Today is

Department of

Cancer Biology

Photo of  David Plas, PhD

David Plas, PhD

Associate Professor

Research Interests

The Plas lab aims to discover mechanisms that link cancer-causing mutations to oncogenic metabolism in cancers affected by mutations in PTEN and PI3K, including cancers of the blood, brain, and breast. Current work is investigating the metabolic and apoptotic effects of targeting the protein kinase S6K1, using both genetic approaches and emerging experimental therapeutics.

Education/Credentials
  • BS: University of Notre Dame
  • Ph.D.: Washington University
  • Postdoc: University of Pennsylvania
Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue
  • ML 0521
  • Cincinnati, Ohio 45267
  • Office 513-558-7245
  • Email david.plas [at] uc.edu

Peer Reviewed Publications

Sliz, Anna; Locker, Kathryn C S; Lampe, Kristin; Godarova, Alzbeta; Plas, David R; Janssen, Edith M; Jones, Helen; Herr, Andrew B; Hoebe, Kasper 2019. Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Science immunology, 4 38,

Su, Rui; Dong, Lei; Li, Chenying; Nachtergaele, Sigrid; Wunderlich, Mark; Qing, Ying; Deng, Xiaolan; Wang, Yungui; Weng, Xiaocheng; Hu, Chao; Yu, Mengxia; Skibbe, Jennifer; Dai, Qing; Zou, Dongling; Wu, Tong; Yu, Kangkang; Weng, Hengyou; Huang, Huilin; Ferchen, Kyle; Qin, Xi; Zhang, Bin; Qi, Jun; Sasaki, Atsuo T; Plas, David R; Bradner, James E; Wei, Minjie; Marcucci, Guido; Jiang, Xi; Mulloy, James C; Jin, Jie; He, Chuan; Chen, Jianjun 2018. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell, 172 1-2, 90-105.e23

Berman, Adi Y; Manna, Subrata; Schwartz, Naomi S; Katz, Yardena E; Sun, Yang; Behrmann, Catherine A; Yu, Jane J; Plas, David R; Alayev, Anya; Holz, Marina K 2017. ERRα regulates the growth of triple-negative breast cancer cells via S6K1-dependent mechanism. Signal transduction and targeted therapy, 2 ,

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kohei; Li, Na; Kopras, Elizabeth J; Kwiatkowski, David J; Borchers, Michael T; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Mays, Maxwell; Sun, Yang; Plas, David R; Sun, Julia L; Franz, David N; Capal, Jamie K; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells. Molecular cancer research : MCR, ,

Liu, Hongqi; Feng, Xizhi; Ennis, Kelli N; Behrmann, Catherine A; Sarma, Pranjal; Jiang, Tony T; Kofuji, Satoshi; Niu, Liang; Stratton, Yiwen; Thomas, Hala Elnakat; Yoon, Sang-Oh; Sasaki, Atsuo T; Plas, David R 2017. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell reports, 18 9, 2088-2095

Orr-Asman, Melissa A; Chu, Zhengtao; Jiang, Min; Worley, Mariah; LaSance, Kathleen; Koch, Sheryl E; Carreira, Vinicius S; Dahche, Hanan M; Plas, David R; Komurov, Kakajan; Qi, Xiaoyang; Mercer, Carol A; Anthony, Lowell B; Rubinstein, Jack; Thomas, Hala E 2017. mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment. Molecular cancer therapeutics, 16 11, 2432-2441

Yoon, Sang-Oh; Shin, Sejeong; Karreth, Florian A; Buel, Gwen R; Jedrychowski, Mark P; Plas, David R; Dedhar, Shoukat; Gygi, Steven P; Roux, Philippe P; Dephoure, Noah; Blenis, John 2017. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular cell, ,

Ghosh, Joydeep; Kobayashi, Michihiro; Ramdas, Baskar; Chatterjee, Anindya; Ma, Peilin; Mali, Raghuveer Singh; Carlesso, Nadia; Liu, Yan; Plas, David R; Chan, Rebecca J; Kapur, Reuben 2016. S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance. The Journal of clinical investigation, 126 7, 2621-5

Shin, Sejeong; Buel, Gwen R; Wolgamott, Laura; Plas, David R; Asara, John M; Blenis, John; Yoon, Sang-Oh 2015. ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Molecular cell, 59 3, 382-98

Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar 2015. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature communications, 6 , 8428

Hall, Daniel P; Cost, Nicholas G; Hegde, Shailaja; Kellner, Emily; Mikhaylova, Olga; Stratton, Yiwen; Ehmer, Birgit; Abplanalp, William A; Pandey, Raghav; Biesiada, Jacek; Harteneck, Christian; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F 2014. TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma. Cancer cell, 26 5, 738-53

Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y 2014. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma. International journal of cancer. Journal international du cancer, 134 1, 9-20

Barger, JF; Gallo, CA; Tandon, P; Liu, H; Sullivan, A; Grimes, HL; Plas, DR 2013. S6K1 determines the metabolic requirements for BCR-ABL survival Oncogene, 32 4, 453-61

Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F; Castilla, Elias A; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M; Plas, David R; Riedl, Stefan J; Leitges, Michael; Diaz-Meco, Maria T; Richardson, Adam D; Moscat, Jorge 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611

Raynor, Jana; Sholl, Allyson; Plas, David R; Bouillet, Philippe; Chougnet, Claire A; Hildeman, David A 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Frontiers in immunology, 4 , 161

Aksoylar H, Lampe K, Barnes M, Plas DR, Hoebe K 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo transcription factor expression in CD4+ lymphocytes Journal of Immunology, 188 1, 146

Aksoylar, H Ibrahim; Lampe, Kristin; Barnes, Michael J; Plas, David R; Hoebe, Kasper 2012. Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950), 188 1, 146-54

Czyzyk-Krzeska, Maria F; Meller, Jarek; Plas, David R 2012. Not all autophagy is equal. Autophagy, 8 7, 1155-6

Mikhaylova, Olga; Stratton, Yiwen; Hall, Daniel; Kellner, Emily; Ehmer, Birgit; Drew, Angela F; Gallo, Catherine A; Plas, David R; Biesiada, Jacek; Meller, Jarek; Czyzyk-Krzeska, Maria F 2012. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer cell, 21 4, 532-46

Barger JF, Gallo CA, Torni KA, Merk L, Seibel WL, Nelson S, Plas DR 2011. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin Cancer Biology & Therapy, 10 12, 1256

Chougnet CA, Tripathi P, Lages CS, Raynor J, Sholl A, Fink P, Plas DR, Hildeman DA 2011. A major role for Bim in regulatory T cell homeostasis Journal of Immunology, 186 1, 156

Chougnet, Claire A; Tripathi, Pulak; Lages, Celine S; Raynor, Jana; Sholl, Allyson; Fink, Pamela; Plas, David R; Hildeman, David A 2011. A major role for Bim in regulatory T cell homeostasis. Journal of immunology (Baltimore, Md. : 1950), 186 1, 156-63

Coloff JL, MacIntyre AN, Nichols AN, Liu T, Gallo CA, Plas DR, Rathmell JC 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition Cancer Research, 71 15, 5204

Coloff, Jonathan L; Macintyre, Andrew N; Nichols, Amanda G; Liu, Tingyu; Gallo, Catherine A; Plas, David R; Rathmell, Jeffrey C 2011. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer research, 71 15, 5204-13

Giridhar PV, Funk HM, Gallo CA, Porollo A, Mercer CA, Plas DR, Drew AF 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells Clinical and Experimental Metastasis, 28 8, 887

Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97

Sommermann T, O’Neill , Plas DR, and Cahir-McFarland E 2011. IKKβ and NFκB transcription govern AKT-induced GLUT1 plasma membrane trafficking in B-lymphocytes Cancer Research, 71 23, 7291

Sommermann, Thomas G; O'Neill, Kathleen; Plas, David R; Cahir-McFarland, Ellen 2011. IKK? and NF-?B transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. Cancer research, 71 23, 7291-300

Tandon P, Gallo CA, Khatri S, Barger, JF, Yepiskoposyan H, Plas DR 2011. Requirement for S6K1 to mediate glycolysis and apoptosis resistance induced by Pten-deficiency Proceedings of the National Academy of Sciences (USA), 108 6, 2361

Tandon, Preeti; Gallo, Catherine A; Khatri, Shikha; Barger, Jennifer F; Yepiskoposyan, Hasmik; Plas, David R 2011. Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency. Proceedings of the National Academy of Sciences of the United States of America, 108 6, 2361-5

Zhang Y, Johansson E, Miller ML, Jänicke RU, Ferguson DJ, Plas D, Meller J, Anderson MW 2011. Identification of a Conserved Anti-apoptotic Protein that Modulates the Mitochondrial Apoptosis Pathway Plos One, 6 9, e25284

Barger JF, Plas DR 2010. Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis Endocrine-related cancer, ,

Barger, Jennifer F; Gallo, Catherine A; Torni, Kyle A; Merk, Lisa; Seibel, William L; Nelson, Sandra; Plas, David R 2010. Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to rapamycin. Cancer biology & therapy, 10 12, 1256-61

Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR 2010. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1 The Journal of biological chemistry, 285 21, 15960-5

