Sample questions for Med Micro (Immunology)



One best.

1. Which of the following complement products is an anaphylatoxin and has chemotactic properties?
    A. C3 convertase.
    B. The membrane-attack complex.
    C. C1
    D. C5a
    E. Factor D

2. Which of the following is a characteristic of "V-J" joining in kappa light chain genes?
    A. The exact point of joining is imprecise leading to junctional diversity.
    B. The V-J gene recombination occurs after antigen stimulation of the B cells.
    C. The V-J joining occurs by RNA splicing of the primary transcript.
    D. Functional V-J gene rearrangements are found in kidney cells.
    E. All of the above.

3. In which way are natural killer cells (NK cells) similar to cytotoxic T lymphocytes?
    A. Both are known to recognize endogenously processed peptides bound to class I MHC molecules.
    B. Both express the CD3 cell surface marker.
    C. Both mediate cytolytic effector functions using similar mechanisms.
    D. Both have key roles in Type I immediate hypersensitivity reactions.
    E. Both cell types display antigen-specific immunologic memory.

4. Which of the following terms best describes the concept of antigen-specifity in the humoral immune response?
    A. Clonal Selection
    B. Innate immunity
    C. Cytokine induction
    D. MHC-restriction
    E. Self-tolerance

5. Which of the following statements is a property of IgM antibodies?
    A. Pentameric, contains J chain.
    B. First class of antibodies seen in primary response.
    C. High avidity
    D. Found on surface of immature B cells.
    E. All of the above.

6. MHC class I molecules are expressed on unstimulated:
    A. macrophages, B cells and dendritic cells.
    B. T cells.
    C. granulocytes.
    D. NK cells.
    E. all of the above.

7. Graft versus host disease (GVHD) is most likely to occur in which of the following situations?
    A. Liver transplant between HLA non-identical siblings.
    B. Kidney transplant between two non-related individuals who are HLA-matched.
    C. Bone marrow transplant between non-related individuals who are HLA-matched.
    D. Kidney transplant between a parent and sibling.
    E. All of the above.

8. Complement is an important effector mechanism in the pathogenesis of:
    A. Myasthenia gravis.
    B. Goodpasture's syndrome (glomerulonephiritis).
    C. Allergic rhinitis.
    D. Graves' disease (hyperthyroidism).
    E. Contact sensitivity to poison ivy.

9. TAP (Transporter associated with Antigen Processing) molecules are required for:
    A. phagocytosis by macrophages.
    B. normal presentation of antigens to CD4+ T cells.
    C. normal presentation of antigens to CD8+ T cells.
    D. degradation of fireign proteins into peptides.
    E. transport of peptides from the lumen of the endoplasmic reticulum to lysosomes.

10. Signal transduction from the antigen-specific (ab) T cell receptor to the cell interior is mediated by a complex of polypeptides collectively called:
    A. CD1.
    B. CD2.
    C. CD3.
    D. CD4.
    E. CD40.

11. Adenosine deaminase (enzyme) deficiency is associated with:
    A. severe combined immunodeficiency (SCID).
    B. X-linked agammaglobulinemia.
    C. transient hypogammaglobulinemia of infancy.
    D. chronic granulomatous disease.
    E. None of the above.

12. Adhesion molecules such as selectins, integrins or addressins play an important role in:
    A. T lymphocyte recirculation.
    B. induction of inflammation.
    C. homing of lymphocytes to mucosal tissues.
    D. stimulation of T cells by antigen presenting cells.
    E. All of the above.

13. Which of the following is characteristic to TH1 type T cell responses?
    A. Inflammatory responses.
    B. Delayed type hypersinsitivity reactions.
    C. Activation of cytotoxic T lymphocytes and macrophages.
    D. Production of IL-2 and interferon-g.
    E. All of the above.

14. Which of the following cytokines is the most directly involved with inducing immunoglobulin class
switching to IgE?
    A. IL-1
    B. IL-2
    C. IL-4
    D. interferon-g
    E. tumor necrosis factor-a

15. Which of the following determines the idiotype of an immunoglobulin?
    A. The constant region of the heavy chain.
    B. The Fc fragment.
    C. The constant region of the light chain.
    D. The combination of heavy and light chain variable regions.
    E. Allotypic determinants found on the constant region of the heavy chain.

16. All of the following pairs of cell types can be distinguished by cell surface markers using
immunofluorescence EXCEPT:
    A. TH1 and TH2 T cell subsets.
    B. CD4+ and CD8+ T cell subsets.
    C. "Double-positive" and "double-negative" thymocytes.
    D. B and T lymphocytes.
    E. Pre-B cells versus "immature" B cells in the bone marrow.

17. B and T lymphocytes share all the following characteristics EXCEPT:
    A. positive selection
    B. Class I Major Histocompatibility Complex (MHC) expression.
    C. V, D and J genetic recombination.
    D. clonally distributed antigen specific receptors.
    E. dependence on cytokines produced by other cells.

18. Which of the following does NOT apply to MHC class II molecules?
    A. heterodimeric glycoproteins.
    B. expression on B cells.
    C. complement components that participate in the cleavage of C3.
    D. genetically associated with certain autoimmune diseases.
    E. HLA-D.

19. Antibody and complement deposited on encapsulated bacteria enhance phagocytosis by which
characteristic of PMNs?
    A. Respiratory burst
    B. Class II MHC antigens
    C. Fc and C3b receptors
    D. Receptor mediated endocytosis
    E. Pseudopod extensions

Match the following immunologic tests with the descriptions given in questions 20-21.
    A. Immunofluorescence
    B. Complement fixation assay
    C. ELISA (enzyme linked immunosorbent assay)
    D. Direct Coomb's test
    E. Immunoelectrophoresis

20. Used for the diagnosis of Rh disease (hemolytic disease of the newborn).

21. Uses sheep red blood cells (SRBCs) and anti-SRBCs as indicator reagents.


Answers:
1. D. 12. E.
2. A. 13. E.
3. C. 14. C.
4. A. 15. D.
5. E. 16. A.
6. E. 17. A.
7. C. 18. C.
8. B. 19. C.
9. C. 20. D.
10. C. 21. B.
11. A.

I hope I got all the right answers down. Let me know if you think there are any errors/typos/arguments. I can be reached by email at CHOIEM@ucbeh.san.uc.edu or at 2254 (office) of 2153 (lab, around corner from Med Micro labs) . If you have any quick questions on the immunology section of the course please stop by. I can make arrangements for longer appointments also. Hope these sample questions are helpful for your studies. Ed Choi.


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