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Medical Scientist Training Program

Program Faculty

Faculty By the Numbers

121 Faculty Members 12 Currently hold NIH Training Grants
27 Physician Scientists 34 Female Faculty Members
By Program
6 Biomedical Engineering 6 Molecular Genetics, Biochemistry, & Microbiology
3 Biomedical Informatics 3 Molecular, Cellular & Biochemical Pharmacology
7 Cancer & Cell Biology 7 Neuroscience
6 Environmental Health 12 Pathobiology & Molecular Medicine
22 Immunology 4 Systems Biology & Physiology
37 Molecular & Developmental Biology


Faculty Search

Looking for faculty who share your research interests? Check out our new Research Directory.

MSTP Faculty

Name Research Bio Contact
Alenghat, Theresa Epithelial and immune cell homeostasis in the context of intestinal health and disease. The goals of the lab are to provide insight into molecular mechanisms, including epigenomic pathways, that mediate the host-microbiota relationship. Theresa.Alenghat@cchmc.org

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Askew, David Understand the contribution of endoplasmic reticulum stress responses to the virulence and antifungal drug susceptibility of the pathogenic mold Aspergillus fumigatus. askewds@ucmail.uc.edu

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Bezerra, Jorge Investigation of the developmental basis of pediatric liver disease, with a focus genetic, cellular and molecular circuitsthat control injury and survival signals. jorge.bezerra@cchmc.org

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Blaxall, Blaxall Molecular and signaling mechanisms of heart failure; cardiac fibrosis; drug and therapeutic discovery. burns.blaxall@cchmc.org

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Bogdanov, Vladimir Biochemistry of Blood Coagulation, Expression and Alternative Splicing of Tissue Factor (TF) pre-mRNA in the Vasculature, Circulating TF in Health and Disease, TF and the Pathobiology of Cancer, Alternatively Spliced TF and Angiogenesis. bogdanvr@ucmail.uc.edu

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Boissy, Raymond Molecular biology of the melanocyte; pathophysiology of pigment disorders. boissyre@ucmail.uc.edu

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Boyce, Steven Mechanisms of skin repair and regeneration with engineered skin substitutes made from cultured cells and biopolymers; treatment of burns and congenital lesions; control of scar steven.boyce@uc.edu

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Bridges, James

Research efforts in the Bridges lab focus on the molecular regulation of alveolar epithelial cell maturation and function in the developing and diseased lung.

james.bridges@cchmc.org

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Brugmann, Samantha Interested in craniofacial development and the etiology of craniofacial disorders samantha.brugmann@cchmc.org

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Campbell, Kenneth Our research focuses on the molecular genetics of neural development with a focus on development of the basal ganglia and surrounding ventral telencephalic regions. kenneth.campbell@cchmc.org

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Cancelas Perez, Jose Cellular and molecular mechanisms of normal and cancer hematopoietic stem cells, and transfusion medicine jose.cancelas@uc.edu

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Cecil, Kim MR spectroscopy and imaging; evaluating the effects of environmental neurotoxicants and radiation, creatinedeficiency syndromes kim.cecil@cchmc.org

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Chen, Jianjun

The Chen laboratory aims to decipher the genetic and epigenetic (e.g., DNA/RNA modification) mechanisms underlying tumorigenesis, and to develop effective novel therapeutics to treat cancers.

chen3jj@uc.edu

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Chougnet, Claire HIV/AIDS pathogenesis; ontogeny of the immune system; immune dysfunction in aging; human immunology
claire.chougnet@cchmc.org

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Clark, Joseph Concussion and mTBI diagnosis, management, return to play, rehabilitation and recovery.

clarkjf@ucmail.uc.edu

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Cleveland, Zackary

Our research focusses on developing radiation-fee methods to quantify regional lung structure and function in patients and small animal models of disease. Specifically, we apply ultra-short echo time and hyperpolarized gas MRI to a variety of disorders, including environmental exposure, interstitial lung disease, cystic fibrosis, and acute lung injury.