Khatri S, Plas DR 2009. Targeting bioenergetics to enhance cancer chemotherapy: mitochondria SLP into apoptosis Cancer biology & therapy, 8 17, 1659-61

Plas DR, Thomas G 2009. Tubers and tumors: rapamycin therapy for benign and malignant tumors Current opinion in cell biology, 21 2, 230-6

Jones, Russell G; Plas, David R; Kubek, Sara; Buzzai, Monica; Mu, James; Xu, Yang; Birnbaum, Morris J; Thompson, Craig B 2005. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular cell, 18 3, 283-93

Plas, David R; Thompson, Craig B 2005. Akt-dependent transformation: there is more to growth than just surviving. Oncogene, 24 50, 7435-42

Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2004. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer research, 64 10, 3500-7

Bauer, Daniel E; Harris, Marian H; Plas, David R; Lum, Julian J; Hammerman, Peter S; Rathmell, Jeffrey C; Riley, James L; Thompson, Craig B 2004. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18 11, 1303-5

Elstrom, Rebecca L; Bauer, Daniel E; Buzzai, Monica; Karnauskas, Robyn; Harris, Marian H; Plas, David R; Zhuang, Hongming; Cinalli, Ryan M; Alavi, Abass; Rudin, Charles M; Thompson, Craig B 2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer research, 64 11, 3892-9

Karnauskas, Robyn; Niu, Qun; Talapatra, Sunit; Plas, David R; Greene, Marianne E; Crispino, John D; Rudin, Charles M 2003. Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene, 22 5, 688-98

Plas, David R; Thompson, Craig B 2003. Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. The Journal of biological chemistry, 278 14, 12361-6

Rathmell, Jeffrey C; Fox, Casey J; Plas, David R; Hammerman, Peter S; Cinalli, Ryan M; Thompson, Craig B 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and cellular biology, 23 20, 7315-28

Arsham, Andrew M; Plas, David R; Thompson, Craig B; Simon, M Celeste 2002. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. The Journal of biological chemistry, 277 17, 15162-70

Frauwirth, Kenneth A; Riley, James L; Harris, Marian H; Parry, Richard V; Rathmell, Jeffrey C; Plas, David R; Elstrom, Rebecca L; June, Carl H; Thompson, Craig B 2002. The CD28 signaling pathway regulates glucose metabolism. Immunity, 16 6, 769-77

Plas, David R; Rathmell, Jeffrey C; Thompson, Craig B 2002. Homeostatic control of lymphocyte survival: potential origins and implications. Nature immunology, 3 6, 515-21

Plas, David R; Thompson, Craig B 2002. Cell metabolism in the regulation of programmed cell death. Trends in endocrinology and metabolism: TEM, 13 2, 75-8

Plas, D R; Talapatra, S; Edinger, A L; Rathmell, J C; Thompson, C B 2001. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of biological chemistry, 276 15, 12041-8

Vander Heiden, M G; Plas, D R; Rathmell, J C; Fox, C J; Harris, M H; Thompson, C B 2001. Growth factors can influence cell growth and survival through effects on glucose metabolism. Molecular and cellular biology, 21 17, 5899-912

Dustin, L B; Plas, D R; Wong, J; Hu, Y T; Soto, C; Chan, A C; Thomas, M L 1999. Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. Journal of immunology (Baltimore, Md. : 1950), 162 5, 2717-24

Plas, D R; Williams, C B; Kersh, G J; White, L S; White, J M; Paust, S; Ulyanova, T; Allen, P M; Thomas, M L 1999. Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. Journal of immunology (Baltimore, Md. : 1950), 162 10, 5680-4

Wang, L L; Blasioli, J; Plas, D R; Thomas, M L; Yokoyama, W M 1999. Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B. Journal of immunology (Baltimore, Md. : 1950), 162 3, 1318-23

Plas, D R; Thomas, M L 1998. Negative regulation of antigen receptor signaling in lymphocytes. Journal of molecular medicine (Berlin, Germany), 76 8, 589-95

Matsumoto, M; Lo, S F; Carruthers, C J; Min, J; Mariathasan, S; Huang, G; Plas, D R; Martin, S M; Geha, R S; Nahm, M H; Chaplin, D D 1996. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice. Nature, 382 6590, 462-6

Plas, D R; Johnson, R; Pingel, J T; Matthews, R J; Dalton, M; Roy, G; Chan, A C; Thomas, M L 1996. Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science (New York, N.Y.), 272 5265, 1173-6

Moe, A J; Plas, D R; Powell, K A; Smith, C H . Riboflavin uptake in microvillous and basal membrane vesicles isolated from full-term human placentas. Placenta, 15 2, 137-46