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Department of

Cancer Biology

Photo of Yanbo Fan, Ph.D.

Yanbo Fan, Ph.D.

Research Interests

The long-term goal of Dr. Fan’s research is to explore the mechanisms of vascular diseases and the intersection of vascular diseases and cancer. The Fan laboratory is interested in the molecular mechanisms mediating cell metabolism, apoptosis, and inflammation in vascular diseases and tumor vascular biology. Dr. Fan aims to identify novel promising therapeutic targets for these diseases by human genetics, molecular cell, and animal studies. As one of the major research directions, Dr. Fan’s laboratory focuses on is defining the role of transcription factor EB (TFEB), a master regulator for autophagy and lysosome biogenesis, in vascular endothelial cells and smooth muscle cells important for angiogenesis, cancer metastasis, aneurysm, and other vascular and metabolic diseases.

Education/Credentials
  • Bachelor: Hebei Medical University
  • PhD: Peking University
Contact Information

Peer Reviewed Publications

Liang, Wenying*; Fan, Yanbo*,#; Lu, Haocheng; Chang, Ziyi; Hu, Wenting; Sun, Jinjian; Wang, Huilun; Zhu, Tianqing; Wang, Jintao; Adili, Reheman; Garcia-Barrio, Minerva T; Holinstat, Michael; Eitzman, Daniel; Zhang, Jifeng; Chen, Y Eugene 2019. KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall. Arteriosclerosis, thrombosis, and vascular biology, 39 3, 402-412

Lu, Haocheng; Sun, Jinjian; Liang, Wenying; Zhang, Jifeng; Rom, Oren; Garcia-Barrio, Minerva T; Li, Shengdi; Villacorta, Luis; Schopfer, Francisco J; Freeman, Bruce A; Chen, Y Eugene; Fan, Yanbo 2019. Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells. Physiological genomics, 51 6, 224-233

Rom, Oren; Xu, Guan; Guo, Yanhong; Zhu, Yunhao; Wang, Huilun; Zhang, Jifeng; Fan, Yanbo; Liang, Wenying; Lu, Haocheng; Liu, Yuhao; Aviram, Michael; Liu, Zhipeng; Kim, Seongho; Liu, Wanqing; Wang, Xueding; Chen, Y Eugene; Villacorta, Luis 2019. Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice. EBioMedicine, 41 , 62-72

Chang, Lin; Xiong, Wenhao; Zhao, Xiangjie; Fan, Yanbo; Guo, Yanhong; Garcia-Barrio, Minerva; Zhang, Jifeng; Jiang, Zhisheng; Lin, Jiandie D; Chen, Y Eugene 2018. Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen. Circulation, 138 1, 67-79

Fan, Yanbo#; Lu, Haocheng; Liang, Wenying; Garcia-Barrio, Minerva T; Guo, Yanhong; Zhang, Ji; Zhu, Tianqing; Hao, Yibai; Zhang, Jifeng; Chen, Y Eugene 2018. Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis. Circulation research, 122 7, 945-957

Hu, Wenting; Lu, Haocheng; Zhang, Jifeng; Fan, Yanbo; Chang, Ziyi; Liang, Wenying; Wang, Huilun; Zhu, Tianqing; Garcia-Barrio, Minerva T; Peng, Daoquan; Chen, Y Eugene; Guo, Yanhong 2018. Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-?B signaling pathway. Atherosclerosis, 278 , 39-48

Qiao, Congzhen; Li, Shengdi; Lu, Haocheng; Meng, Fan; Fan, Yanbo; Guo, Yanhong; Chen, Y Eugene; Zhang, Jifeng 2018. Laminar Flow Attenuates Macrophage Migration Inhibitory Factor Expression in Endothelial Cells. Scientific reports, 8 1, 2360