Zackary.Cleveland@cchmc.org

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Cushion, Melanie Metatranscriptomics and preclinical drug development for treatment of the AIDS-related opportunistic pathogen Pneumocystis carinii. cushiomt@ucmail.uc.edu

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Czyzyk-Krzeska, Maria Molecular pathways regulated by renal cancer tumor suppressor, particularly VHL. Mechanisms of oncogenic and tumorsuppressing autophagy. MicroRNA networks in control of autophagy. czyzkm@ucmail.uc.edu

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Dauber, Andrew Our lab is interested in studying patients with severe growth disorders in order to understand the molecular basis of growth and its perturbations. Andrew.Dauber@cchmc.org

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Davidson, Sean The overall aim of the lab is to understand the mechanisms by which the body protects itself from heart disease. We use mutagenesis and spectroscopic techniques to study the structure/function relationships of the proteins that comprise high density lipoproteins.
davidswm@ucmail.uc.edu

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Deepe, George We examine the host response to fungal pathogens, in particular Histoplasma capsulatum. Our principal goals are tounderstand the immune regulators of resistance and susceptiblity. deepegs@ucmail.uc.edu

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Deka, Ranjan Epidemiology and genetics of complex diseases, particularly identifying susceptibility genes predisposing individuals to cardiometabolic diseases and type 2 diabetes. dekar@ucmail.uc.edu

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DelBello, Melissa Neurodevelopment of childhood and adolescent bipolar and the neuropsychopharmacology of bipolar disorder inchildren and adolescents.

melissa.delbello@uc.edu

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DeMazumder, Deeptankar

Physician-scientist in cardiac electrophysiology (EP) focusing on the mechanistic link between heart failure and sudden cardiac death in the context of patho/physiological mechanisms, novel therapies, clinically-relevant animal models, “big data” predictive analytics and epidemiology.

deeptankar.demazumder@uc.edu

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Dey, Sudhansu Molecular and genetic basis of embryo implantation. sk.dey@cchmc.org

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Divanovic, Senad Innate immune responses; obesity; NAFLD; preterm birth senad.divanovic@cchmc.org

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Erickson, Craig Fragile X syndrome; autism spectrum disorders Craig.Erickson@cchmc.org

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Gebelein, Brian Patterning the nervous system during development brian.gebelein@cchmc.org

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Grimes, H. Leighton Transcriptional and epigenetic circuits underlying both normal and malignant hematopoiesis lee.grimes@cchmc.org

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Gross, Nina Analysis of molecular mechanisms underlying brain disorders such as Fragile X syndrome, epilepsy and autism with the goal to identify novel treatment targets Christina.Gross@cchmc.org

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Hamada, Fumika Thermo- and pain sensation in Drosophila. Fumika.Hamada@cchmc.org

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Harley, John Lupus genetics, genetics, and genomics john.harley@cchmc.org

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Hassett, Daniel We work on CF lung disease. We patented a novel treatment that has been through animal toxicology and human phase I trials, acidified nitrite.

daniel.hassett@uc.edu

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Haynes, Erin Effect of low-level toxicant exposures on neurobehavioral outcomes erin.haynes@uc.edu

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Herman, James structural, functional and molecular biological principles underlying brain stress integration. HERMANJS@UCMAIL.UC.EDU

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Herr, Andrew Biophysical and structural studies of proteins involved in bacterial biofilm formation, humoral immune responses, andthrombosis. herrab@ucmail.uc.edu

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Hershey, Gurjit focuses on delineating the genetic and environmental factors that promote asthma /allergy phenotypes and dissecting the mechanisms by which they confer risk, and significantlyadvancing the knowledge of the immunomodulatory roles of allergens and other exposures
gurjit.hershey@cchmc.org

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Hildeman, David Molecular biology of antigen-specific T cells, including cell signaling, apoptosis, and development of memory. Noveltherapeutics to eliminate T cells causing autoimmunity and transplant rejection. david.hildeman@cchmc.org

