malek Z, Libert A, Del Marmol V, Lejeune F, Lozano J, Garcia- Borron J-C: Partial characterization of IR-�-MSH peptides found in melanoma tumors. Peptides 13:989- 994,1992.


29. Abdel-Malek Z, Swope VB, Pallas J, Krug K, Nordlund JJ: Mitogenic, melanogenic and cAMP responses of cultured neonatal human melanocytes to commonly used mitogens. J Cell Physiol150:416-425, 1992.


30. Plews PI, Abdel-Malek ZA, Doupnik CA, Leikauf GD: Endothe1in stimulates chloride secretion across canine tracheal epithelium. AmJ Physio1261:L188-L194, 1991.


31. Swope VB, Abdel-Malek ZA, Kassem L, Nordlund JJ: Interleukins 1� and 6 and tumor necrosis factor-� are paracrine inhibitors of human melanocyte proliferation and melanogenesis. J Invest Dermatol 96:180-185,1991.


32. Nordlund JJ, Abdel-Malek ZA, Boissy RE, Rheins LA: Historical review of pigment cell biology. J Invest Dermato192(suppl):53-60, 1989.


33. Abdel-Malek ZA, Swope VB, Trinkle LS, Nordlund JJ: Stimulation of Cloudman melanoma tyrosinase activity occurs predominantly in G2 phase of the cell cycle. Exp Cell Res 180:198-208, 1989.


34. Swope VB, Abdel-Malek ZA, Sauder D, Nordlund JJ: A new role for epidermal cell thymocyte activating factor (ETAF) as an antagonist for distinct epidermal cell function. J Immunol142:943-949, 1989.


35. Nordlund JJ, Amornsiripanitch S, Rheins LA, Abdel-Malek ZA, Boissy RE, Bell M: The role of the melanocyte in epidermal inflammatory/immune response. Pigment Cell Res 1 (Suppl 1):101-112, 1988.


36. Trinkle L, Swope VB, Abdel-Malek ZA, Nordlund JJ: Differentiation of mitotic melanoma cells from G2 cells and their isolation by use of 5-bromo-2'deoxyuridine and propidium iodide. Cytometry 9:432-435,

1988.


37. Abdel-Malek ZA, Swope VB, Trinkle LS, Ferroni EN, Boissy RE, Nordlund JJ: Alterations of the Cloudman melanoma cell cycle by prostaglandins Et and E2 using a 5-bromo-2'-deoxyuridine method of DNA analysis. J Cell Physiol136:247-256, 1988.


38. Abdel-Malek ZA, Ross R, Pike J, Trinkle L, Swope V, Nordlund JJ: Hormonal effects of vitamin D3 and its hydroxylated metabolites on epidermal melanocytes. J Cell Physiol136:273-280, 1988.


39. Levine N, Lemus AL, Wood SH, Abdel-Malek ZA, Al-Obeidi F, Hruby VI, Hadley ME: Stimulation of follicular melanogenesis in the mouse by topical and injected me1anotropins. J Invest Dermato1 89:269-273,

1987.


40. Abdel-Malek ZA, Swope VB, Amornsiripanitch N, Nordlund JJ: In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandin. Cancer Res 47 :3141-3146, 1987.


41. Sugg EE, Cody WL, Abdel-Malek Z, Hadley ME, Hruby VJ: D-isomeric replacements within the 6-9 core sequence of Ac-[Nle4]-a-MS&II-NH2: A topological model for the solution conformation of a- me1anotropin. Biopo1ymers 25:2029-2042,1986.


42. Abdel-Malek ZA, Kreutzfeld KL, Hadley ME, Bregman MD, Hruby VJ, Meyskens FL, Jr: Long-term and residual melanotropin-stimulated tyrosinase activity in S91 melanoma cells is density dependent. In Vitro Cell Dev Bioi 22:75-81, 1986.


