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Department of

Cancer Biology

Photo of  Krushna Patra, PhD

Krushna Patra, PhD

Education/Credentials
  • B.Sc.: Utkal University
  • M.Tech.: Indian Institute of Technology
  • Ph.D: University of Illinois
Contact Information

Peer Reviewed Publications

Goyal, Lipika; Shi, Lei; Liu, Leah Y; Fece de la Cruz, Ferran; Lennerz, Jochen K; Raghavan, Srivatsan; Leschiner, Ignaty; Elagina, Liudmila; Siravegna, Giulia; Ng, Raymond W S; Vu, Phuong; Patra, Krushna C; Saha, Supriya K; Uppot, Raul N; Arellano, Ron; Reyes, Stephanie; Sagara, Takeshi; Otsuki, Sachie; Nadres, Brandon; Shahzade, Heather A; Dey-Guha, Ipsita; Fetter, Isobel J; Baiev, Islam; Van Seventer, Emily E; Murphy, Janet E; Ferrone, Cristina R; Tanabe, Kenneth K; Deshpande, Vikram; Harding, James J; Yaeger, Rona; Kelley, Robin K; Bardelli, Alberto; Iafrate, A John; Hahn, William C; Benes, Cyril H; Ting, David T; Hirai, Hiroshi; Getz, Gad; Juric, Dejan; Zhu, Andrew X; Corcoran, Ryan B; Bardeesy, Nabeel 2019. TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma. Cancer discovery, 9 8, 1064-1079

Patra, Krushna C; Weerasekara, Vajira K; Bardeesy, Nabeel 2019. AMPK-Mediated Lysosome Biogenesis in Lung Cancer Growth. Cell metabolism, 29 2, 238-240

Weerasekara, Vajira K; Patra, Krushna C; Bardeesy, Nabeel 2019. EGFR Pathway Links Amino Acid Levels and Induction of Macropinocytosis. Developmental cell, 50 3, 261-263

DeWaal, Dannielle; Nogueira, Veronique; Terry, Alexander R; Patra, Krushna C; Jeon, Sang-Min; Guzman, Grace; Au, Jennifer; Long, Christopher P; Antoniewicz, Maciek R; Hay, Nissim 2018. Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nature communications, 9 1, 446

Hill, Margaret A; Alexander, William B; Guo, Bing; Kato, Yasutaka; Patra, Krushna; O'Dell, Michael R; McCall, Matthew N; Whitney-Miller, Christa L; Bardeesy, Nabeel; Hezel, Aram F 2018. Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma. Cancer research, 78 16, 4445-4451

Nogueira, Veronique; Patra, Krushna C; Hay, Nissim 2018. Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation. eLife, 7 ,

Patra, Krushna C; Bardeesy, Nabeel 2018. A Cell Size Theory of Aging. Developmental cell, 45 6, 665-666

Patra, Krushna C; Kato, Yasutaka; Mizukami, Yusuke; Widholz, Sebastian; Boukhali, Myriam; Revenco, Iulia; Grossman, Elizabeth A; Ji, Fei; Sadreyev, Ruslan I; Liss, Andrew S; Screaton, Robert A; Sakamoto, Kei; Ryan, David P; Mino-Kenudson, Mari; Castillo, Carlos Fernandez-Del; Nomura, Daniel K; Haas, Wilhelm; Bardeesy, Nabeel 2018. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nature cell biology, 20 7, 811-822

Patra, Krushna C; Bardeesy, Nabeel; Mizukami, Yusuke 2017. Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm. Clinical and translational gastroenterology, 8 4, e86

Yu, Wan-Ni; Nogueira, Veronique; Sobhakumari, Arya; Patra, Krushna C; Bhaskar, Prashanth T; Hay, Nissim 2015. Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. Cell reports, 12 4, 610-21

Patra, Krushna C; Hay, Nissim 2014. The pentose phosphate pathway and cancer. Trends in biochemical sciences, 39 8, 347-54

Patra, Krushna C; Hay, Nissim 2013. Hexokinase 2 as oncotarget. Oncotarget, 4 11, 1862-3

Patra, Krushna C; Wang, Qi; Bhaskar, Prashanth T; Miller, Luke; Wang, Zebin; Wheaton, Will; Chandel, Navdeep; Laakso, Markku; Muller, William J; Allen, Eric L; Jha, Abhishek K; Smolen, Gromoslaw A; Clasquin, Michelle F; Robey, Brooks; Hay, Nissim 2013. Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer cell, 24 2, 213-228

Roy, Nilotpal; Bommi, Prashant V; Bhat, Uppoor G; Bhattacharjee, Shaumick; Elangovan, Indira; Li, Jing; Patra, Krushna C; Kopanja, Dragana; Blunier, Adam; Benya, Richard; Bagchi, Srilata; Raychaudhuri, Pradip 2013. DDB2 suppresses epithelial-to-mesenchymal transition in colon cancer. Cancer research, 73 12, 3771-82

Bhaskar, Prashanth T; Nogueira, Veronique; Patra, Krushna C; Jeon, Sang-Min; Park, Youngkyu; Robey, R Brooks; Hay, Nissim 2009. mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Molecular and cellular biology, 29 18, 5136-47

Banerjee, Rintu; Mukherjee, Gargi; Patra, Krushna Chandra 2005. Microbial transformation of tannin-rich substrate to gallic acid through co-culture method. Bioresource technology, 96 8, 949-53