There are three major areas of research interests in my laboratory. We have developed a "knockout" mouse that will be useful for detecting mutagenic environments using an endogenous gene as a reporter. As a second direction, we are examining signal transduction events mediated by leading the ras oncogene leading to genomic instability. Lastly, we have formed a collaboration with a clinical group to develop novel cancer gene therapy approaches.
Stambrook, P.J., Shao, C., Stockelman, M., Boivin, G., Engle, S.J., Tischfield, J.A. APRT: A versatile in vivo resident reporter of local mutation and loss of heterozygosity. Environ. & Molec. Mutagenesis, 28:471-482, (1996)
Gupta, P.K., Sahota, A., Boyadjiev, S.A., Bye, S., Shao, C., O'Neill, J.P., Hunter, T.C., Albertini, R.J., Stambrook, P.J. and Tischfield, J.A. High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination. Cancer Research, 57:188-193, (1997)
Bi,W., Kim, Y.G., Feliciano, E.S., Pavelic, L., Wilson, K.M., Pavelic, Z.P.Stambrook,P.J. An HSVtk-Mediated Local and Distant Anti-tumor Bystander Effect in Tumors of Head and Neck Origin in Athymic Mice. Cancer Gene Therapy 4:246-252, (1997)
Scrable, H. and Stambrook, P.J. Activation of the lac repressor in the transgenic mouse. Genetics 147:297-304, (1997)