43. Abdel-Malek ZA, Hadley ME, Bregman MD, Meyskens FL, Hruby VJ: Actions of melanotropins on melanoma cell growth in vitro. J Natl Cancer Inst 76:857-863, 1986.


44. Abdel-Malek ZA, Kreutzfeld KL, Marwan MM, Hadley ME, Wilkes BC, Hruby VJ: Prolonged stimulation of S91 melanoma tyrosinase by [Nle4, :D-Phe7-substituted �-melanotropins. Cancer Res 45:4735-4740, 1985.


45. Hadley ME, Abdel-Malek ZA, Kreutzfeld KL, Marwan MM, Hruby VJ: [Nle4, :D-Phe7-�-MSH: A superpotent melanotropin that "irreversibly" activates melanoma tyrosinase. Endocr Res 11: 157-170, 1985.


46. Marwan MM, Abdel-Malek ZA, Kreutzfeld KL, Castrucci AM, Hadley ME, Wilkes BC, Hruby VJ: Stimulation of S91 melanoma tyrosinase activity by superpotent a-melanotropins. Mol Cell Endocrinol 41:171-177,1985.


47. Bregman MD, Abdel-Malek ZA, Meyskens FL, Jr: Anchorage-independent growth of murine melanoma in serurmless media is dependent on insulin or melanocyte-stimulating hormone. Exp Cell Res 157:419-428, 1985.


REVIEWS and BOOK CHAPTERS


1. Rouzaud, F. Kakekaro AL, Abdel-Malek ZA, Hearing VJ. MC1R and the Response of Melanocytes to Ultraviolet Radiation. Mutation Res. In Press, 2004.



2. Abdel-Malek ZA, Kadekaro AL, Pipitone MA, Mutasim DF. Skin Cancer Tumors, Epidemiology, Clinical Manifestations, Genetic and Molecular Aspects. In: Moleculr Carcinogenesis (Landolph J and Warshawsky D, Eds.). CRC Press, In Press, 2004.


3. Kadekaro AL, Kavanagh RJ,Wakamatsu K, Ito S, Pipitone MA, Abdel-Malek, ZA. Cutaneous Photobiology. The Melanocytes Vs. the Sun: Who Will Win the Final Round? Pigment Cell Res. 16:434-447, 2003


4. Kadekaro AL, Kanto H, Kavanagh R, Abdel-Malek ZA. Significance of the Melanocortin 1 Receptor in Regulating Human melanocyte Pigmentation, Proliferation and survival. Proceedings of the New York Academy of Science, Roger Cone, ed. 2003, pp. 359-365.


5. Abdel-Malek, ZA.. Applying the Basic Knowledge about Regulation of Pigmentation towards Development of Strategies for Cutaneous Hypopigmentation. J. Society of Cosmetic Scientists of Korea, 28: 12-25,2002.


6. Abdel-Malek Z. Role of the Agouti and Mahogany in the Control of Melanogenesis. Proceedings of the International Workshop on Molecular Mechanisms of Tanning. J. P. Ortonne, (eds.), Martin Dunitz, Ltd., 2002, pp. 151-161.


7. Seeley R, Abdel-Malek ZA. Melanocortin Receptors. In: Encyclopedia of Molecular Medicine, Creighton TE (ed). John Wiley and Sons, Inc., 2002, pp.2035-2037.


8. Abdel-Malek ZA. Melanins and Photoprotection. In: Photobiology for the 21st Century, Presentations of the 13th International Congress on Photobiology. Coohill TP and Valenzeno DP (eds). Valdenrnar Publishing Company, Kansas City, KS, 2001, pp.61-68.


9. Abdel-Malek ZA. The Melanocortin Receptors, Their Functions and Regulation by Physiological Agonists and Antagonists. Cellular and Molecular Life Sciences 58:434-441, 2001.


