Research, UC Center for Transport and Membranes

Research

The MURI grant was awarded to the proposal generated in response to the 2002 MURI call for proposals, topic 4, "Flexible Membranes Exploiting Selective Active Transport."
Text of Original Call For Proposals, MURI topic 4

Objective

To produce synthetic flexible membranes containing biological transport proteins that can utilize energy for the selective uptake, concentration, and release of ions and molecules in an organized manner. The effort includes production of both macroscopic membranes and nanostructures containing transport proteins with vectorial transport function.

Approach

Reconstitution: To reconstitute membrane proteins into synthetic flexible membranes in functional form
More on Reconstitution
Structure/Function: To investigate the structural determinants of regulatory regions in native and specifically modified or engineered proteins
More on Structure/Function
New Transport Properties: To identify and engineer, using guidance from computational modeling, transport systems with the capability to transport other substances
More on New Transport Properties

Summary Overview on membranes, transport dynamics, and project goals (Overview Presentation)