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Ho, Chia-Chi Apply micro fabrication and nanotechnology to construct precisely designed geometrical networks of neuronal cluster and bottom up assembly of tissues chiachi.ho@uc.edu

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Hoebe, Kasper Innate-adaptive connection; mechanisms underlying NK cell and CD8+ T cell development; cytolytic effector function; safer vaccine approaches, T cell-mediated colitis kasper.hoebe@cchmc.org

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Hogan, Simon Focuses on understanding the immune-intestinal epithelial interactions and how alterations in these pathways predispose to the development and maintenance of chronic inflammatory diseases such as food allergy, infection-induced diarrheal diseases, cystic fibrosis (CF) and inflammatory bowel disease (IBD).
simon.hogan@cchmc.org

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Holland, Christy Diagnostic and therapeutic ultrasound and image-guided targeted drug delivery. Christy.Holland@uc.edu

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Holland, Scott Functional MRI of language, hearing and neuroplasticity following brain injury scott.holland@cchmc.org

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Hong, Christian Molecular dynamics of circadian rhythms and its interactions with other molecular mechanisms such as cell cycle. christian.hong@uc.edu

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Huang, Taosheng Molecular basis of genetic syndromes, to apply the discoveries from rare diseases to common conditions, and to develop treatments for genetic diseases taosheng.huang@cchmc.org

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Hui, David Influence of genetic factors such as apoE, LDL receptor family proteins, and pancreatic digestive enzymes, in modulating cardiometabolic diseases, including atherosclerosis, obesity, and diabetes. huidy@ucmail.uc.edu

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Hwa, Vivian Our lab is interested in studying patients with severe growth disorders in order to understand the molecular basis of growth and its perturbations. Vivian.Hwa@cchmc.org

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Janssen, Edith Mechanistic analysis and translational exploitation of the processes in dendritic cells that balance pro- and anti-inflammatory immune responses to self after cell death edith.janssen@cchmc.org

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Jiang, Rulang Mechanisms of craniofacial, kidney, and musculoskeletal organ development rulang.jiang@cchmc.org

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Kalfa, Theodosia Rho-GTPases-associated signaling in erythropoiesis; Rac GTPases and NADPH oxidase in generation of ROS from sickle cells and their role in SCD pathogenesis.

theodosia.kalfa@cchmc.org

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Kalin, Tanya Transcriptional regulation of cancer initiation, progression and metastasis. Tumor microenvironment. Pulmonaryfibrosis. Chemotherapeutic drug development. tatiana.kalin@cchmc.org

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Kalinichenko, Vladimir Transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis; winged helix/forkhead box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival; identify and increase understanding of currently unknown mechanisms that cause human lung malformations and promote lung cancer formation

vladimir.kalinichenko@cchmc.org

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Kopan, Raphael Mechanism of notch signaling, its role in organogenesis, the impact of aging on stem cells and the chromatinregulation by transcription factors at the single cell level.

Raphael.Kopan@cchmc.org

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Kottyan, Leah

The Kottyan lab works to identify the molecular mechanisms mediating the genetic etiology of Systemic lupus erythematous and Eosinophilic Esophagitis.

leah.kottyan@cchmc.org

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Kovall, Rhett Transcription regulation in the Notch signaling pathway; aberrant Notch signaling underlying the pathogenesis of human diseases including congenital defects, cardiovascular disease, and cancer.

rhett.kovall@uc.edu

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Kranias, Litsa Elucidate the role of Ca-handling and Ca-signaling in myocardial function and survival with the aim to provide fundamental mechanistic insights and identify novel therapeutic modalities. litsa.kranias@uc.edu

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Kumar, Ashish We are studying the biology of infant leukemia to identify novel therapeutic approaches. ashish.kumar@cchmc.org

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Lang, Richard Eye Development and Vascular Development richard.lang@cchmc.org

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Le Cras, Tim Pathogenesis and Therapeutic Targeting of Chronic lung diseases, including Asthma, Bronchopulmonary dysplasia,Pulmonary fibrosis, & Pulmonary hypertension Tim.LeCras@cchmc.org

