Our laboratory is involved in several research projects that focus on the hypothalamo-pituitary axis at the whole animal, cellular and molecular levels. The major effort is to isolate and sequence a novel peptide, prolactin regulating factor, from the posterior pituitary. A second project is investigating the distribution and regulation of estrogen receptors in the pituitary and the effects of environmental estrogens on the reproductive system. A third project focuses on the role of prolactin and prolactin isoforms in breast cancer, especially as related to angiogenesis.
Ben-Jonathan N, Mershon JL, Allen DL, Steinmetz R. Extrapituitary prolactin: Distribution, regulation, function and clinical aspects. Endocrine Reviews 16:639-669, 1996.
Hnasko R, Khurana S, Shackleford N, Steinmetz R, Low MJ, Ben-Jonathan N. Two distinct pituitary cell lines from mouse intermediate lobe tumors: A cell that produces prolactin regulating factor (PRF) and a melanotroph. Endocrinology 138:5589-5596, 1997.
Ben-Jonathan N, Steinmetz R. Xenoestrogens: The emerging story of bisphenol A. Trends in Endocrinology and Metabolism 9:124-128, 1998.
Mitchner N, Garlick C, Ben-Jonathan N. Cellular distribution and gene regulation of estrogen receptors and in he rat pituitary gland. Endocrinology 139:3976-3983, 1998.
Khurana S, Kuns R, Ben-Jonathan N. Heparin-binding property of human prolactin: A novel aspect of prolactin biology. Endocrinology 140:1026-1029,1999.