Xiong, Wenhao; Zhao, Xiangjie; Villacorta, Luis; Rom, Oren; Garcia-Barrio, Minerva T; Guo, Yanhong; Fan, Yanbo; Zhu, Tianqing; Zhang, Jifeng; Zeng, Rong; Chen, Y Eugene; Jiang, Zhisheng; Chang, Lin 2018. Brown Adipocyte-Specific PPAR? (Peroxisome Proliferator-Activated Receptor ?) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice. Arteriosclerosis, thrombosis, and vascular biology, 38 8, 1738-1747

Fan, Yanbo#; Lu, Haocheng; Liang, Wenying; Hu, Wenting; Zhang, Jifeng; Chen, Y Eugene 2017. Krüppel-like factors and vascular wall homeostasis. Journal of molecular cell biology, 9 5, 352-363

Lu, Haocheng*; Fan, Yanbo*,#; Qiao, Congzhen; Liang, Wenying; Hu, Wenting; Zhu, Tianqing; Zhang, Jifeng; Chen, Y Eugene 2017. TFEB inhibits endothelial cell inflammation and reduces atherosclerosis. Science signaling, 10 464,

Zhang, Jifeng; Niimi, Manabu; Yang, Dongshan; Liang, Jingyan; Xu, Jie; Kimura, Tokuhide; Mathew, Anna V; Guo, Yanhong; Fan, Yanbo; Zhu, Tianqing; Song, Jun; Ackermann, Rose; Koike, Yui; Schwendeman, Anna; Lai, Liangxue; Pennathur, Subramaniam; Garcia-Barrio, Minerva; Fan, Jianglin; Chen, Y Eugene 2017. Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits. Arteriosclerosis, thrombosis, and vascular biology, 37 6, 1068-1075

Fan, Yanbo; Lu, Haocheng; Guo, Yanhong; Zhu, Tianqing; Garcia-Barrio, Minerva T; Jiang, Zhisheng; Willer, Cristen J; Zhang, Jifeng; Chen, Y Eugene 2016. Hepatic Transmembrane 6 Superfamily Member 2 Regulates Cholesterol Metabolism in Mice. Gastroenterology, 150 5, 1208-1218

Zhang, Ji; Qiao, Congzhen; Chang, Lin; Guo, Yanhong; Fan, Yanbo; Villacorta, Luis; Chen, Y Eugene; Zhang, Jifeng 2016. Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy. PloS one, 11 6, e0157372

Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng; Lomberk, Gwen A; Zhou, Zhou; Sun, Lijie; Mathison, Angela J; Garcia-Barrio, Minerva T; Zhang, Ji; Zeng, Lixia; Li, Lei; Pennathur, Subramaniam; Willer, Cristen J; Rader, Daniel J; Urrutia, Raul; Chen, Y Eugene 2015. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. The Journal of clinical investigation, 125 10, 3819-30

Yin, Ke-Jie; Hamblin, Milton; Fan, Yanbo; Zhang, Jifeng; Chen, Y Eugene 2015. Krüpple-like factors in the central nervous system: novel mediators in stroke. Metabolic brain disease, 30 2, 401-10

Holmen, Oddgeir L*; Zhang, He*; Fan, Yanbo*; Hovelson, Daniel H; Schmidt, Ellen M; Zhou, Wei; Guo, Yanhong; Zhang, Ji; Langhammer, Arnulf; Løchen, Maja-Lisa; Ganesh, Santhi K; Vatten, Lars; Skorpen, Frank; Dalen, Håvard; Zhang, Jifeng; Pennathur, Subramaniam; Chen, Jin; Platou, Carl; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Boehnke, Michael; Chen, Y Eugene; Abecasis, Gonçalo R; Hveem, Kristian; Willer, Cristen J 2014. Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature genetics, 46 4, 345-51

Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng; Chang, Lin; Lin, Jiandie D; Chen, Y Eugene 2013. Peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells. The Journal of biological chemistry, 288 7, 4625-36

