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•• Path & Lab Med-North
•• Professor
•• Tso Lab •• e-mail:
University of Western Australia, Ph.D., 1978
Research Summary
One of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine. The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology. We are currently studying how bile salts are involved in the absorption of lipids. In addition, we are also studying the factors regulating the synthesis and secretion of apolipoproteins by the small intestine. The apolipoproteins we are studying are: apo AI, apo AIV, apo B, and apo CIII.
1. Liu, M., Doi, T., Shen, L., Woods, S.C., Seeley, R., Zheng, S., Jackman, A., and Tso, P. The intestinal satiety protein apolipoprotein AIV is synthesized and regulated in rat hypothalamus. Am J Physiol 280: R1382-87, 2001.
2. Tso, P., Liu, M., and Kalogeris, T.J. The role of apolipoprotein A-IV in the regulation of food intake. Ann Rev Nutr 21: 231-54, 2001.
3. Nordskog, B. and Tso, P. An examination of the factors affecting intestinal lymphatic transport of dietary lipids. Adv Drug Deliv Rev 50: 21-44, 2001.
4. Tso, P., Lee, T., and DeMichele, J. Randomized structured triglycerides increase lymphatic absorption of tocopherol and retinol compared with the equivalent physical mixture in a rat model of fat malabsorption. J Nutr 131: 2157-63, 2001.
