Today is Thursday, Dec. 5, 2019

Department of

Cancer Biology - Du Laboratory



Che, Lixiao; Yang, Xingyuan; Ge, Chunmin; El-Amouri, Salim S; Wang, Qi-En; Pan, Dao; Herzog, Thomas J; Du, Chunying 2019. Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis. PloS one, 14 5, e0216553

Ge, Chunmin; Vilfranc, Chrystelle L; Che, Lixiao; Pandita, Raj K; Hambarde, Shashank; Andreassen, Paul R; Niu, Liang; Olowokure, Olugbenga; Shah, Shimul; Waltz, Susan E; Zou, Lee; Wang, Jiang; Pandita, Tej K; Du, Chunying 2019. The BRUCE-ATR signaling axis is required for accurate DNA replication and suppression of liver cancer development. Hepatology (Baltimore, Md.), ,


Lin, Yu-Fen; Shih, Hung-Ying; Shang, Zeng-Fu; Kuo, Ching-Te; Guo, Jiaming; Du, Chunying; Lee, Hsinyu; Chen, Benjamin P C 2018. PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway. Nucleic acids research, ,


Pan, Ji-An; Sun, Yu; Jiang, Ya-Ping; Bott, Alex J; Jaber, Nadia; Dou, Zhixun; Yang, Bin; Chen, Juei-Suei; Catanzaro, Joseph M; Du, Chunying; Ding, Wen-Xing; Diaz-Meco, Maria T; Moscat, Jorge; Ozato, Keiko; Lin, Richard Z; Zong, Wei-Xing 2016. TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Molecular cell, 62 1, 149-151


Garrison, Jason B; Ge, Chunmin; Che, Lixiao; Pullum, Derek A; Peng, Guang; Khan, Sohaib; Ben-Jonathan, Nira; Wang, Jiang; Du, Chunying 2015. Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents. Journal of cancer science & therapy, 7 4, 121-126

Ge, Chunmin; Che, Lixiao; Du, Chunying 2015. The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex. PloS one, 10 12, e0144957

Ge, Chunmin; Che, Lixiao; Ren, Jinyu; Pandita, Raj K; Lu, Jing; Li, Kaiyi; Pandita, Tej K; Du, Chunying 2015. BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proceedings of the National Academy of Sciences of the United States of America, 112 11, E1210-9

Liang, Y; Gao, H; Lin, S-Y; Goss, J A; Du, C; Li, K 2015. Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model. Oncogene, 34 33, 4368-78