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Lingrel, Jerry Pattern of gene expression during development of several tissue, inculding lung, kidney, heart, T cells, adipocytes and endothelial cells jerry.lingrel@uc.edu

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Lorenz, John Integrative physiology of mice with selectively induced genetic mutations in the gastrointestinal-renal cardiovascularaxis john.lorenz@uc.edu

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Lu, Long (Jason) Unraveling the molecular mechanisms underlying human diseases using computational approaches long.lu@cchmc.org

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Lu, Q. Richard Transcriptional and epigenetic control of glial development and brain tumor formation. Richard.Lu@cchmc.org

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Ma, Jun Molecular investigations of developmental robustness and transcription control majn@ucmail.uc.edu

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Mackenzie, Bryan Iron homeostasis and disorders of iron metabolism. Molecular physiology and structure–function of human iron-transport proteins (DMT1, ferroportin, ZIP14). bryan.mackenzie@uc.edu

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Mast, T. Douglas Medical applications of ultrasound, including real-time image guidance of thermal ablation for cancer treatment, focused ultrasound surgery, and ultrasound-enhanced drug delivery.

doug.mast@uc.edu

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McCormack, Francis Particularly interested in the antimicrobial, antioxidant, and immunomodulatory roles of surfactant proteins A and D in the alveolar space frank.mccormack@uc.edu

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Mersha,Tesfaye

Dr. Mersha’s research interests lie in combining quantitative, ancestry and statistical genomics to unravel genetic and non-genetic contributions to asthma and asthma-related allergic disorders in human populations.

tesfaye.mersha@cchmc.org

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Millay, Douglas We are interested the mechanisms that govern the development and regeneration of skeletal muscle. Our current focus is to understand the molecules and mechanisms that mediate myoblast fusion. Douglas.Millay@cchmc.org

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Molkentin, Jeffery Transcriptional control of cardiac development and the molecular signaling pathways involved in cardiac hypertrophy jeff.molkentin@cchmc.org

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Montrose, Marshall Cellular and sub-cellular physiology of epithelial cells lining the gastrointestinal tract as related to Helicobacter pyloriinfection, peptic ulcer, and colitis. montromh@ucmail.uc.edu

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Morrow, Ardythe Human milk; child health and nutrition ardythe.morrow@cchmc.org

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Muglia, Louis Genetic and developmental mechanisms controlling the timing of birth and risk of preterm birth; molecular genetic analysis of the behavioral and neuroendocrine responses to stress louis.muglia@cchmc.org

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Nakafuku, Masato Molecular control of neural stem cells in development and regeneration of mammalian central nervous system. masato.nakafuku@cchmc.org

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Nakamura, Takahisa Molecular mechanism of obesity-induced metabolic diseases takahisa.nakamura@cchmc.org

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Namekawa, Satoshi Understanding the mechanism and evolution of epigenetic events during mammalian reproduction satoshi.namekawa@cchmc.org

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Norman, Andrew Developing pharmacotherapies for drug abuse using self-administration behavior as a bioassay system to measure the absolute pharmacodynamic and pharmacokinetic potencies of receptor agonists and antagonists andrew.norman@uc.edu

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Obici, Silvana Pathophysiology of obesity and diabetes and effects of exercise; CNS control of energy balance, metabolism andinsulin action. obicis@uc.edu

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Owens, Phillip phillip.owens@uc.edu

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 Ozbudak, Ertugrul
We aim to achieve a systems-level understanding of robust spatiotemporal pattern formation (e.g. rhythmic segmentation of somites) and cell fate determination by integrating quantitative experiments with computational modeling. These efforts aim to provide a mechanistic understanding of congenital diseases.   Ertugrul.Ozbudak@cchmc.org
Pan, Dao Combined translational, bioengineering and basic research on vector-mediated stem call, gene therapy for patientis with lysosomal diseases, especially CNS abnormalities and bone diseases Dao.Pan@cchmc.org