10. Abdel-Malek Z, Scott MC, Suzuki I, Tada A, 1m S, Lamoreux L, Ito S, Barsh G, hearing V. The Me1anocortin-1 Receptor Is a Key Re~lator of Human Cutaneous Pigmentation. Pigment Cell Res., Supplement. Proceedings of the 171 International Pigment Cell Conference, Pigment Cell Research, 13 (Suppl.8):156-162,2000.


11. Abdel-Malek ZA. Regulation of the mouse and human MC1-R. In: The Melanocortin Receptors, Cone RD (ed). Humana Press, Totowa, NI, 2000, pp.521-536.


12. Abdel-Malek Z, Suzuki I, Tada A, 1m S, Scott MC, Akcali C. The Melanocortin-l Receptor and Human Pigmentation. In: Cutaneous Neuroimmunomodulation. The Proopiomelanocortin System, Luger T A, Paus R, Lipton IM, Slominski AT, (eds.) Annals of the New York Academy of Science 885:117-133,1999.


13. Suzuki I, 1m S, Tada A, Scott C, Akcali C, Davis MB, Barsh G, Hearing V, Abdel-Malek ZA. Participation of the melanocortin-1 receptor in the UV control of pigmentation. Proceedings of the 471h Annual Montagna Symposium on the Biology of the Skin. I Invest Dermato1, 4:29-34, 1999.


14. Abdel-Malek ZA: Regulation of human pigmentation by ultraviolet light and by endocrine, paracrine and autocrine factors. In: The Pigmentary System. Physiology and Pathophysiology, Nordlund II, Boissy RE, Hearing VI, King RA, Ortonne IP (eds.). Oxford University Press, New York, 1998. pp. 115-122.


15. Abdel-Malek ZA: Advances in long term maintenance of normal human melanocytes in culture. In: The Pigmentary System. Physiology and Pathophysiology, Nordlund II, Boissy RE, Hearing VI, King RA, Ortonne JP (eds). Oxford University Press, New York, 1998. pp. 159-163.


16. Furumura M, Sakai C, Abdel-Malek Z, Barsh GS and Hearing VI: The interaction of agouti signal protein and melanocyte stimulating hormone to regulate melanin formation in mammals. Pigment Cell Res 9: 191- 203, 1996.


17. Leikauf GD, Abdel-Malek ZA, Swope VB, Doupnik CA, Nordlund II: Constitutive biosynthesis of 12- hydroxy-5,8,10,14-eicosatetraenoic acid and 6-keto prostaglandin Fl� by human me1anocytes and Cloudman S91 melanoma cells. In: Prostaglandins, Leukotrienes and Cancer, Hammerstrom S, Marnett LW (eds), Kluwer Academic Press, Boston, MA, 1994.


18. Abdel-Malek Z: How do cafe-au-lait spots arise in neurofibromatosis I? In: Neurofibromatosis, The National Neurofibromatosis Foundation, Inc., Newsletter 15(2), 1994. pp. 2 and 6.


19. Abdel-Malek ZA, Swope VB, Nordlund II: The nature and biological effects of factors responsible for proliferation and differentiation of melanocytes. In: The Pigment Cell: From the Molecular to .th~ Clinical Level. Proceedings of the XlV International Pigment Cell Conference, Kobe, Japan, Y Mishima (ed), Munksgaard, Copenhagen, 1992. pp.43-47.


20. Abdel-Malek ZA: Melanotropin effects on pigment cell proliferation. In: The Melanotropin Peptides, M Hadley (ed), CRC Press, Vol. 2,1988. pp.29-41.


21. Nordlund JJ, Abdel-Malek ZA: Mechanisms for post-inflammatory hyperpigmentation and hypopigmentation. In: Pigment Cell, J Bagnara (ed), Alan R. Liss, Inc., 1988. pp.219-236.


22. Abdel-Malek ZA: Endocrine factors as effectors of integumental pigmentation. In: Dermatologic Clinics 6(2), J Nordlund (ed), W.B. Saunders Co., 1988. pp. 175-183.




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