Liu, Ling; Zhou, Zhou; Huang, Shengping; Guo, Yanhong; Fan, Yanbo; Zhang, Ji; Zhang, Jifeng; Fu, Mingui; Chen, Y Eugene 2013. Zc3h12c inhibits vascular inflammation by repressing NF-?B activation and pro-inflammatory gene expression in endothelial cells. The Biochemical journal, 451 1, 55-60

Yang, Dongshan; Zhang, Jifeng; Xu, Jie; Zhu, Tianqing; Fan, Yanbo; Fan, Jianglin; Chen, Y Eugene 2013. Production of apolipoprotein C-III knockout rabbits using zinc finger nucleases. Journal of visualized experiments : JoVE, 81, e50957

Yin, Ke-Jie*; Fan, Yanbo*; Hamblin, Milton; Zhang, Jifeng; Zhu, Tainqing; Li, Siming; Hawse, John R; Subramaniam, Malayannan; Song, Chao-Zhong; Urrutia, Raul; Lin, Jiandie D; Chen, Y Eugene 2013. KLF11 mediates PPAR? cerebrovascular protection in ischaemic stroke. Brain : a journal of neurology, 136 Pt 4, 1274-87

Fan, Yanbo; Guo, Yanhong; Zhang, Jifeng; Subramaniam, Malayannan; Song, Chao-Zhong; Urrutia, Raul; Chen, Y Eugene 2012. Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-?B signaling pathway. Arteriosclerosis, thrombosis, and vascular biology, 32 12, 2981-8

Fan, Yanbo; Chen, Y Eugene 2011. Combined therapeutic strategy to improve vascular endothelial function after implantation of sirolimus-eluting stents. Circulation journal : official journal of the Japanese Circulation Society, 75 5, 1051-2

Fan, Yanbo; Guo, Yanhong; Hamblin, Milton; Chang, Lin; Zhang, Jifeng; Chen, Y Eugene 2011. Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor ?. The Journal of biological chemistry, 286 47, 40584-94

Hamblin, Milton; Chang, Lin; Fan, Yanbo; Zhang, Jifeng; Chen, Y Eugene 2009. PPARs and the cardiovascular system. Antioxidants & redox signaling, 11 6, 1415-52

Zhang, Peng; Wang, Ying; Fan, Yanbo; Tang, Zhihui; Wang, Nanping 2009. Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 29 1, 67-74

Fan, Yanbo; Wang, Ying; Tang, Zhihui; Zhang, Hong; Qin, Xiaomei; Zhu, Yi; Guan, Youfei; Wang, Xian; Staels, Bart; Chien, Shu; Wang, Nanping 2008. Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 28 2, 315-21

Qin, Xiaomei; Xie, Xuefen; Fan, Yanbo; Tian, Jianwei; Guan, Youfei; Wang, Xian; Zhu, Yi; Wang, Nanping 2008. Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. Hepatology (Baltimore, Md.), 48 2, 432-41

Tang, Zhihui; Wang, Ying; Fan, Yanbo; Zhu, Yi; Chien, Shu; Wang, Nanping 2008. Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries. Circulation, 118 7, 764-72

Zhang, Hong; Li, Yuanyuan; Fan, Yanbo; Wu, Jing; Zhao, Beilei; Guan, Youfei; Chien, Shu; Wang, Nanping 2008. Klotho is a target gene of PPAR-gamma. Kidney international, 74 6, 732-9

Zhou, Yunfeng; Zhang, Xiaoyan; Chen, Lihong; Wu, Jing; Dang, Huaixin; Wei, Mingfen; Fan, Yanbo; Zhang, Yahua; Zhu, Yi; Wang, Nanping; Breyer, Matthew D; Guan, Youfei 2008. Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. American journal of physiology. Renal physiology, 295 3, F662-71

Qin, Xiaomei; Tian, Jianwei; Zhang, Peng; Fan, Yanbo; Chen, Li; Guan, Youfei; Fu, Yi; Zhu, Yi; Chien, Shu; Wang, Nanping 2007. Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovascular research, 74 3, 506-14