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Perl, Anne-Karina Understanding the molecular and cellular mechanisms that regiulate lung fibroblast function and differentitationduring development, alveolar regeneration, fibrosis and lung transplant biology. anne.perl@cchmc.org

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Pinney, Susan Cancer epidemiology, reproductive epidemiology, screening, environmental biomarkers, exposure metrics. susan.pinney@uc.edu

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Plas, David We study signal transduction and targeted therapeutics in the control of tumor cell metabolism and apoptosis. mTOR,S6K1, and FOXOs are specific areas of investigation. david.plas@uc.edu

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Qi, Xiaoyang Focused on developing novel theragnostic nanovesicles which have the potential to offer a
targeted, potent, broad, and safe therapeutic efficacy and diagnostic application for cancer patient.
xiaoyang.qi@cchmc.org

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Qualls, Joseph
Immunology; innate immunity; macrophage biology; amino acid metabolism; intracellular pathogenesis

joseph.qualls@cchmc.org

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Rance, Mark Application of NMR spectroscopy to macro-molecular structure; The structure/dynamics/function relationship in proteins and protein-nucleic acid complexes rancema@ucmail.uc.edu

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Ratner, Nancy Development of the nervous system; peripheral nerve tumor formation; Genetic mutations in tumor suppressor genes; Ras signal transduction

nancy.ratner@cchmc.org

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Reponen, Tiina Indoor allergens and mold; airborne allergens, bacteria, and fungi; exposure assessment in population-based studies. Tiina.Reponen@uc.edu

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Ridgeway, William Interested in autoimmunity, immunogenetics, T cells, autoimmune (type I) diabetes, autoimmune liver disease(primary biliary cirrhosis), and relapsing polychondritis william.ridgway@uc.edu

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Rothenberg, Marc Mechanisms of Allergic Inflammation.Genomic Analysis, Personalized Medicine, and Translational Research Inquiry of Allergy, with focus on Eosinophilic
Disorders

marc.rothenberg@cchmc.org

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Ryan, Patrick Epidemiology; air pollution; exposure assessment

patrick.ryan@cchmc.org

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Schultz, Jo El Role of opioid peptides and growth factors in cardiovascular function and response to stress and injury; mechanisms and pathology of cardiac function, cardiac growth and ischemia-reperfusion injury; role of growth factors in angiogenesis and ischemia-induced collateralization
schuljo@ucmail.uc.edu

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Shearn, Jason Create better tissue engineered constructs for implantation and understand the mechanical environment for normal, injured and repairing tendons and ligaments jason.shearn@uc.edu

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Singh, Harinder Regulatory molecules that enable a self-renewing pluripotent hematopoietic stem cell to generate various cells of the immune system Harinder.Singh@cchmc.org

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Soleimani, Manoocher Cellular and molecular mechanisms of pH regulation in the kidney. soleimm@ucmail.uc.edu

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Spearman, Paul

Pediatric infectious disease; HIV assembly, HIV biology/pathogenesis, HIV vaccines; vaccines and therapeutics for children (clinical trials)

paul.spearman@cchmc.org

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Starczynowski, Daniel Interested in the molecular, cellular, and genetic basis of hematologic malignancies, with a specific focus on Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML).

daniel.starczynowski@cchmc.org

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Steckl, Andrew Nanoelectronics, biotech materials and devices a.steckl@uc.edu

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Stottmann, Rolf Developmental neurobiology; genetics; animal models of human congenital defects

Rolf.Stottmann@cchmc.org

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Thompson, Thomas Structure-function studies of the TGFbeta family and of apolipoproteins thompstb@ucmail.uc.edu

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Tranter, Michael The ongoing work in the Tranter lab is broadly centered around post-transcriptional gene regulation in the setting of (1) pathological left ventricular hypertrophy and fibrosis, and (2) the mechanisms of cardioprotection against ischemia/reperfusion injury.

