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Department of

Cancer Biology

Photo of  Chunying Du, PhD

Chunying Du, PhD

Associate Professor

Research Interests

Our research is directed at understanding the molecular mechanisms of apoptosis, autophagy, DNA damage response, and genome stability. We are using genetic, molecular and biochemical analyses in the mouse and cell culture systems to address important questions such as how dysregulation of these processes are implicated in cancer and other diseases.

Education/Credentials
  • Doctoral Degree: Iowa State University-Molecular, Cellular & Developmental Biology Program
  • Post Doctoral Fellowship: University of Texas-Southwestern Medical Center in Dallas
Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue
  • ML 0521
  • Cincinnati, Ohio 45267
  • Office 513-558-4803
  • Email chunying.du@uc.edu
  • UC Institute Member Seal

Peer Reviewed Publications

Che, Lixiao; Yang, Xingyuan; Ge, Chunmin; El-Amouri, Salim S; Wang, Qi-En; Pan, Dao; Herzog, Thomas J; Du, Chunying 2019. Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis. PloS one, 14 5, e0216553

Ge, Chunmin; Vilfranc, Chrystelle L; Che, Lixiao; Pandita, Raj K; Hambarde, Shashank; Andreassen, Paul R; Niu, Liang; Olowokure, Olugbenga; Shah, Shimul; Waltz, Susan E; Zou, Lee; Wang, Jiang; Pandita, Tej K; Du, Chunying 2019. The BRUCE-ATR signaling axis is required for accurate DNA replication and suppression of liver cancer development. Hepatology (Baltimore, Md.), ,

Lin, Yu-Fen; Shih, Hung-Ying; Shang, Zeng-Fu; Kuo, Ching-Te; Guo, Jiaming; Du, Chunying; Lee, Hsinyu; Chen, Benjamin P C 2018. PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway. Nucleic acids research, ,

Lin, Yu-Fen; Shih, Hung-Ying; Shang, Zeng-Fu; Kuo, Ching-Te; Guo, Jiaming; Du, Chunying; Lee, Hsinyu; Chen, Benjamin P C 2018. PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway. Nucleic acids research, 46 4, 1847-1859

Pan, Ji-An; Sun, Yu; Jiang, Ya-Ping; Bott, Alex J; Jaber, Nadia; Dou, Zhixun; Yang, Bin; Chen, Juei-Suei; Catanzaro, Joseph M; Du, Chunying; Ding, Wen-Xing; Diaz-Meco, Maria T; Moscat, Jorge; Ozato, Keiko; Lin, Richard Z; Zong, Wei-Xing 2016. TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Molecular cell, 62 1, 149-151

Pan, Ji-An; Sun, Yu; Jiang, Ya-Ping; Bott, Alex J; Jaber, Nadia; Dou, Zhixun; Yang, Bin; Chen, Juei-Suei; Catanzaro, Joseph M; Du, Chunying; Ding, Wen-Xing; Diaz-Meco, Maria T; Moscat, Jorge; Ozato, Keiko; Lin, Richard Z; Zong, Wei-Xing 2016. TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Molecular cell, 61 5, 720-33

Garrison, Jason B; Ge, Chunmin; Che, Lixiao; Pullum, Derek A; Peng, Guang; Khan, Sohaib; Ben-Jonathan, Nira; Wang, Jiang; Du, Chunying 2015. Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents. Journal of cancer science & therapy, 7 4, 121-126

Ge, Chunmin; Che, Lixiao; Du, Chunying 2015. The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex. PloS one, 10 12, e0144957

Ge, Chunmin; Che, Lixiao; Ren, Jinyu; Pandita, Raj K; Lu, Jing; Li, Kaiyi; Pandita, Tej K; Du, Chunying 2015. BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proceedings of the National Academy of Sciences of the United States of America, 112 11, E1210-9

Liang, Y; Gao, H; Lin, S-Y; Goss, J A; Du, C; Li, K 2015. Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model. Oncogene, 34 33, 4368-78

Ren, Keqin; Lu, Jing; Porollo, Aleksey; Du, Chunying 2012. Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. The Journal of biological chemistry, 287 18, 14792-802

Garrison, Jason B; Correa, Ricardo G; Gerlic, Motti; Yip, Kenneth W; Krieg, Andreas; Tamble, Craig M; Shi, Ranxin; Welsh, Kate; Duggineni, Srinivas; Huang, Ziwei; Ren, Keqin; Du, Chunying; Reed, John C 2011. ARTS and Siah collaborate in a pathway for XIAP degradation. Molecular cell, 41 1, 107-16

Jason B. Garrison, Ricardo G. Correa, Motti Gerlic, Kenneth W. Yip, Andreas Krieg, Craig M. Tamble, Ranxin Shi, Kate Welsh, Srinivas Duggineni, Ziwei Huang, Keqin Ren, Chunying Du* and John C. Reed* (*correspondent authors) 2011. ARTS and Siah Collaborate in a Pathway for XIAP Degradation Molecular Cell, 41 , 107 - 116

Bank, Alexander; Wang, Peng; Du, Chunying; Yu, Jian; Zhang, Lin 2008. SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release. Cancer research, 68 1, 276-84

Jones, Natalie C; Lynn, Megan L; Gaudenz, Karin; Sakai, Daisuke; Aoto, Kazushi; Rey, Jean-Phillipe; Glynn, Earl F; Ellington, Lacey; Du, Chunying; Dixon, Jill; Dixon, Michael J; Trainor, Paul A 2008. Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function. Nature medicine, 14 2, 125-33

Ren, Jinyu; Shi, Mingan; Liu, Renshui; Yang, Qi-Heng; Johnson, Teri; Skarnes, William C; Du, Chunying 2005. The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development. Proceedings of the National Academy of Sciences of the United States of America, 102 3, 565-70

Yang, Qi-Heng; Du, Chunying 2004. Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. The Journal of biological chemistry, 279 17, 16963-70

Yang, Qi-Heng; Church-Hajduk, Robin; Ren, Jinyu; Newton, Michelle L; Du, Chunying 2003. Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes & development, 17 12, 1487-96

Carson, Jonathan P; Behnam, Marcelina; Sutton, Jennifer N; Du, Chunying; Wang, Xiaodong; Hunt, Donald F; Weber, Michael J; Kulik, George 2002. Smac is required for cytochrome c-induced apoptosis in prostate cancer LNCaP cells. Cancer research, 62 1, 18-23

Deshmukh, Mohanish; Du, Chunying; Wang, Xiaodong; Johnson, Eugene M 2002. Exogenous smac induces competence and permits caspase activation in sympathetic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 18, 8018-27

Li, Shuchen; Zhao, Yongge; He, Xi; Kim, Tae-Hyoung; Kuharsky, Diane K; Rabinowich, Hannah; Chen, Jun; Du, Chunying; Yin, Xiao-Ming 2002. Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. The Journal of biological chemistry, 277 30, 26912-20

Okada, Hitoshi; Suh, Woong-Kyung; Jin, Jianping; Woo, Minna; Du, Chunying; Elia, Andrew; Duncan, Gordon S; Wakeham, Andrew; Itie, Annick; Lowe, Scott W; Wang, Xiaodong; Mak, Tak W 2002. Generation and characterization of Smac/DIABLO-deficient mice. Molecular and cellular biology, 22 10, 3509-17