trantemc@ucmail.uc.edu

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Trapnell, Bruce Pulmonary alveolar proteinosis; cystic fibrosis; alpha-1 antitrypsin deficiency; other rare lung disorders; Alveolar macrophage function; molecular techniques using gene knockout, transgenic and conditional gene expression mouse models and non-human primates, in vitro and in vivo viral gene transfer, and bone marrow transplantation

bruce.trapnell@cchmc.org

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Tso, Patrick Mechanims and regulation of assembly and secretion of triglyceride-rich lipoproteins; role of hypothalamic dysfunction in the development of obesity tsopp@ucmail.uc.edu

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Ulrich-Lai, Yvonne Identify the neural and hormonal substrates that are responsible for the interactions among diet, obesity and stress. yvonne.ulrich-lai@uc.edu

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Waggoner, Stephen NK cells control disease pathogenesis during infection by killing T cells. Targeting NK-cell immunoregulation may facilitate prevention or treatment of human diseases, including autoimmunity. Stephen.Waggoner@cchmc.org

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Waltz, Susan Molecular analysis of growth factors and receptor tyrosine kinases in tumorigenesis, organ function, and cellulartrauma waltzse@ucmail.uc.edu

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Waxman, Joshua Molecular mechanisms and signaling of organogenesis. Molecular and genetic regulation of cardiovascular
development.
joshua.waxman@cchmc.org

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Way, Sing Sing Our laboratory investigates the pathogenesis and immune response to infection using cellular immunology, recombinant microbial, and transgenic mouse tools with complementary analysis in human tissue. singsing.way@cchmc.org

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Weaver, Timothy Pathogenesis of interstitial lung diseases; protein misfolding and lung disease; epithelial barrier function in the lung and role in asthma pathogenesis tim.weaver@cchmc.org

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Weirauch, Matt

The Weirauch lab uses computational and experimental tools to understand the mechanisms of gene transcriptional regulation and how these mechanisms go awry in disease states.

matthew.weirauch@cchmc.org

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Weiss, Alison Diagnostics for influenza, Bordetella pertussis, E. coli O157:H7; interactions of bacterial toxins and virulance factorswith host cells and immune defenses weissaa@ucmail.uc.edu

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Wells, James Edoderm organogenesis and promoting the differentiation of embryonic stem cells into therapeutic endoderm derivatives james.wells@cchmc.org

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Wells, Susanne Papilloma virus,cervical cancer, head and neck cancer, and breast cancer. susanne.wells@cchmc.org

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White, Peter Bioinformatics, biomedical informatics, genome informatics peter.white@cchmc.org

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Whitsett, Jeffrey Organ morphogenesis, gene regulation, cell differentiation, respiratory disease jeffrey.whitsett@cchmc.org

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Wikenheiser-Brokamp, Kathryn Genetic basis of lung disease with specific interest in Rb/p16 and p53 pathways and identifying key miRNAs
and signaling pathways controlling lung development and tumorigenesis
kathryn.wikenheiser-brokamp@cchmc.org

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Woods, Stephen Mechanisms of obesity and its control. woodssc@ucmail.uc.edu

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Yoshida, Yutaka Understanding molecular mechanisms underlying neural circuit formation in the developing spinal cord usingtechniques including molecular biology, mouse genetics, biochemistry, trans-synaptic vuruses, and electrophysiology yutaka.yoshida@cchmc.org

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Yutzey, Katherine Molecular mechanisms of heart development and disease katherine.yutzey@cchmc.org

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Zavros, Yana Multi-step model for gastric cancer (inflammatory phase, alterations of the epithelial cell cycle, atrophy, intestinal metaplasia, dysplasia and the eventual development of gastric cancer; understanding the Correa model, the interaction between Shh expression, parietal cell function, Pepsin A protease and the development of gastric cancer. yana.zavros@uc.edu

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Zheng, Yi Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions. yi.zheng@cchmc.org

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Zorn, Aaron We elucidate the Gene Regulatory Networks controling embryonic development of foregut stem cells into organsincluding lung, liver and pancreas for regenerative medicine. Aaron.Zorn@cchmc.org

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Faculty members.

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